Yokogawa Mariko

Research field (2)： Structural biochemistry , Pharmaceuticals - analytical and physicochemistry

Research keywords (6)：ウイルス感染症 , 膜タンパク質 , 翻訳因子 , 構造生物学 , イオンチャネル , NMR

Research theme for competitive and other funds (6)：

2021 - 2024 電位依存性イオンチャネルの機能構造と構造間遷移機構の解析による動作機構解明
2021 - 2024 B型肝炎ウイルスの肝細胞侵入・増殖機構の構造基盤と立体構造に基づく創薬
2018 - 2021 B型肝炎ウイルスの肝細胞侵入および増殖機構の構造生物学的解析
2017 - 2020 Functional regulation of voltage-gated ion channels targeting the voltage sensor
2016 - 2018 Structural basis for hepatitis B virus infection

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Papers (32)：

Martina Stillinovic, Mayuresh Anant Sarangdhar, Nicola Andina, Aubry Tardivel, Frédéric Greub, Giuseppe Bombaci, Camille Ansermet, Marco Zatti, Dipanjali Saha, Jieyu Xiong, et al. Ribonuclease inhibitor and angiogenin system regulates cell type-specific global translation. Science advances. 2024. 10. 22. eadl0320
Shimizu Y, Yonezawa T, Bao Y, Sakamoto J, Yokogawa M, Furuya T, Osawa M, Ikeda K. Applying deep learning to iterative screening of medium-sized molecules for protein-protein interaction-targeted drug discovery. Chemical Communications. 2023. 59. 44. 6722-6725
Miura M, Sakaue F, Matsuno H, Morita K, Yoshida A, Hara R.I, Nishimura R, Nishida Y, Yokogawa M, Osawa M, et al. TDP-43 N-terminal domain dimerisation or spatial separation by RNA binding decreases its propensity to aggregate. FEBS Letters. 2023. 597. 12. 1667-1676
Sagae T, Yokogawa M, Sawazaki R, Ishii Y, Hosoda N, Hoshino SI, Imai S, Shimada I, Osawa M. Paip2A inhibits translation by competitively binding to the RNA recognition motifs of PABPC1 and promoting its dissociation from the poly(A) tail. The Journal of biological chemistry. 2022. 298. 5. 101844-101844
Kazuki Matsumura, Mariko Yokogawa, Masanori Osawa. Peptide Toxins Targeting KV Channels. Handbook of Experimental Pharmacology. 2021. 267. 481-505

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MISC (3)：

Yuki Toyama, Yoko Mase, Hanaho Kano, Mariko Yokogawa, Masanori Osawa, Ichio Shimada. Nuclear magnetic resonance approaches for characterizing protein-protein interactions. Methods in Molecular Biology. 2018. 1684. 115-128
Osawa Masanori, Mase Yoko, Yokoagawa Mariko, Takeuchi Koh, Shimada Ichio. 2SBP-05 Structural Basis for Regulation of G Protein-activated Inwardly Rectifying Potassium Channel 1 (GIRK1) by G Proteins(New Development of Structural Cell Biology in Signal Transduction,Symposium,The 52th Annual Meeting of the Biophysical Society of. Seibutsu Butsuri. 2014. 54. 1
吉田直樹, 小橋川敬博, 原田幸祐, 小椋賢治, 横川真梨子, 稲垣冬彦. イノシトールリン脂質を組み込んだナノディスクの調製とタンパク質-膜相互作用解析への応用. Abstr Annu Meet NMR Soc Jpn. 2010. 49th. 150-153

Books (2)：

Peptide Toxins Targeting KV Channels
Handbook of Experimental Pharmacology 2021
Nuclear magnetic resonance approaches for characterizing protein-protein interactions
Methods in Molecular Biology 2018

Lectures and oral presentations (48)：

Structural insights into the inhibitory mechanism of transcription factor FOXO3a by phosphorylation and 14-3-3ζ
(第46回日本分子生物学会年会 2023)
Structural mechanism for the acceleration of the Caf1-dependent deadenylation of mRNA by BTG2
(第46回日本分子生物学会年会 2023)
タンパク質-タンパク質相互作用をターゲットとした感染阻害大環状物質の探索と構造活性相関解析
(第51回構造活性相関シンポジウム 2023)
NMR-based drug discovery of the entry inhibitor of SARS-CoV-2 that directly binds to hACE2
(第62回NMR討論会 2023)
14-3-3ζによる転写因子FOXO3aの阻害メカニズムの解明
(第62回NMR討論会 2023)

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