Art

J-GLOBAL ID：201102295089942179   Reference number：11A1994106

Dorsomorphin stimulates neurite outgrowth in PC12 cells via activation of a protein kinase A-dependent MEK-ERK1/2 signaling pathway

ドルソモルフィンは蛋白質キナーゼAに依存するMEK-ERK1/2シグナル伝達経路の活性化を通してPC12細胞における神経突起の成長を刺激する

Author (11)： KUDO Tada-aki (Tohoku Univ. Graduate School of Dentistry, Sendai, JPN) ,  KANETAKA Hiroyasu (Tohoku Univ. Graduate School of Dentistry, Sendai, JPN) ,  KANETAKA Hiroyasu (Tohoku Univ. Graduate School of Biomedical Engineering, Sendai, JPN) ,  MIZUNO Kazutoshi (Tohoku Univ. Graduate School of Dentistry, Sendai, JPN) ,  RYU Yasuhiro (Tohoku Univ. Graduate School of Dentistry, Sendai, JPN) ,  MIYAMOTO Yoshiyuki (Tohoku Univ. Graduate School of Dentistry, Sendai, JPN) ,  NUNOME Shoko (Tohoku Univ. Graduate School of Dentistry, Sendai, JPN) ,  ZHANG Ye (Tohoku Univ. Graduate School of Biomedical Engineering, Sendai, JPN) ,  KANO Mitsuhiro (Tohoku Univ. Graduate School of Dentistry, Sendai, JPN) ,  SHIMIZU Yoshinaka (Tohoku Univ. Graduate School of Dentistry, Sendai, JPN) ,  HAYASHI Haruhide (Tohoku Univ. Graduate School of Dentistry, Sendai, JPN)
Material： Genes to Cells  (Genes Cells)
Volume： 16  Issue： 11  Page： 1121-1132  Publication year： Nov. 2011 
JST Material Number： W0935A  ISSN： 1356-9597  CODEN： GECEFL  Document type： Article
Article type： 原著論文  Country of issue： Australia (AUS)  Language： ENGLISH (EN)

Thesaurus term： *ERK ,...
Semi thesaurus term： MEK ,...

Register(free) or Log In to access     To see more with JDream III (charged).   {{ this.onShowAbsJLink("http://jdream3.com/lp/jglobal/index.html?docNo=11A1994106&from=J-GLOBAL&jstjournalNo=W0935A") }}

JST classification (3)： Enzyme physiology  (EJ02020P) ,  Cell physiology in general  (EF02010S) ,  Physicochemical pharmacy in general  (GV01010J)

Reference (51)：

• Ahn, N.G. & Tolwinski, N.S. (1999) U0126: an inhibitor of MKK/ERK signal transduction in mammalian cells. Promega Notes 71, 4-8.
• Boergermann, J.H., Kopf, J., Yu, P.B. & Knaus, P. (2010) Dorsomorphin and LDN-193189 inhibit BMP-mediated Smad, p38 and Akt signalling in C2C12 cells. Int. J. Biochem. Cell Biol. 42, 1802-1807.
• Burry, R.W. (2001) p21(ras) stimulates pathways in addition to ERK, p38, and Akt to induce elongation of neurites in PC12 cells. J. Neurosci. Res. 63, 45-53.
• Charles, M.P., Adamski, D., Kholler, B., Pelletier, L., Berger, F. & Wion, D. (2003) Induction of neurite outgrowth in PC12 cells by the bacterial nucleoside N6-methyldeoxyadenosine is mediated through adenosine A2a receptors and via cAMP and MAPK signaling pathways. Biochem. Biophys. Res. Commun. 304, 795-800.
• Cuny, G.D., Yu, P.B., Laha, J.K., Xing, X., Liu, J.F., Lai, C.S., Deng, D.Y., Sachidanandan, C., Bloch, K.D. & Peterson, R.T. (2008) Structure-activity relationship study of bone morphogenetic protein (BMP) signaling inhibitors. Bioorg. Med. Chem. Lett. 18, 4388-4392.

Terms in the title (10)： ドルソモルフィン ,  蛋白質キナーゼA ,  MEK ,  ERK1 ,  シグナル伝達経路 ,  活性化 ,  PC12細胞 ,  神経突起 ,  成長 ,  刺激