Art

J-GLOBAL ID：201102298973861890   Reference number：11A0109267

CXCR4 nanobodies (VHH-based single variable domains) potently inhibit chemotaxis and HIV-1 replication and mobilize stem cells

CXCR4ナノボディー(VHHに基づく単一可変領域)は走化とHIV-1複製を阻害し,幹細胞を移動させる可能性がある

Author (17)： JAEHNICHEN Sven (VU Univ. Amsterdam, Amsterdam, NLD) ,  BLANCHETOT Christophe (Utrecht Univ., Utrecht, NLD) ,  MAUSSANG David (VU Univ. Amsterdam, Amsterdam, NLD) ,  GONZALEZ-PAJUELO Maria (Ablynx, Ghent, BEL) ,  CHOW Ken Y. (VU Univ. Amsterdam, Amsterdam, NLD) ,  BOSCH Leontien (VU Univ. Amsterdam, Amsterdam, NLD) ,  DE VRIEZE Sindi (Ablynx, Ghent, BEL) ,  SERRUYS Benedikte (Ablynx, Ghent, BEL) ,  ULRICHTS Hans (Ablynx, Ghent, BEL) ,  VANDEVELDE Wesly (Ablynx, Ghent, BEL) ,  SAUNDERS Michael (Ablynx, Ghent, BEL) ,  DE HAARD Hans J. (Ablynx, Ghent, BEL) ,  SCHOLS Dominique (Katholieke Universiteit Leuven, Leuven, BEL) ,  LEURS Rob (VU Univ. Amsterdam, Amsterdam, NLD) ,  VANLANDSCHOOT Peter (Ablynx, Ghent, BEL) ,  VERRIPS Theo (Utrecht Univ., Utrecht, NLD) ,  SMIT Martine J. (VU Univ. Amsterdam, Amsterdam, NLD)
Material： Proceedings of the National Academy of Sciences of the United States of America  (PNAS)
Volume： 107  Issue： 47  Page： 20565-20570  Publication year： Nov. 23, 2010 
JST Material Number： D0387A  ISSN： 0027-8424  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Thesaurus term： *Chemokine Receptors ,  chemotaxis ,  *viral replication ,  *stem cell ,  *cell migration ,  Leukapheresis ,  binding site ,  cell-mediated immunity ,  genetic technique ,  antiviral action ,  nanostructure ,  chemokine ,  Proteins ,  HIV1 ,  *HIV1 replication ,  V region ,  *cell signaling ,  Epitope Mapping ,  *Cell Physiological Phenomena ,  immunoassay ,  *Receptors, CXCR4 ,  phage display method ,  Chemokine CXCL12 ,  microorganism ,  animal virus ,  bioassay
Semi thesaurus term： *cell physiology ,  immunoassay ,  *CXCR4 ,  phage display ,  CXCL12

JST classification (2)： Cell physiology in general  (EF02010S) ,  Infectious diseases,parasitics diseases in general.  (GD01010H)

Terms in the title (6)： CXCR4 ,  可変領域 ,  複製 ,  阻害 ,  幹細胞 ,  可能性