Art

J-GLOBAL ID：201102295157680935   Reference number：11A0838088

Inhibition of Untransformed Prostaglandin H₂ Production and Stretch-Induced Contraction of Rabbit Pulmonary Arteries by Indoxam, a Selective Secretory Phospholipase A₂ Inhibitor

選択的分泌型ホスホリパーゼA₂阻害剤,インドキサムによる非形質転換プロスタグランジンH₂産生とウサギ肺動脈の伸展誘導収縮の阻害

Author (9)： TANABE Yoshiyuki (Dep. of Molecular and Cellular Pharmacology, School of Pharmaceutical Sciences, Iwate Medical Univ., JPN) ,  TANABE Yoshiyuki (Dep. of Cellular and Molecular Pharmacology, Graduate School of Pharmaceutical Sciences, Univ. of Shizuoka, JPN) ,  SAITO Maki (Dep. of Molecular and Cellular Pharmacology, School of Pharmaceutical Sciences, Iwate Medical Univ., JPN) ,  MORIKAWA Yuki (Dep. of Cellular and Molecular Pharmacology, Graduate School of Pharmaceutical Sciences, Univ. of Shizuoka, JPN) ,  KAMATAKI Akihisa (Dep. of Pathology, School of Medicine, Iwate Medical Univ., JPN) ,  SAWAI Takashi (Dep. of Pathology, School of Medicine, Iwate Medical Univ., JPN) ,  HIROSE Masamichi (Dep. of Molecular and Cellular Pharmacology, School of Pharmaceutical Sciences, Iwate Medical Univ., JPN) ,  NAKAYAMA Koichi (Dep. of Molecular and Cellular Pharmacology, School of Pharmaceutical Sciences, Iwate Medical Univ., JPN) ,  NAKAYAMA Koichi (Dep. of Cellular and Molecular Pharmacology, Graduate School of Pharmaceutical Sciences, Univ. of Shizuoka, JPN)
Material： Journal of Pharmacological Sciences  (J Pharmacol Sci)
Volume： 115  Issue： 4  Page： 525-531 (J-STAGE)  Publication year： 2011 
JST Material Number： G0813A  ISSN： 1347-8613  Document type： Article
Article type： 短報  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *prostaglandin ,...
Semi thesaurus term： hare ,...

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JST classification (3)： Basic research of enzyme preparations and enzyme inhibitor preparations  (GW21010W) ,  Enzyme in general  (EB09010D) ,  Other hormones of verterbrates  (EB08070K)

Substance index (4)： NS-398 ,  Indoxam ,  Thromboxane A2 ,  Prostaglandin H2

Reference (15)：

• FELETOU, M. Vasoconstrictor prostanoids. Pflugers Arch. 2010, 459, 941-950
• SAITO, M. Endothelium-derived prostaglandin H_2 evokes the stretch-induced contraction of rabbit pulmonary artery. Eur J Pharmacol. 2003, 467, 151-161
• MAILE, LA. Modulation of integrin antagonist signaling by ligand binding of the heparin-binding domain of vitronectin to the α_vβ_3 integrin. J Cell Biochem. 2008, 105, 437-446
• BHATTACHARYA, S. Dual signaling by the α_vβ_3-integrin activates cytosolic PLA_2 in bovine pulmonary artery endothelial cells. Am J Physiol Lung Cell Mol Physiol. 2001, 280, L1049-L1056
• UOZUMI, N. Role of cytosolic phospholipase A_2 in allergic response and parturition. Nature. 1997, 390, 618-622

Terms in the title (11)： 分泌型ホスホリパーゼA2 ,  阻害剤 ,  インドキサム ,  形質転換 ,  プロスタグランジンH2 ,  ウサギ ,  肺動脈 ,  伸展 ,  誘導 ,  収縮 ,  阻害