Art

J-GLOBAL ID：201102272572703754   Reference number：11A0648344

Synthesis of 4-unsubstituted dihydropyrimidines. Nucleophilic substitution at position-2 of dihydropyrimidines

4-非置換ジヒドロピリミジン類の合成 ジヒドロピリミジン類の2-位での求核置換

Author (12)： CHO Hidetsura (Graduate School of Sci., Tohoku Univ., 6-3 Aoba, Aramaki, Aoba-ku, Sendai 980-8578, JPN) ,  CHO Hidetsura (Graduate School of Pharmaceutical Sciences, Tohoku Univ., JPN) ,  NISHIMURA Yoshio (Graduate School of Pharmaceutical Sciences, Tohoku Univ., JPN) ,  NISHIMURA Yoshio (Fac. of Pharmacy, Yasuda Women’s Univ., 6-13-1, Yasuhigashi, Asaminami-ku, Hiroshima 731-0153, JPN) ,  YASUI Yoshizumi (WPI Advanced Inst. for Materials Res., Tohoku Univ., JPN) ,  KOBAYASHI Satoshi (Graduate School of Pharmaceutical Sciences, Tohoku Univ., JPN) ,  YOSHIDA Shin-ichiro (Graduate School of Sci., Tohoku Univ., 6-3 Aoba, Aramaki, Aoba-ku, Sendai 980-8578, JPN) ,  YOSHIDA Shin-ichiro (Res. and Analytical Center for Giant Molecules, Tohoku Univ., JPN) ,  KWON Eunsang (Graduate School of Sci., Tohoku Univ., 6-3 Aoba, Aramaki, Aoba-ku, Sendai 980-8578, JPN) ,  KWON Eunsang (Res. and Analytical Center for Giant Molecules, Tohoku Univ., JPN) ,  YAMAGUCHI Masahiko (Graduate School of Pharmaceutical Sciences, Tohoku Univ., JPN) ,  YAMAGUCHI Masahiko (WPI Advanced Inst. for Materials Res., Tohoku Univ., JPN)
Material： Tetrahedron  (Tetrahedron Symposia-in-Print)
Volume： 67  Issue： 14  Page： 2661-2669  Publication year： Apr. 08, 2011 
JST Material Number： E0234A  ISSN： 0040-4020  Document type： Article
Article type： 原著論文  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Thesaurus term： chemical synthesis ,  nitrogen heterocyclic compound ,  *nucleophilic substitution reaction ,  regiospecific reaction ,  alkoxycarbonylation ,  tautomerism ,  X-Ray Diffraction ,  *hydropyrimidine derivatives

JST classification (1)： Pyrimidines  (CF07103W)

Substance index (11)： 2-Thioxo-4-methyl-1,2,3,6-tetrahydropyrimidine-5-carboxylic acid ethyl ester ,  2-(Methylthio)-4-methylpyrimidine-1,5(6H)-dicarboxylic acid 1-tert-butyl 5-ethyl ester ,  2-Anilino-4-methylpyrimidine-1,5(6H)-dicarboxylic acid 1-tert-butyl 5-ethyl ester ,  2-(4-Methoxyanilino)-4-methylpyrimidine-1,5(6H)-dicarboxylic acid 1-tert-butyl 5-ethyl ester ,  2-[4-(Methoxycarbonyl)anilino]-4-methylpyrimidine-1,5(6H)-dicarboxylic acid 1-tert-butyl 5-ethyl ester ,  2-[[3-[(Dimethylamino)methyl]-3,4-dihydro-2H-1-benzopyran-6-yl]amino]-4-methylpyrimidine-1,5(6H)-dicarboxylic acid 1-tert-butyl 5-ethyl ester ,  2-(Hexylamino)-4-methylpyrimidine-1,5(6H)-dicarboxylic acid 1-tert-butyl 5-ethyl ester ,  2-[(Benzyloxy)amino]-4-methylpyrimidine-1,5(6H)-dicarboxylic acid 1-tert-butyl 5-ethyl ester ,  2-(Benzylamino)-4-methylpyrimidine-1,5(6H)-dicarboxylic acid 1-tert-butyl 5-ethyl ester ,  2-Pyrrolizino-4-methylpyrimidine-1,5(6H)-dicarboxylic acid 1-tert-butyl 5-ethyl ester ,  2-Phenyl-3-oxo-7-methyl-2,3,5,8-tetrahydro-1,2,4-triazolo[4,3-a]pyrimidine-6-carboxylic acid ethyl ester

Terms in the title (2)： 非置換 ,  求核置換