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J-GLOBAL ID：201102279931912105   Reference number：11A0527582

Biphasic Tracheal Relaxation Induced by Higenamine and Nantenine From Nandina domestica THUNBERG

ナンテンNandina domestica THUNBERGからのヒゲナミン及びナンテニンにより誘導される二相性気管弛緩

Author (6)： UEKI Takuro (Lab. of Pharmacology, Fac. of Pharmacy and Res. Inst. of Pharmaceutical Sciences, Musashino Univ., JPN) ,  UEKI Takuro (TOKIWA Pharmaceutical Co., Ltd., JPN) ,  AKAISHI Tatsuhiro (Lab. of Pharmacology, Fac. of Pharmacy and Res. Inst. of Pharmaceutical Sciences, Musashino Univ., JPN) ,  OKUMURA Hidenobu (TOKIWA Pharmaceutical Co., Ltd., JPN) ,  MORIOKA Tsuneo (TOKIWA Pharmaceutical Co., Ltd., JPN) ,  ABE Kazuho (Lab. of Pharmacology, Fac. of Pharmacy and Res. Inst. of Pharmaceutical Sciences, Musashino Univ., JPN)
Material： Journal of Pharmacological Sciences  (J Pharmacol Sci)
Volume： 115  Issue： 2  Page： 254-257 (J-STAGE)  Publication year： 2011 
JST Material Number： G0813A  ISSN： 1347-8613  Document type： Article
Article type： 短報  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *Berberidaceae ,...
Semi thesaurus term： Nandina domestica ,...

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JST classification (3)： Aromatic monocyclic phenols and polyphenols  (CF05090V) ,  Plant biochemistry  (EH01050J) ,  Basic research of drugs acting on respiration and respiratory system  (GW08010J)

Substance index (3)： Nantenine ,  Higenamine ,  Propranolol

Reference (15)：

• 1 Takase T, Ohashi H. [Chemische u. pharmakologische Studien über ein in den Fruchten der Nandina domestica enthaltenes neues Alkaloid, Nantenin]. Yakugaku Zasshi. 1926;535:742–748. (text in Japanese with German abstract)
• 2 Tsukiyama M, Akaishi T, Ueki T, Okumura H, Abe K. The extract from Nandina domestica Thunberg inhibits histamine- and serotonin-induced contraction in isolated guinea pig trachea. Biol Pharm Bull. 2007;30:2063–2068.
• 3 Tsukiyama M, Ueki T, Yasuda Y, Kikuchi H, Akaishi T, Okumura H, et al. β₂-Adrenoceptor-mediated tracheal relaxation induced by higenamine from Nandina domestica Thunberg. Planta Med. 2009;75:1393–1399.
• 4 Kosuge T, Yokota M, Nagasawa M. [Studies on cardiac principle of aconite roots. Isolation and structure determination of higenamine]. Yakugaku Zasshi. 1978;98:1370–1375. (text in Japanese with English abstract)
• 5 Park CW, Chang KC, Lim JK. Effects of higenamine on isolated heart adrenoceptor of rabbit. Arch Int Pharmacodyn Ther. 1984;267:279–288.

Terms in the title (7)： ナンテン ,  ヒゲナミン ,  ナンテニン ,  誘導 ,  二相性 ,  気管 ,  弛緩