Rchr
J-GLOBAL ID：201201031307953648   Update date: Nov. 01, 2024

Moriguchi Takashi

モリグチ タカシ | Moriguchi Takashi
Affiliation and department：
Tohoku Medical and Pharmaceutical University

About Tohoku Medical and Pharmaceutical University


Other affiliations (1)：
Homepage URL  (2)： http://www.tohoku-mpu.ac.jp/medicine/about/dmbc/ ,  http://db.tohoku.ac.jp/whois/detail/f8380e4350246be3b18713c5b958049c.html
Research field  (1)： Medical biochemistry
Research keywords  (8)： 敗血症 ,  マスト細胞 ,  アレルギー ,  炎症 ,  肺ガン ,  腎臓病 ,  酸化ストレス ,  GATA
Research theme for competitive and other funds  (12)：
  • 2022 - 2025 Therapeutic strategy against infectious and inflammatory diseases by targeting master regulators of mast cells and eosinophils
  • 2021 - 2024 好酸球性多発血管炎性肉芽腫症におけるGATA転写因子の病態への関与
  • 2019 - 2022 Selective ablation of mast cells and eosinophils by GATA factor inhibition for asthma therapy
  • 2018 - 2020 Epigenetic regulation of cytokiine gene expression underlying inflammatory diseases
  • 2016 - 2019 Proinflammatory role of renal collecting duct cells in kidney disease
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Papers (66)：
  • Moyuru Hayashi, Shin'ya Ohmori, Yoshiko Kawai, Takashi Moriguchi. Endothelial GATA3 is involved in coagulofibrinolytic homeostasis during endotoxin sepsis. Experimental animals. 2024
  • Satoshi Uemura, Takahiro Mochizuki, Yusuke Kato, Tetsuo Mioka, Riseko Watanabe, Mai Fuchita, Mao Yamada, Yoichi Noda, Takashi Moriguchi, Fumiyoshi Abe. Mtc6/Ehg2 is a novel endoplasmic reticulum-resident glycoprotein essential for high-pressure tolerance. Journal of biochemistry. 2024
  • Tomomi Watanabe-Asaka, Moyuru Hayashi, Takuya Harada, Satoshi Uemura, Jun Takai, Yasuhiro Nakamura, Takashi Moriguchi, Yoshiko Kawai. Perturbed collagen metabolism underlies lymphatic recanalization failure in Gata2 heterozygous deficient mice. Journal of biochemistry. 2024
  • Xing Xu, Tomohiko Fukuda, Jun Takai, Sayaka Morii, Yuhan Sun, Jianwei Liu, Shiho Ohno, Tomoya Isaji, Yoshiki Yamaguchi, Miyako Nakano, et al. Exogenous L-fucose attenuates neuroinflammation induced by lipopolysaccharide. The Journal of biological chemistry. 2023. 105513-105513
  • Shin'ya Ohmori, Jun Takai, Satoshi Uemura, Akihito Otsuki, Tetsuya Mori, Kinuko Ohneda, Takashi Moriguchi. The Il6 -39 kb enhancer containing clustered GATA2- and PU.1-binding sites is essential for Il6 expression in murine mast cells. iScience. 2022. 25. 9. 104942-104942
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MISC (95)：
  • 原田拓弥, 浅香智美, 林もゆる, 高井淳, 上村聡志, 森口尚, 河合住子. リンパ管再疎通におけるGata2ヘテロ変異と線維芽細胞の関与. 日本生理学雑誌(Web). 2024. 86. 1
  • 河合 佳子, 浅香 智美, 林 もゆる, 高井 淳, 上村 聡志, 中村 保宏, 森口 尚. Gata2ヘテロ欠損マウスにおけるリンパ管再疎通障害を惹起するコラーゲン代謝異常について. 脈管学. 2023. 63. Suppl. S211-S211
  • 高井 淳, 植木 陽向, 大森 慎也, 大根田 絹子, 上村 聡志, 森口 尚. 転写因子GATA2は炎症関連遺伝子座のクロマチン構造を変換し発現活性化に寄与する. 日本生化学会大会プログラム・講演要旨集. 2023. 96回. [2P-407]
  • 浅香智美, 林もゆる, 高井淳, 上村聡志, 森口尚, 河合佳子. Collagen improves the retardation of lymphatic recanalization in Gata2 heterozygous mice. リンパ学. 2023. 46. 2
  • 河合佳子, 浅香智美, 林もゆる, 高井淳, 上村聡志, 中村保宏, 森口尚. Gata2ヘテロ欠損マウスにおけるリンパ管再疎通障害を惹起するコラーゲン代謝異常について. 脈管学(Web). 2023. 63. supplement
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Books (2)：
  • 南山堂医学大辞典
    南山堂 2011
  • Hematopoietic Stem Cell Biology
    Springer 2008
Lectures and oral presentations  (105)：
  • Real-time in vivo monitoring of inflammatory status exploiting human interleukin-6 BAC luciferase transgenic mice.
    (4th International Symposium on Environmental Response 2014)
  • Transcription factor Nrf2 adversely affects pregnancy-induced hypertension.
    (4th International Symposium on Environmental Response. 2014)
  • Myeloid lineage-specific deletion of antioxidant system enhances tumor metastasis to the lung.
    (4th International Symposium on Environmental Response. 2014)
  • Nrf2-deficiency attenuates malignant transformation of benign lung adenoma through restricting Kras mutagenesis.
    (4th International Symposium on Environmental Response. 2014)
  • Human GATA1 BAC DNA harboring a chromatin insulator recapitulates the spatiotemporal expression pattern of mouse Gata1 and rescues the hematopoietic deficiency in Gata1.05 knockdown mutant mice
    (The 19th Hemoglobin Switching Conference 2014)
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Education (2)：
  • 1997 - 2001 University of Tsukuba
  • 1988 - 1994 University of Tsukuba School of Medicine
Professional career (1)：
  • Ph.D. (University of Tsukuba)
Work history (6)：
  • 2016/04 - 現在 Tohoku Medical and Pharmaceutical University
  • 2007/04 - 2016/03 Tohoku University Graduate School of Medicine, Department of Medical Sciences, Physiological Sciences,Medical Biochemistry Lecturer
  • 2006/08 - 2007/03 筑波大学先端学際領域研究センター
  • 2003/04 - 2006/08 University of Michigan Medical School Cell & Developmental Biology Research Fellow
  • 2001/04 - 2003/03 University of Tsukuba Institute of Basic Medical Sciences
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Committee career (1)：
  • 2018/04 - 現在 日本生化学会 評議員
Awards (4)：
  • 2015/05 - 日本生化学会東北支部 奨励賞
  • 2014 - 宮城県医師会医学奨励賞
  • 2014 - 東北大学医学部奨学賞
  • 2008 - 匂坂賞
Association Membership(s) (2)：
日本分子生物学会 ,  日本生化学会
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