Art
J-GLOBAL ID：201102256500483762   Reference number：11A0478401

FTY720 (fingolimod) efficacy in an animal model of multiple sclerosis requires astrocyte sphingosine 1-phosphate receptor 1 (S1P1) modulation

多発性硬化症の動物モデルでのFTY720(フィンゴリモド)の効果は星状細胞スフィンゴシン1-燐酸受容体1(S1P1)調節を必要とする
Author (12)：
CHOI Ji Woong

About CHOI Ji Woong

(Scripps Res. Inst., CA)

About Scripps Res. Inst., CA

, 
GARDELL Shannon E.

About GARDELL Shannon E.

(Scripps Res. Inst., CA)

About Scripps Res. Inst., CA

, 
HERR Deron R.

About HERR Deron R.

(Scripps Res. Inst., CA)

About Scripps Res. Inst., CA

, 
RIVERA Richard

About RIVERA Richard

(Scripps Res. Inst., CA)

About Scripps Res. Inst., CA

, 
LEE Chang-Wook

About LEE Chang-Wook

(Scripps Res. Inst., CA)

About Scripps Res. Inst., CA

, 
NOGUCHI Kyoko

About NOGUCHI Kyoko

(Scripps Res. Inst., CA)

About Scripps Res. Inst., CA

, 
TEO Siew Teng

About TEO Siew Teng

(Scripps Res. Inst., CA)

About Scripps Res. Inst., CA

, 
YUNG Yun C.

About YUNG Yun C.

(Scripps Res. Inst., CA)

About Scripps Res. Inst., CA

, 
YUNG Yun C.

About YUNG Yun C.

(Univ. California at San Diego, CA)

About Univ. California at San Diego, CA

, 
LU Melissa

About LU Melissa

(Scripps Res. Inst., CA)

About Scripps Res. Inst., CA

, 
KENNEDY Grace

About KENNEDY Grace

(Scripps Res. Inst., CA)

About Scripps Res. Inst., CA

, 
CHUN Jerold

About CHUN Jerold

(Scripps Res. Inst., CA)

About Scripps Res. Inst., CA


Material：
Proceedings of the National Academy of Sciences of the United States of America  (PNAS)

About Proceedings of the National Academy of Sciences of the United States of America


Volume： 108  Issue： 2  Page： 751-756  Publication year： Jan. 11, 2011 
JST Material Number： D0387A  ISSN： 0027-8424  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)
Thesaurus term：
Thesaurus term/Semi thesaurus term
Keywords indexed to the article.
All keywords is available on JDreamIII(charged).
On J-GLOBAL, this item will be available after more than half a year after the record posted. In addtion, medical articles require to login to MyJ-GLOBAL.
*Multiple Sclerosis

About Multiple Sclerosis

, 
experimental disease

About experimental disease

, 
astrocyte

About astrocyte

, 
*signal transduction receptor

About signal transduction receptor

, 
phospholipid

About phospholipid

, 
*action mechanism

About action mechanism

, 
*Central Nervous System

About Central Nervous System

, 
target

About target

, 
*Sphingosine-1-Phosphate Receptors

About Sphingosine-1-Phosphate Receptors

, 
cell signaling

About cell signaling

, 
Cell Physiological Phenomena

About Cell Physiological Phenomena


Semi thesaurus term：
Thesaurus term/Semi thesaurus term
Keywords indexed to the article.
All keywords is available on JDreamIII(charged).
On J-GLOBAL, this item will be available after more than half a year after the record posted. In addtion, medical articles require to login to MyJ-GLOBAL.
cell physiology

About cell physiology

, 
*action mechanism

About action mechanism

, 
Treatment target

About Treatment target


JST classification (2)：
JST classification
Category name(code) classified by JST.
Basic neurology 
(GN01020W)

About Basic neurology

,  Receptors on cell membrane 
(EF04030C)

About Receptors on cell membrane

Substance index (2)：
Substance index
Chemical Substance indexed to the Article.
Fingolimod

About Fingolimod

, 
Sphingosine-1-phosphate

About Sphingosine-1-phosphate

Terms in the title (10)：
Terms in the title
Keywords automatically extracted from the title.
多発性硬化症

About 多発性硬化症

, 
動物

About 動物

, 
モデル

About モデル

, 
FTY720

About FTY720

, 
フィンゴリモド

About フィンゴリモド

, 
星状細胞

About 星状細胞

, 
スフィンゴシン

About スフィンゴシン

, 
燐酸

About 燐酸

, 
受容体

About 受容体

, 
調節

About 調節


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