Goto Yuki

ゴトウユウキ | Goto Yuki

Affiliation and department：
Job title： Professor
Homepage URL (2)： http://www.chem.s.u-tokyo.ac.jp/users/bioorg/member/Goto.html , http://www.chem.s.u-tokyo.ac.jp/users/bioorg/English/member/Goto.html

Research field (3)： Applied biochemistry , Bioorganic chemistry , Biochemistry

Research keywords (9)： in vitro selection , 擬天然物 , 試験管内生合成系 , 非天然アミノ酸 , 遺伝暗号のリプログラミング , ペプチド , 翻訳合成 , ペプチドライブラリー , リボザイム

Research theme for competitive and other funds (12)：

2020 - 2024 Development of prenylated peptides interacting with intracellular targets
2019 - 2023 高分子間相互作用を制御する合成機能分子を論理的・効率的に創出する方法論の確立
2019 - 2022 Development of chimeric peptide ligands using a macrocyclic scaffold found in natural products
2016 - 2021 Synthetic biology of pseudo-natural products by artificial in vitro biosynthesis
2018 - 2020 特定の立体構造を有する生物活性中分子の汎用創製手法の確立

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Papers (94)：

Sumika Inoue, Dinh Thanh Nguyen, Keisuke Hamada, Rika Okuma, Chikako Okada, Masahiro Okada, Ikuro Abe, Toru Sengoku, Yuki Goto, Hiroaki Suga. De Novo Discovery of Pseudo-Natural Prenylated Macrocyclic Peptide Ligands. Angewandte Chemie International Edition. 2024
Alexander A Vinogradov, Yue Zhang, Keisuke Hamada, Shunsuke Kobayashi, Kazuhiro Ogata, Toru Sengoku, Yuki Goto, Hiroaki Suga. A Compact Reprogrammed Genetic Code for De Novo Discovery of Proteolytically Stable Thiopeptides. Journal of the American Chemical Society. 2024. 146. 12. 8058-8070
Ayaka Hayashi, Yuki Goto, Yutaro Saito, Hiroaki Suga, Jumpei Morimoto, Shinsuke Sando. Oxidation-guided and collision-induced linearization assists de novo sequencing of thioether macrocyclic peptides. Chemical Communications. 2024
Yuchen Zhang, Keisuke Hamada, Masayuki Satake, Toru Sengoku, Yuki Goto, Hiroaki Suga. Switching Prenyl Donor Specificities of Cyanobactin Prenyltransferases. Journal of the American Chemical Society. 2023
Nigel G. J. Richards, Stephen L. Bearne, Yuki Goto, Emily J. Parker. Reactivity and mechanism in chemical and synthetic biology. Philosophical Transactions of the Royal Society B: Biological Sciences. 2023. 378. 1871

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MISC (23)：

菅井佳宣, 江畑一真, 浅水俊平, 後藤佑樹, 菅裕明, 尾仲宏康. 新規labionen構造の形成に関与するlanthipeptide合成酵素の解析. 日本農芸化学会大会講演要旨集(Web). 2018. 2018
尾崎太郎, 尾崎太郎, 菅井佳宣, 浅水俊平, 尾仲宏康, 後藤佑樹, 菅裕明, 池田治生. Dissection of goadsporin biosynthetic machinery by in vitro reconstitution leading to in vivo production of designer analogues. Institute for Fermentation, Osaka. Research Communications. 2018. 32
菅井佳宣, 菅井佳宣, 尾崎太郎, 尾崎太郎, 浅水俊平, 尾仲宏康, 菅裕明, 後藤佑樹. Analysis of lanthipeptide biosynthetic enzymes responsible for formation of novel goadionin structure. Institute for Fermentation, Osaka. Research Communications. 2018. 32
Yuki Goto. [Elaboration of Pseudo-natural Products Using Artificial In Vitro Biosynthesis Systems]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. 2018. 138. 1. 55-61
尾仲宏康, 尾崎太郎, 山下湖奈, 後藤佑樹, 下村杜人, 林昌平, 浅水俊平, 菅井佳宣, 菅裕明. 試験管内完全合成系によるゴードスポリン生合成経路の解析とデザイナーアナログ創製. 日本農芸化学会大会講演要旨集(Web). 2017. 2017

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Education (3)：

2005 - 2008 The University of Tokyo Graduate School of Engineering Department of Advanced Interdisciplinary Studies
2003 - 2005 Kyoto University Graduate School of Engineering Department of Synthetic Chemistry and Biologcal Chemistry
1999 - 2003 Kyoto University Faculty of Engineering School of Industrial Chemistry

Professional career (1)：

Work history (8)：

2024/01 - 現在 Kyoto University Department of Chemistry, Graduate School of Science Professor
2016/10 - 2023/12 東京大学大学院理学系研究科化学専攻准教授
2010/04 - 2016/09 Graduate School of Science, The University of Tokyo Assistant professor
2011/12 - 2015/03 国立研究開発法人科学技術振興機構さきがけ研究「細胞機能の構成的な理解と制御」研究者
2009/10 - 2010/03 Research Center for Advanced Science and Technology, The University of Tokyo Assistant professor

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Awards (9)：

2017/03 - バイオインダストリー協会第1回バイオインダストリー奨励賞
2017/03 - 日本化学会第66回進歩賞
2016/10 - 日本ペプチド学会奨励賞
2014/03 - 日本化学会第94春季年会若い世代の特別講演
2013/11 - 4th Asia-Pacific International Peptide Symposium Excellent Stone Award

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