Research theme for competitive and other funds (6)：
2021 - 2024 電位依存性イオンチャネルの機能構造と構造間遷移機構の解析による動作機構解明
2021 - 2024 B型肝炎ウイルスの肝細胞侵入・増殖機構の構造基盤と立体構造に基づく創薬
2018 - 2021 B型肝炎ウイルスの肝細胞侵入および増殖機構の構造生物学的解析
2017 - 2020 Functional regulation of voltage-gated ion channels targeting the voltage sensor
2016 - 2018 Structural basis for hepatitis B virus infection
2014 - 2016 NMR analyses of the structural equilibrium in tyrosine kinases
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Papers (30)：
Shimizu Y, Yonezawa T, Bao Y, Sakamoto J, Yokogawa M, Furuya T, Osawa M, Ikeda K. Applying deep learning to iterative screening of medium-sized molecules for protein-protein interaction-targeted drug discovery. Chemical Communications. 2023. 59. 44. 6722-6725
Miura M, Sakaue F, Matsuno H, Morita K, Yoshida A, Hara R.I, Nishimura R, Nishida Y, Yokogawa M, Osawa M, et al. TDP-43 N-terminal domain dimerisation or spatial separation by RNA binding decreases its propensity to aggregate. FEBS Letters. 2023. 597. 12. 1667-1676
Sagae T, Yokogawa M, Sawazaki R, Ishii Y, Hosoda N, Hoshino SI, Imai S, Shimada I, Osawa M. Paip2A inhibits translation by competitively binding to the RNA recognition motifs of PABPC1 and promoting its dissociation from the poly(A) tail. The Journal of biological chemistry. 2022. 298. 5. 101844-101844
Matsumura K, Shimomura T, Kubo Y, Oka T, Kobayashi N, Imai S, Yanase N, Akimoto M, Fukuda M, Yokogawa M, et al. Mechanism of hERG inhibition by gating-modifier toxin, APETx1, deduced by functional characterization. BMC Molecular and Cell Biology. 2021. 22. 3. 3-3
Kano H, Toyama Y, Imai S, Iwahashi Y, Mase Y, Yokogawa M, Osawa M, Shimada I. Structural mechanism underlying G protein family-specific regulation of G protein-gated inwardly rectifying potassium channel. Nature Communications. 2019. 10. 1
Yuki Toyama, Yoko Mase, Hanaho Kano, Mariko Yokogawa, Masanori Osawa, Ichio Shimada. Nuclear magnetic resonance approaches for characterizing protein-protein interactions. Methods in Molecular Biology. 2018. 1684. 115-128
Osawa Masanori, Mase Yoko, Yokoagawa Mariko, Takeuchi Koh, Shimada Ichio. 2SBP-05 Structural Basis for Regulation of G Protein-activated Inwardly Rectifying Potassium Channel 1 (GIRK1) by G Proteins(New Development of Structural Cell Biology in Signal Transduction,Symposium,The 52th Annual Meeting of the Biophysical Society of. Seibutsu Butsuri. 2014. 54. 1
