Moriguchi Takashi

モリグチタカシ | Moriguchi Takashi

Affiliation and department：
Other affiliations (1)：

Research field (1)： Medical biochemistry

Research keywords (8)：敗血症 , マスト細胞 , アレルギー , 炎症 , 肺ガン , 腎臓病 , 酸化ストレス , GATA

Research theme for competitive and other funds (12)：

2022 - 2025 Therapeutic strategy against infectious and inflammatory diseases by targeting master regulators of mast cells and eosinophils
2021 - 2024 好酸球性多発血管炎性肉芽腫症におけるGATA転写因子の病態への関与
2019 - 2022 Selective ablation of mast cells and eosinophils by GATA factor inhibition for asthma therapy
2018 - 2020 Epigenetic regulation of cytokiine gene expression underlying inflammatory diseases
2016 - 2019 Proinflammatory role of renal collecting duct cells in kidney disease

Show all

Papers (65)：

Satoshi Uemura, Takahiro Mochizuki, Yusuke Kato, Tetsuo Mioka, Riseko Watanabe, Mai Fuchita, Mao Yamada, Yoichi Noda, Takashi Moriguchi, Fumiyoshi Abe. Mtc6/Ehg2 is a novel endoplasmic reticulum-resident glycoprotein essential for high-pressure tolerance. Journal of biochemistry. 2024
Tomomi Watanabe-Asaka, Moyuru Hayashi, Takuya Harada, Satoshi Uemura, Jun Takai, Yasuhiro Nakamura, Takashi Moriguchi, Yoshiko Kawai. Perturbed collagen metabolism underlies lymphatic recanalization failure in Gata2 heterozygous deficient mice. Journal of biochemistry. 2024
Xing Xu, Tomohiko Fukuda, Jun Takai, Sayaka Morii, Yuhan Sun, Jianwei Liu, Shiho Ohno, Tomoya Isaji, Yoshiki Yamaguchi, Miyako Nakano, et al. Exogenous L-fucose attenuates neuroinflammation induced by lipopolysaccharide. The Journal of biological chemistry. 2023. 105513-105513
Shin'ya Ohmori, Jun Takai, Satoshi Uemura, Akihito Otsuki, Tetsuya Mori, Kinuko Ohneda, Takashi Moriguchi. The Il6 -39 kb enhancer containing clustered GATA2- and PU.1-binding sites is essential for Il6 expression in murine mast cells. iScience. 2022. 25. 9. 104942-104942
Satoshi Uemura, Takashi Moriguchi. Pleiotropic roles of N-glycans for enzyme activities and stabilities of MIPC synthases, Csh1 and Sur1/Csg1, in Saccharomyces cerevisiae. Glycobiology. 2022

ｍore...

MISC (95)：

原田拓弥, 浅香智美, 林もゆる, 高井淳, 上村聡志, 森口尚, 河合住子. リンパ管再疎通におけるGata2ヘテロ変異と線維芽細胞の関与. 日本生理学雑誌(Web). 2024. 86. 1
河合佳子, 浅香智美, 林もゆる, 高井淳, 上村聡志, 中村保宏, 森口尚. Gata2ヘテロ欠損マウスにおけるリンパ管再疎通障害を惹起するコラーゲン代謝異常について. 脈管学. 2023. 63. Suppl. S211-S211
高井淳, 植木陽向, 大森慎也, 大根田絹子, 上村聡志, 森口尚. 転写因子GATA2は炎症関連遺伝子座のクロマチン構造を変換し発現活性化に寄与する. 日本生化学会大会プログラム・講演要旨集. 2023. 96回. [2P-407]
浅香智美, 林もゆる, 高井淳, 上村聡志, 森口尚, 河合佳子. Collagen improves the retardation of lymphatic recanalization in Gata2 heterozygous mice. リンパ学. 2023. 46. 2
河合佳子, 浅香智美, 林もゆる, 高井淳, 上村聡志, 中村保宏, 森口尚. Gata2ヘテロ欠損マウスにおけるリンパ管再疎通障害を惹起するコラーゲン代謝異常について. 脈管学(Web). 2023. 63. supplement

ｍore...

Books (2)：

Lectures and oral presentations (105)：

Real-time in vivo monitoring of inflammatory status exploiting human interleukin-6 BAC luciferase transgenic mice.
(4th International Symposium on Environmental Response 2014)
Transcription factor Nrf2 adversely affects pregnancy-induced hypertension.
(4th International Symposium on Environmental Response. 2014)
Myeloid lineage-specific deletion of antioxidant system enhances tumor metastasis to the lung.
(4th International Symposium on Environmental Response. 2014)
Nrf2-deficiency attenuates malignant transformation of benign lung adenoma through restricting Kras mutagenesis.
(4th International Symposium on Environmental Response. 2014)
Human GATA1 BAC DNA harboring a chromatin insulator recapitulates the spatiotemporal expression pattern of mouse Gata1 and rescues the hematopoietic deficiency in Gata1.05 knockdown mutant mice
(The 19th Hemoglobin Switching Conference 2014)

ｍore...

Education (2)：

Professional career (1)：

Work history (9)：

2016/04 - 現在 Tohoku Medical and Pharmaceutical University
2007/04 - 2016/03 Tohoku University Graduate School of Medicine, Department of Medical Sciences, Physiological Sciences,Medical Biochemistry Lecturer
2006/08 - 2007/03 筑波大学先端学際領域研究センター博士研究員
2003/04 - 2006/08 University of Michigan Medical School Cell & Developmental Biology Research Fellow
2001/04 - 2003/03 University of Tsukuba Institute of Basic Medical Sciences

Show all

Committee career (1)：

Awards (4)：

Association Membership(s) (2)：

日本分子生物学会 , 日本生化学会

※ Researcher’s information displayed in J-GLOBAL is based on the information registered in researchmap. For details, see here.

Return to Previous Page