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J-GLOBAL ID：201102267803237308   Reference number：11A1680187

Adrenaline受容体の精密構造の解明は抗精神病薬の薬理に何をもたらすか?-鍵(ligand)と鍵穴(受容体pocket)の概念の修正-

Author (3)： MOROOKA YOSHIHIKO ,  HIRAI KENJI (相模中央化研) ,  WATANABE ISANOBU (緑誠会 光の丘病院)
Material： 臨床精神薬理  (Japanese Journal of Clinical Psychopharmacology)
Volume： 14  Issue： 11  Page： 1851-1858  Publication year： Nov. 10, 2011 
JST Material Number： L3883A  ISSN： 1343-3474  Document type： Article
Article type： 解説  Country of issue： Japan (JPN)  Language： JAPANESE (JA)

Thesaurus term： adrenergic receptor ,...
Semi thesaurus term： reverse tolerance phenomenon ,...

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JST classification (1)： Basic research of psychotropic drugs  (GW03100Y)

Reference (18)：

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• 2) Farde, L., Wiesel, F. A., Halldin, C. et al. : Central D₂-dopamine receptor occupancy in schizo-phrenic patients treated with antipsychotic drugs. Arch. Gen. Psychiatry, 45 (1) : 71-76, 1988.
• 3) Farde, L., Nordstrom, A. L., Wiesel, F. A. et al. : Position emission tomographic analysis of cen-tral D₁ and D₂ dopamine receptor occupancy in patients treated with classical neuroreceptics and clozapine. Relation to extrapyramidal side ef-fects. Arch. Gen. Psychiatry, 49 (7) : 538-544, 1992.
• 4) Fritze, I. M., Linden, L., Freigang, J. et al. : The crystal structures of zea mays and arabidopsis 4-hydroxyphenylpyruvate dioxygenase. Plant Physiol., 134 : 1388-1400,2004.
• 5)伊豫雅臣:Aripirazoleの薬理と脳内ドパミンD₂受容体占拠率.臨床精神薬理,9:191-196,2006.

Terms in the title (6)： 受容体 ,  精密 ,  抗精神病薬 ,  鍵 ,  鍵穴 ,  概念