Sasaki Kazunori

ササキカズノリ | Sasaki Kazunori

Affiliation and department：
Homepage URL (1)： https://ycu-molecularbiology.jp

Research field (6)： Medical biochemistry , Cell biology , Molecular biology , Anatomy , General surgery, pediatric surgery , Urology

Research keywords (28)： cell polarity , 細胞接着 , kinase , aPKC , PAR-3 , タイトジャンクション , stem cell , progenitor , シグナル伝達 , G protein , Guanine nucleotide exchange factor , GEF , Girdin , heterotrimeric G protein , Galphai , 低分子量Gタンパク質 , Rap1 , Shank2 , 遺伝子発現 , 転写 , mammary gland , breast cancer , transcripion factor , Transplantation , cell growth , cell differentiation , organoid , sphere

Papers (27)：

Matsuoka I, Kasai T, Onaga C, Ozaki A, Motomura H, Maemura Y, Tada Y, Mori H, Hara Y, Xiong Y, et al. Co-expression of SLC20A1 and ALDH1A3 is associated with poor prognosis, and SLC20A1 is required for the survival of ALDH1-positive pancreatic cancer stem cells. Oncology Letters. 2024. in press
Ozaki A, Matsuda A, Maemura Y, Tada Y, Kasai T, Nagashima Y, Onaga C, Hara Y, Kitabatake K, Tsukimoto M, et al. Luminal B breast cancer coexpressing p62 and ALDH1A3 is less susceptible to radiotherapy. Anticancer Research. 2024. 44. 1. 37-47
Takahiro Kasai, Shoma Tamori, Yuta Takasaki, Izumi Matsuoka, Ayaka Ozaki, Chika Matsuda, Yohsuke Harada, Kazunori Sasaki, Shigeo Ohno, Kazunori Akimoto. High expression of PKCλ and ALDH1A3 indicates a poor prognosis, and PKCλ is required for the asymmetric cell division of ALDH1A3-positive cancer stem cells in PDAC. Biochemical and biophysical research communications. 2023. 669. 85-94
Okamoto T, Onaga C, Matsuoka I, Ozaki A, Matsuda C, Kasai T, Xiong Y, Harada Y, Sato T, Nakano Y, et al. High SLC20A1 Expression Indicates Poor Prognosis in Prostate Cancer. Cancer Diagn Progn. 2023. 3. 4. 439-448
Xiong Y, Motomura H, Tamori S, Ozaki A, Onaga C, Hara Y, Sato K, Tahata K, Harada Y, Sasaki K, et al. High Expression of CD58 and ALDH1A3 Predicts a Poor Prognosis in Basal-like Breast Cancer. Anticancer Research. 2022. 42. 11. 5223-5232

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MISC (7)：

Hitomi Shiina, Ayaka Ozaki, Shoma Tamori, Yuka Nozaki, Ryoko Takasawa, Kazunori Sasaki, Hitoshi Isiguro, Yohei Miyagi, Yoji Nagashima, Sei-ichi Tanuma, et al. Correlation between Glyoxalase 1 and PKC lambda is predictive of poor clinical outcomes in late-stage breast cancer. CANCER SCIENCE. 2021. 112. 825-825
本村瞳, 尾崎綾栞, 多森翔馬, 翁長朝太郎, 野崎優香, 和氣由布子, 高澤涼子, 吉澤一巳, 真野泰成, 佐藤嗣道, et al. Correlation between Glyoxalase 1 and Protein kinase C λis predictive of poor clinical outcomes in late-stage breast cancer. 日本薬学会年会要旨集(Web). 2021. 141st
本村瞳, 尾崎綾栞, 多森翔馬, 野崎優香, 高澤涼子, 佐々木和教, 石黒斉, 宮城洋平, 長嶋洋治, 田沼靖一, et al. Correlation between GLO1 and PKCλ contributes to prediction for poor clinical outcome at late stage of breast cancer. 日本癌学会学術総会抄録集(Web). 2019. 78th
秋本和憲, 長嶋洋治, 石黒斉, 鄭允文, 佐々木和教, 小島康幸, 谷口英樹, 大野茂男, 野田哲生. 細胞極性制御因子aPKCλによる乳腺上皮前駆細胞の増殖制御とその破綻(aPKCλ, regulates mammary luminal progenitor cell propagation and it's disruption in a subpopulation of breast cancer). 日本癌学会総会記事. 2011. 70回. 105-105
秋本和憲, 鄭允文, 長嶋洋治, 石黒斉, 佐々木和教, 金民大, 李斌, 角和卓, 谷口英樹, 野田哲生, et al. 上皮細胞の機能とその破綻がもたらす病態のメカニズム細胞極性制御因子aPKCλによる上皮前駆細胞の増殖制御とその破綻. 日本生化学会大会・日本分子生物学会年会合同大会講演要旨集. 2010. 83回・33回. 4W6-6

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Books (1)：

翻訳後修飾のプロテオミクス
講談社 2011

Lectures and oral presentations (56)：

Regulation of epithelial cell polarity by the PAR-aPKC complex and G protein signaling
(2024)
乳がんサブタイプにおけるaPKC遺伝子発現と放射線および薬物治療との関連性の解析
(日本薬学会第144年会 2024)
Identification of prognostic genes related to nuclear localized aPKCλ/ι in cervical squamous cell carcinoma
(The 10th International Postgraduate Conference on Pharmaceutical Sciences (iPoPS2024) 2024)
Analysis of the acquisition mechanism of cancerous heterogeneity generating by asymmetric cell division of cancer stem cells
(The 10th International Postgraduate Conference on Pharmaceutical Sciences (iPoPS2024) 2024)
Screening of natural compounds regulating in vitro tumor-sphere formation of ALDH1 positive cancer stem cells
(The 10th International Postgraduate Conference on Pharmaceutical Sciences (iPoPS2024) 2024)

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Awards (1)：

2023/06 - (順天堂大学大学院医学研究科環境医学研究所) 第20回環境医学研究所プロジェクト研究報告会最優秀ポスター賞

Association Membership(s) (2)：

THE JAPANESE CANCER ASSOCIATION , THE MOLECULAR BIOLOGY SOCIETY OF JAPAN

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