Ohbo Kazuyuki

オオボカズユキ | Ohbo Kazuyuki

Affiliation and department：
Job title： Associate Professor
Homepage URL (1)： http://www-user.yokohama-cu.ac.jp/~finemorp/

Research field (4)： Medical biochemistry , Systems genomics , Genomics , Anatomy

Research keywords (9)： lung development , Germ cell development , 自己複製 , 幹細胞 , エピジェネティクス , regenerative medicine , self-renew , Stem cell , Epigenetics

Research theme for competitive and other funds (15)：

2022 - 2024 Effects of paternal histone modification integrated in undifferentiated spermatogonial during early embryogenesis
2019 - 2023 Analysis of epigenome infertiity mechanism by the state-of-art single cell and ultrtrace histone modification methods
2019 - 2023 Identification and dynamic analysis of true stem cells in testicular stem cells using the latest single cell analysis method
2020 - 2022 Effects of histone modification primed in spermatogonia stem cells on the next generation totipotency program
2015 - 2018 International joint research on gamete formation through the cutting-edge analysis system

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Papers (48)：

Hiromi Fukuda, Daisuke Yamaguchi, Kristofor Nyquist, Yasushi Yabuki, Satoko Miyatake, Yuri Uchiyama, Kohei Hamanaka, Ken Saida, Eriko Koshimizu, Naomi Tsuchida, et al. Father-to-offspring transmission of extremely long NOTCH2NLC repeat expansions with contractions: genetic and epigenetic profiling with long-read sequencing. Clinical Epigenetics. 2021. 13. 1. 204-204
Yuki Takada, Ruken Yaman-Deveci, Takayuki Shirakawa, Jafar Sharif, Shin-ichi Tomizawa, Fumihito Miura, Takashi Ito, Michio Ono, Kuniko Nakajima, Yoko Koseki, et al. Maintenance DNA methylation in pre-meiotic germ cells regulates meiotic prophase by facilitating homologous chromosome pairing. Development. 2021. 148. 10
Yuki Kobayashi, Shin-Ichi Tomizawa, Michio Ono, Kazushige Kuroha, Keisuke Minamizawa, Koji Natsume, Selma Dizdarević, Ivana Dočkal, Hiromitsu Tanaka, Tatsukata Kawagoe, et al. Tsga8 is required for spermatid morphogenesis and male fertility in mice. Development (Cambridge, England). 2021. 148. 8
Naoki Nishiyama, Masahiro Masuo, Yoshihisa Nukui, Tomoya Tateishi, Mitsuhiro Kishino, Ukihide Tateishi, Kaori Morota, Kazuyuki Ohbo, Yasunari Miyazaki. Human epididymis protein 4 is a new biomarker to predict the prognosis of progressive fibrosing interstitial lung disease. Respiratory investigation. 2021. 59. 1. 90-98
Noriko Miyake, Hidehisa Takahashi, Kazuyuki Nakamura, Bertrand Isidor, Yoko Hiraki, Eriko Koshimizu, Masaaki Shiina, Kazunori Sasaki, Hidefumi Suzuki, Ryota Abe, et al. Gain-of-Function MN1 Truncation Variants Cause a Recognizable Syndrome with Craniofacial and Brain Abnormalities. American journal of human genetics. 2020. 106. 1. 13-25

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MISC (8)：

富澤信一, 小林裕貴, PETERS Antoine H.F.M., ANASTASSIADIS Konstantinos, STEWART A Francis, 関真秀, 鈴木穣, CLARK Stephen, KELSEY Gavin, 大保和之. 精子幹細胞分化系列におけるエピジェネティックおよびトランスクリプトームの解析. 日本分子生物学会年会プログラム・要旨集(Web). 2019. 42nd
久保直樹, 藤英博, 白根健次郎, 白川峰征, 小林久人, 佐藤哲也, 曾根秀利, 佐藤康人, 富澤信一, 鶴崎美徳, et al. 新生仔マウスの精原幹細胞の形成と分化における全ゲノムDNAメチル化およびトランスクリプトーム解析. 日本生化学会大会・日本分子生物学会年会合同大会講演要旨集. 2015. 88回・38回. [1P0606]-[1P0606]
OBO KAZUYUKI. エピジェネティクスの視点から見た精原幹細胞分化. 日本生殖医学会雑誌. 2015. 60. 1/2. 89
OBO KAZUYUKI. 生殖細胞からみた幹細胞の分化制御システム. 横浜医学. 2013. 64. 1. 13-19
Shin-Ichi Yamashita, Keita Tokuishi, Toshihiko Moroga, Takafumi Hashimoto, Mirei Kamei, Shuji Suehiro, Kiyoshi Ono, Satoshi Yamamoto, Masao Chujo, Kazuyuki Ohbo, et al. HE4 EXPRESSION IS ASSOCIATED WITH WORSE PROGNOSIS IN PULMONARY ADENOCARCINOMA. JOURNAL OF THORACIC ONCOLOGY. 2011. 6. 6. S972-S973

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Lectures and oral presentations (11)：

ヒストンメチル化酵素による精巣幹細胞分化制御とその意味
(第122回日本解剖学会総会・全国学術集会シンポジウム9 精子形成研究のUpdate 2017)
精子幹細胞分化に関わるゲノム修飾機構の解析
(第57回日本組織細胞化学会総会・学術集会シンポジウム4 配偶子形成・受精・着床の最先端研究 2016)
WAP-type four-disulfide core (WFDC) domain family分子群の肺における分子機能について
(第56回日本呼吸器学会学術講演会サテライトシンポジウム 2016)
ゲノム修飾からみた成体精巣幹細胞分化機構
(第121回日本解剖学会総会・全国学術集会シンポジウム“精巣研究の最前線” 2016)
エピジェネティクスの視点から見た精原幹細胞分化
(第60回日本生殖医学会シンポジウム 1『生殖細胞の産生制御機構』 2015)

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Association Membership(s) (3)：

JAPANESE SOCIETY OF DEVELOPMENTAL BIOLOGISTS , JAPAN SOCIETY OF HISTOCHEMISTRY AND CYTOCHEMISTRY , THE JAPANESE ASSOCIATION OF ANATOMISTS

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