Art

J-GLOBAL ID：201102295513428600   Reference number：11A1265950

Synthesis and Anti-human Immunodeficiency Virus Activity of the Skeleton Isomers of 3′,4′-Di-(O)-(-)-camphanoyl-(+)-khellactone

3′,4′-ジ-(O)-(-)-カンファノイル-(+)-ケールラクトンの骨格異性体の合成および抗ヒト免疫不全ウイルスの活性

Author (10)： NISHIOKA Hiromi (Div. of Pharmaceutical Sciences, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama Univ.) ,  UESUGI Koji (Div. of Pharmaceutical Sciences, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama Univ.) ,  UEDA Norihiro (Div. of Pharmaceutical Sciences, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama Univ.) ,  KONDO Yuka (Div. of Pharmaceutical Sciences, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama Univ.) ,  TSUJI Megumi (Div. of Pharmaceutical Sciences, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama Univ.) ,  ABE Hitoshi (Fac. of Engineering, Toyama Univ.) ,  HARAYAMA Takashi (Div. of Pharmaceutical Sciences, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama Univ.) ,  HAMASAKI Takayuki (Div. of Antiviral Chemotherapy, Center for Chronic Viral Diseases, Graduate School of Medical and Dental Sciences ...) ,  BABA Masanori (Div. of Antiviral Chemotherapy, Center for Chronic Viral Diseases, Graduate School of Medical and Dental Sciences ...) ,  TAKEUCHI Yasuo (Div. of Pharmaceutical Sciences, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama Univ.)
Material： Chemical and Pharmaceutical Bulletin  (Chemical & Pharmaceutical Bulletin)
Volume： 59  Issue： 8  Page： 1075-1076 (J-STAGE)  Publication year： 2011 
JST Material Number： G0504A  ISSN： 0009-2363  CODEN： CPBTAL  Document type： Article
Article type： 短報  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *quantitative structure-activity relationship ,...
Semi thesaurus term： *dihydroxylation ,...

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JST classification (2)： Condensed derivatives of pyrane  (CF07093I) ,  Basic research of antiviral drugs  (GW17040O)

Substance index (18)： (1R,2R)-1,2-Dihydroxy-3,3-dimethyl-1,2-dihydro-3H,8H-benzo[1,2-b:4,3-b′]dipyran-8-one ,  (1R,2R)-8-Oxo-3,3-dimethyl-1,2-dihydro-3H,8H-benzo[1,2-b:4,3-b′]dipyran-1,2-diol 1-[(R)-α-methoxy-α-(trifluoromethyl)phenylacetate] ,  (3R,4R)-2,2-Dimethyl-3,4-dihydroxy-3,4-dihydro-2H,8H-benzo[1,2-b:3,4-b′]dipyran-8-one ,  (3R,4R)-2,2-Dimethyl-3,4-dihydroxy-3,4-dihydro-2H,9H-benzo[2,1-b:3,4-b′]dipyran-9-one ,  (3R,4R)-8-Oxo-2,2-dimethyl-3,4-dihydro-2H,8H-benzo[1,2-b:3,4-b′]dipyran-3,4-diol 3-[(R)-α-methoxy-α-(trifluoromethyl)phenylacetate] ,  (3R,4R)-9-Oxo-2,2-dimethyl-3,4-dihydro-2H,9H-benzo[2,1-b:3,4-b′]dipyran-3,4-diol 4-[(R)-α-methoxy-α-(trifluoromethyl)phenylacetate] ,  (R)-MTPA ,  3′,4′-Di-O-(S)-camphanoyl-(+)-cis-khellactone ,  5-Hydroxycoumarin ,  6-Hydroxycoumarin ,  8-Hydroxycoumarin ,  9,9′′-(2,5-Diphenylpyrimidine-4,6-diyl)bisoxybis[(8R,9R)-10,11-dihydrocinchonan] ,  9,9′′-(2,5-Diphenylpyrimidine-4,6-diyl)bisoxybis[(8S,9R)-10,11-dihydrocinchonan] ,  Bis[(1S,4R)-3-oxo-4,7,7-trimethyl-2-oxabicyclo[2.2.1]heptane-1-carboxylic acid][(1R,2R)-3,3-dimethyl-5-oxo-2,3-dihydro-1H,5H-pyrano[2,3-c][1]benzopyran]-1,2-diyl ester ,  Bis[(1S,4R)-3-oxo-4,7,7-trimethyl-2-oxabicyclo[2.2.1]heptane-1-carboxylic acid][(1R,2R)-8-oxo-3,3-dimethyl-1,2-dihydro-3H,8H-benzo[1,2-b:4,3-b′]dipyran]-1,2-diyl ester ,  Bis[(1S,4R)-3-oxo-4,7,7-trimethyl-2-oxabicyclo[2.2.1]heptane-1-carboxylic acid][(3R,4R)-2,2-dimethyl-5-oxo-3,4-dihydro-2H,5H-pyrano[3,2-c][1]benzopyran]-3,4-diyl ester ,  Bis[(1S,4R)-3-oxo-4,7,7-trimethyl-2-oxabicyclo[2.2.1]heptane-1-carboxylic acid][(3R,4R)-8-oxo-2,2-dimethyl-3,4-dihydro-2H,8H-benzo[1,2-b:3,4-b′]dipyran]-3,4-diyl ester ,  Bis[(1S,4R)-3-oxo-4,7,7-trimethyl-2-oxabicyclo[2.2.1]heptane-1-carboxylic acid][(3R,4R)-9-oxo-2,2-dimethyl-3,4-dihydro-2H,9H-benzo[2,1-b:3,4-b′]dipyran]-3,4-diyl ester

Reference (9)：

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Terms in the title (6)： ケール ,  ラクトン ,  骨格 ,  異性体 ,  ヒト免疫不全ウイルス ,  活性