Rchr
J-GLOBAL ID：201201043267686895
Update date: Sep. 04, 2024
Nakamura Fumio
Nakamura Fumio | Nakamura Fumio
Affiliation and department：
Job title：
Professor and Head of Division
Homepage URL (1)：
http://www.twmu.ac.jp/
Research field (4)：
Medical biochemistry
, Pharmacology
, Neuroscience - general
, Neuroanatomy and physiology
Research keywords (11)：
trimeric G-protein
, G-protein coupled receptor
, protein tyrosine phosphatase
, Semaphorin
, axon guidance molecule
, tyrosine phosphorylation/dephosohorylation
, synapse formation
, 細胞内情報伝達機構
, 神経回路形成
, molecular mechanism of signal transduction
, axon guidance
Research theme for competitive and other funds (16)：
- 2022 - 2026 An identification of the signaling pathway involving in Sema3A-induced breakdown of the asymmetric distribution in the developing neuron's membrane
- 2022 - 2025 赤血球のセマフォリン7Aを標的とした耐性のない抗マラリア治療法を探る
- 2020 - 2023 マスト細胞分泌顆粒プロテオミクスを活用したアレルギー治療標的候補遺伝子の探索
- 2016 - 2019 Sema3A-PTPdelta signaling regulates cortical dendritic growth
- 2015 - 2018 Functional analysis of DOPAergic transmission in cardiovascular system
- 2012 - 2015 Interaction of CRMP1 and Filamin-A regulates F-actin-cytoskeleton.
- 2012 - 2015 Functional of GPR143, a novel G protein-coupled receptor for L-DOPA
- 2010 - 2012 Aberrant epidermal expression of semaphorin 3A in pruritic skin diseases and development of new therapeutic drugs for pruritus
- 2010 - 2011 Exploring Optical Navigation of Neurite Outgrowth
- 2005 - 2009 The role of CRMP family proteins in the establishment of neural tissue architectures
- 2006 - 2008 Biological analysis of a novel axon guidance molecule, LOTUS/cep68
- 2004 - 2005 Functional analysis of novel G-coupled receptor candidate for L-DOPA and structural determination of its ligands
- 2003 - 2004 The role of protein tyrosine phosphatase δ in axon guidance
- 2002 - 2003 Isolation and characterization of a receptor candidate for L-DOPA in C.elegans
- 2001 - 2002 The relation between LAR class protein tyrosine phosphates and Semaphorin-Plexin signaling
- 2000 - 2000 軸索伸長抑制因子Nogoの受容体同定とセマフォリンの細胞内情報伝達系の解明
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Papers (101)：
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Ethiraj Ravindran, Nobuto Arashiki, Lena-Luise Becker, Kohtaro Takizawa, Jonathan Lévy, Thomas Rambaud, Konstantin L Makridis, Yoshio Goshima, Na Li, Maaike Vreeburg, et al. Monoallelic CRMP1 gene variants cause neurodevelopmental disorder. eLife. 2022. 11
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Yuko Kawamoto, Mikiko Tada, Tetsuya Asano, Haruko Nakamura, Aoi Jitsuki-Takahashi, Hiroko Makihara, Shun Kubota, Shunta Hashiguchi, Misako Kunii, Toshio Ohshima, et al. Phosphorylated CRMP1, axon guidance protein, is a component of spheroids and is involved in axonal pathology in amyotrophic lateral sclerosis. Frontiers in Neurology. 2022. 13
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Katsuaki Ieguchi, Masabumi Funakoshi, Taishi Mishima, Kohtaro Takizawa, Tsutomu Omori, Fumio Nakamura, Makoto Watanabe, Mayumi Tsuji, Yuji Kiuchi, Shinichi Kobayashi, et al. The Sympathetic Nervous System Contributes to the Establishment of Pre-Metastatic Pulmonary Microenvironments. International journal of molecular sciences. 2022. 23. 18
