Low-molecular-weight compounds having neurotrophic activity in cultured PC12 cells and neurons

MARUOKA Hiroki; MARUOKA Hiroki; SASAYA Harue; SASAYA Harue; SUGIHARA Kensuke; SHIMOKE Koji; IKEUCHI Toshihiko

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J-GLOBAL ID：201102263390319186 Reference number：11A1881703

Low-molecular-weight compounds having neurotrophic activity in cultured PC12 cells and neurons

PC12培養細胞及びニューロンにおける神経栄養活性を持つ低分子量化合物

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Material：
Volume： 150 Issue： 5 Page： 473-475 Publication year： Nov. 2011
JST Material Number： W1920A ISSN： 0021-924X CODEN： JOBIAO Document type： Article
Article type：短報 Country of issue： United Kingdom (GBR) Language： ENGLISH (EN)

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Basic neurology , Cytokines

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Reference (20)：

KAPLAN, D. R. Signal transduction by the neurotrophin receptors. Curr. Opin. Cell Biol. 1997, 9, 213-221
SHIMOKE, K. Protection from ER stress-mediated apoptosis by the neurotrophins. Curr. Topics Biochem. Res. 2009, 11, 19-28
KOSAKA, K. Role of Nrf2 and p62/ZIP in the neurite outgrowth by carnosic acid in PC12h cells. J. Biochem. 2010, 147, 73-81
SATOH, T. Carnosic acid, a catechol-type electrophilic compound, protects neurons both in vitro and in vivo through activation of the Keap1/Nrf2 pathway via S-alkylation of targeted cysteines on Keap1. J. Neurochem. 2008, 104, 1116-1131
LIN, C. W. Neurotrophic and cytoprotective action of luteolin in PC12 cells through ERK-dependent induction of Nrf2-driven HO-1 expression. J. Agric. Food Chem. 2010, 58, 4477-4486

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