Ikeguchi Mitsunori

イケグチミツノリ | Ikeguchi Mitsunori

Affiliation and department：
Job title： Professor
Homepage URL (1)： http://www.tsurumi.yokohama-cu.ac.jp/bioinfo/

Research field (3)： Biological, health, and medical informatics , Bio-, chemical, and soft-matter physics , Biophysics

Research keywords (3)：バイオインフォマティクス , 分子シミュレーション , 生物物理学

Research theme for competitive and other funds (21)：

2018 - 2023 生体発動分子の機能発現に関する構造ダイナミクス研究
2013 - 2016 Molecular simulation study on the rotation mechanism of V-ATPase
2011 - 2013 Pループ型ATP加水分解酵素の機能発現機構の解明
2011 - 2012 Structure-function relationships of Rad51-Swi5-Sfr1 complex for homologous recombination
2010 - 2012 Study on rotation mechanisms of F1 molecular motor using molecular simulations

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Papers (216)：

Masao Inoue, Tomohiko Hayashi, Satoshi Yasuda, Minoru Kato, Mitsunori Ikeguchi, Takeshi Murata, Masahiro Kinoshita. Statistical-Mechanics Analyses on Thermodynamics of Protein Folding Constructed by Privalov and Co-Workers. The journal of physical chemistry. B. 2024. 128. 41. 10110-10125
Mitsugu Araki, Toru Ekimoto, Kazuhiro Takemura, Shigeyuki Matsumoto, Yunoshin Tamura, Hironori Kokubo, Gert-Jan Bekker, Tsutomu Yamane, Yuta Isaka, Yukari Sagae, et al. Molecular Dynamics Unveils Multiple-Site Binding of Inhibitors with Reduced Activity on the Surface of Dihydrofolate Reductase. Journal of the American Chemical Society. 2024
Kylie Chinner, Niklas Grabicki, Rei Hamaguchi, Mitsunori Ikeguchi, Kazushi Kinbara, Sayaka Toyoda, Kohei Sato, Oliver Dumele. Nanohoops in Membranes: Confined Supramolecular Spaces within Phospholipid Bilayer Membranes. Chemical Science. 2024
Jae-Hyun Park, Kouki Kawakami, Naito Ishimoto, Tatsuya Ikuta, Mio Ohki, Toru Ekimoto, Mitsunori Ikeguchi, Dong-Sun Lee, Young-Ho Lee, Jeremy R H Tame, et al. Structural basis for ligand recognition and signaling of hydroxy-carboxylic acid receptor 2. Nature communications. 2023. 14. 1. 7150-7150
Tsutomu Yamane, Takahiro Nakayama, Toru Ekimoto, Masao Inoue, Keigo Ikezaki, Hiroshi Sekiguchi, Masahiro Kuramochi, Yasuo Terao, Ken Judai, Minoru Saito, et al. Comparison of the Molecular Motility of Tubulin Dimeric Isoforms: Molecular Dynamics Simulations and Diffracted X-ray Tracking Study. International Journal of Molecular Sciences. 2023. 24. 20. 15423-15423

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MISC (88)：

Nagata T, Yamada T, Hayashi T, Hikiri S, Kobayashi N, Ikeguchi M, Katahira M, Kinoshita M, Yanagawa H. STRUCTURAL AND PHYSICAL BASIS FOR THE HIGHER AFFINITY TO ONCOPROTEIN MDM2 OF A PEPTIDE SELECTED WITH MRNA DISPLAY OVER TUMOR SUPPRESSOR P53. 64th Annual Meeting of the Biophysical Society, San Diego, 2020.2.15-19. 2020
浴本亨, 小甲裕一, 苙口友隆, 池口満徳, 池口満徳. X線小角散乱と分子動力学シミュレーションを組み合わせた生体分子の溶液構造解析. アンサンブル. 2020. 22. 3
佐藤美和, 中川寛之, 小甲裕一, 宮口郁子, 鹿島亜希子, 馬彪, 徳久淳師, 大田雅照, 池口満徳, 池口満徳. 深層学習による低解像度電子密度データからの構造予測. 日本細胞生物学会大会(Web). 2019. 71st
宮口郁子, 鹿島亜季子, 佐藤美和, 中田一人, 馬彪, 松本篤幸, 徳久淳師, 大田雅照, 池口満徳. AI用学習データ作成のための高・低分解能の蛋白質結晶構造比較. 日本細胞生物学会大会(Web). 2019. 71st
馬場剛史, 小甲裕一, 佐藤美和, 中川寛之, 宮口郁子, MA Biao, 松本篤幸, 徳久淳師, 大田雅照, 池口満徳, et al. Research on pocket prediction using 3D-CNN. 構造活性相関シンポジウム講演要旨集. 2019. 47th (CD-ROM)

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Books (4)：

実験医学増刊構造生命科学で何がわかるのか何ができるのか
羊土社 2014
Protein Conformational Dynamics
Springer Cham Heidelberg New York Dordrecht London 2014
1分子ナノバイオ計測
化学同人 2014
最新分子マシンナノで働く“高度な機械”を目指して
化学同人 2008

Lectures and oral presentations (97)：

Finite-size effect on the charging free energy in the alchemical perturbation and “Warp Drive” method
(Biophysical society 62th Annual Meeting 2018)
In silico binding affinity analysis for phosphodiesterase-10A inhibitors
(情報計算科学生物学会2017年大会 2017)
In silico protein design for functional modification of the photoactivated adenylate cyclase
(情報計算科学生物学会2017年大会 2017)
Finite-size effect on the charging free energy in the alchemical perturbation and ``warp drive'' method
(情報計算科学生物学会2017年大会 2017)
Apo- and antagonist-binding structures of vitamin D receptor ligand-binding domain elucidated by SAXS experiments and MD simulations
(第55回日本生物物理学会年会 2017)

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Education (2)：

- 1994 The University of Tokyo
- 1989 The University of Tokyo The Faculty of Engineering Department of Mathematical Engineering and Information Physics

Professional career (1)：

博士(農学) (東京大学)

Work history (2)：

Yokohama City University International College of Arts and Sciences Medical Life Science Graduate School of Medical Life Science Department of Medical Life Science Professor
東京大学農学部助手

Association Membership(s) (4)：

米国生物物理学会 , 日本物理学会 , 日本蛋白質科学会 , 日本生物物理学会

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