2017 - 2020 Exploration of Parkinson disease-specific pathological background
2016 - 2020 Analysis of molecular mechanism of synaptic vesicle dynamics which regulated by Parkinson's disease causative genes and identification of therapeutic target of Parkinson's disease related genes.
2016 - 2018 Drug screening to improve mitochondrial functions
2014 - 2018 Elucidation of the mechanism of mitochondrial maintenance by Parkinson's disease gene products
2014 - 2018 A study on the common pathogenesis of Parkinson's disease as a mitochondrial disease
2016 - 2018 パーキンソン病原因遺伝子変異によるシナプス小胞動態異常と治療標的遺伝子探索
2014 - 2017 Establishment of mitophagy imaging method
2017 - Exploration of Parkinson disease-specific pathological background
2012 - 2012 in vivo live imaging for sex pheromone information presentation neural mechanism in Drosophila olfaction
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Papers (32):
Jun-Yi Liu, Tsuyoshi Inoshita, Kahori Shiba-Fukushima, Shigeharu Yoshida, Kosuke Ogata, Yasushi Ishihama, Yuzuru Imai, Nobutaka Hattori. Ubiquitination at the lysine 27 residue of the parkin ubiquitin-like domain is suggestive of a new mechanism of parkin activation. Human molecular genetics. 2022. 31. 15. 2623-2638
Shun Kato, Kohei Arasaki, Natsuki Tokutomi, Yuzuru Imai, Tsuyoshi Inoshita, Nobutaka Hattori, Taeko Sasaki, Miyuki Sato, Yuichi Wakana, Hiroki Inoue, et al. Syntaxin 17, an ancient SNARE paralog, plays different and conserved roles in different organisms. Journal of cell science. 2021. 134. 22
Tsuyoshi Inoshita, Yuzuru Imai. Cytosolic and Mitochondrial Ca2+ Imaging in Drosophila Dopaminergic Neurons. Methods in molecular biology (Clifton, N.J.). 2021. 2322. 207-214
Tsuyoshi Inoshita, Daisaku Takemoto, Yuzuru Imai. Analysis of Dopaminergic Functions in Drosophila. Methods in molecular biology (Clifton, N.J.). 2021. 2322. 185-193
Masayoshi Kano, Masashi Takanashi, Genko Oyama, Asako Yoritaka, Taku Hatano, Kahori Shiba-Fukushima, Makiko Nagai, Kazutoshi Nishiyama, Kazuko Hasegawa, Tsuyoshi Inoshita, et al. Reduced astrocytic reactivity in human brains and midbrain organoids with PRKN mutations. npj Parkinson's Disease. 2020. 6. 1