Kuboyama Tomoharu

クボヤマトモハル | Kuboyama Tomoharu

Affiliation and department：
Job title：准教授
Homepage URL (1)： https://nrid.nii.ac.jp/ja/nrid/1000010415151/

Research field (3)： Pharmacology , Pharmaceuticals - health and biochemistry , Neuroscience - general

Research keywords (9)： anxiety , Growth cone , Spinal cord injury , Alzheimer's disease , 軸索再生 , Pharmacognosy , Epigenetics , Comprehensive Brain Science Network , コンドロイチン硫酸プロテオグリカン

Research theme for competitive and other funds (14)：

2022 - 2025 Recovery from refractory anxiety by reconstruction of neuronal networks
2021 - 2024 Development of high value-added Rhubarb effective for neurological disorders
2020 - 2022 神経回路網再構築を介した根本的不安障害治療法の確立
2019 - 2022 M2マイクログリアによる軸索伸長作用を介した新規脊髄損傷治療法の開発
2018 - 2021 Development of therapeutic strategy for Alzheimer's disease via M2 microglia

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Papers (42)：

Tomoharu Kuboyama, Kenichiro Hotta, Mai Asanuma, Yue-Wei Ge, Kazufumi Toume, Takuma Yamazaki, Katsuko Komatsu. Quality assessment of Rheum species cultivated in Japan by focusing on M2 polarization of microglia. Journal of natural medicines. 2023. 77. 4. 699-711
Kakeru Chino, Naotaka Izuo, Hiroshi Noike, Kyosuke Uno, Tomoharu Kuboyama, Chihiro Tohda, Shin-Ichi Muramatsu, Atsumi Nitta. Shati/Nat8l Overexpression Improves Cognitive Decline by Upregulating Neuronal Trophic Factor in Alzheimer's Disease Model Mice. Neurochemical research. 2022. 47. 9. 2805-2814
Farid Mai M., 長瀬綸沙, 楊煕蒙, 野本かおり, 久保山友晴, 稲田祐奈, 東田千尋. Trigonella foenum-graecum種子エキスのアルツハイマー病モデルマウスへの作用と活性成分の脳移行性(Effects of Trigonella foenum-graecum seeds extract on Alzheimer's disease transgenic model mouse and its potential active compound transferred to the brain). 日本食品化学学会誌. 2021. 28. 2. 63-70
Tomoharu Kuboyama, Seiya Kominato, Misaki Nagumo, Chihiro Tohda. Recovery from spinal cord injury via M2 microglial polarization induced by Polygalae Radix. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2021. 82. 153452-153452
Mai M Farid, Ximeng Yang, Tomoharu Kuboyama, Chihiro Tohda. Trigonelline recovers memory function in Alzheimer's disease model mice: evidence of brain penetration and target molecule. Scientific reports. 2020. 10. 1. 16424-16424

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MISC (70)：

久保山友晴, 荒毛優太, 塘健太, 南雲美咲, 小湊誠也, 東田千尋. 遠志成分sibiricose A5の抗アルツハイマー病作用とその作用機序の解明. 日本生薬学会年会講演要旨集. 2023. 69回. 123-123
久保山友晴, 堀田健一郎, 浅沼舞, 當銘一文, 山嵜琢磨, 小松かつ子. 長野県栽培Rheum属植物由来根のマイクログリアM2化に着目した品質評価. 和漢医薬学会学術大会要旨集. 2023. 40回. 77-77
久保山友晴. 神経回路網再構築を介した根本的不安障害治療法の確立. 上原記念生命科学財団研究報告集. 2022. 36. 1-5
久保山友晴, 堀田健一郎, 浅沼舞, 當銘一文, 山嵜琢磨, 小松かつ子. 長野県栽培Rheum属植物由来根茎のマイクログリアM2化に着目した品質評価. 日本生薬学会年会講演要旨集. 2022. 68回. 217-217
久保山友晴, 堀田健一郎, 浅沼舞, 當銘一文, 山嵜琢磨, 小松かつ子. マイクログリアM2化活性に着目した長野県産大黄の品質評価. 日本薬学会年会要旨集. 2022. 142年会. 27PO1-03

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Patents (4)：

Education (3)：

2002 - 2005 Toyama Medical and Pharmaceutical University
2000 - 2002 Toyama Medical and Pharmaceutical University
1996 - 2000 Toyama Medical & Pharmaceutical University

Professional career (1)：

Ph.D. (Pharmacy)

Work history (4)：

2020/04 - 現在 Daiichi University of Pharmacy Department of Kampo Pharmacy, Division of Pharmaceutical Sciences Associate Professor
2010/10 - 2020/03 Institute of Natural Medicine, University of Toyama Assistant Professor
2015/03 - 2016/02 Icahn School of Medicine at Mount Sinai Visiting Scholar
2005/04 - 2010/09 RIKEN Brain Science Institute Research scientist

Committee career (2)：

2023/08 - 現在和漢医薬学会代議員
2023/04 - 現在日本生薬学会 JONM編集委員

Awards (4)：

2022/08 - 和漢医薬学会次世代を担う若手研究者の会振興賞
2019/08 - 和漢医薬学会学術貢献賞
2018/11 - 日本薬学会北陸支部支部学術奨励賞
2003/12 - The Sixth JSPS-NRCT Joint Seminar, Excellent Poster Presentation Awards

Association Membership(s) (7)：

The Japanese Society of Pharmacognosy , MEDICAL AND PHARMACEUTICAL SOCIETY FOR WAKAN-YAKU , THE PHARMACEUTICAL SOCIETY OF JAPAN , Society for Neuroscience , THE JAPAN NEUROSCIENCE SOCIETY , THE JAPANESE SOCIETY FOR NEUROCHEMISTRY , THE JAPANESE PHARMACOLOGICAL SOCIETY

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