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Tetsuya Asano, Haruko Nakamura, Yuko Kawamoto, Mikiko Tada, Yayoi Kimura, Hiroshi Takano, Ryoji Yao, Hiroya Saito, Takuya Ikeda, Hiroyasu Komiya, et al. Inhibition of Crmp1 phosphorylation at Ser522 ameliorates motor function and neuronal pathology in amyotrophic lateral sclerosis model mice. eNeuro. 2022. 9. 3
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Junko Ichikawa, Ichiro Koshino, Nobuto Arashiki, Fumio Nakamura, Makiko Komori. Storage-Related Changes in Autologous Whole Blood and Irradiated Allogeneic Red Blood Cells and Their Ex Vivo Effects on Deformability, Indices, and Density of Circulating Erythrocytes in Patients Undergoing Cardiac Surgery With Cardiopulmonary Bypass. Journal of Cardiothoracic and Vascular Anesthesia. 2022. 36. 3. 855-861
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MISC (82)：
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五嶋良郎, 野本宗孝, 野本宗孝, 山下直也, 山下直也, 實木(高橋)葵, 實木(高橋)葵, 中村治子, 中村治子, 槙原弘子, et al. 統合失調症患者由来血液検体におけるCRMP2およびそのリン酸化修飾レベルの変化. 臨床薬理. 2019. 50. Supplement
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Hiroko Makihara, Shiori Nakai, Aoi Jitsuki-Takahashi, Haruko Nakamura, Naoya. Yamashita, Hiroshi Kiyonari, Go Shioi, Fumio Nakamura, Fumiaki Tanaka, Yoshio Goshima. Collapsin response mediator protein 1 (CRMP1) and CRMP2 mediate Semaphorin3A signaling through distinct pathway in vivo. JOURNAL OF PHARMACOLOGICAL SCIENCES. 2016. 130. 3. S155-S155
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中村史雄, 五嶋良郎, 相原道子. 皮膚における神経免疫クロストーク. 最新医学. 2016. 71. 2
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上田傑, 増川太輝, 古賀資和, 中村史雄, 五嶋良郎. L-DOPAによって誘発される行動薬理学的変化の解析. 日本薬理学会関東部会プログラム・要旨集. 2015. 132nd. 88
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北村慧, 増川太輝, 古賀資和, 中村史雄, 五嶋良郎. GPR143遺伝子欠損マウスにおけるドパミン受容体作動薬の効果. 日本薬理学会関東部会プログラム・要旨集. 2015. 133rd. 44
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Lectures and oral presentations (6)：
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PTPdelta mediates Semaphorin-3A-induced dendritic growth of cortical pyramidal neurons
(Workshop on Frontiers in Phosphatase Research and Drug Discovery 2018)
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CRMP1 phosphorylation at Tyr504 participates in Sema3A-signaling
(Cold Spring Harbor Lab, Molecular Mechanism of Neuronal connectivity 2018)
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Protein tyrosine phosphatase delta mediates Sema3A-induced cortical basal dendritic formation
(Cold Spring Harbor Lab, Axon guidance meeting 2016)
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Sema3A(-/-) マウスにおける海馬 CA1 錐体細胞の形態学的解析
(日本神経科学大会 2008)
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Morphological analysis of hippocampal CA1 pyramidal neurons in sema3A(-/-) mice
(Japan Neuroscience Society 2008)
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Professional career (1)：
Work history (1)：
- Yokohama City University School of Medicine, Medical Course, Pharmacology and Neurobiology, Medical Studies Associate Professor
Committee career (1)：
Association Membership(s) (5)：
日本薬理学会
, THE MOLECULAR BIOLOGY SOCIETY OF JAPAN
, THE JAPAN NEUROSCIENCE SOCIETY
, THE JAPANESE SOCIETY FOR NEUROCHEMISTRY
, THE JAPANESE BIOCHEMICAL SOCIETY
