Rchr
J-GLOBAL ID：201201065505552332   Update date: Feb. 27, 2024

Tatsukawa Hideki

Tatsukawa Hideki
Research field  (4)： Cell biology ,  Applied molecular and cellular biology ,  Molecular biology ,  Pathobiochemistry
Research keywords  (8)： 生化学 ,  分子生物学 ,  農芸化学 ,  生物系薬学 ,  ケミカルバイオロジー.薬理学一般 ,  消化器内科学 ,  腎臓内科学 ,  呼吸器内科学
Research theme for competitive and other funds  (7)：
  • 2023 - 2027 組織硬化を誘導する架橋修飾残基の包括的解明と制御法開発
  • 2019 - 2022 Role of protein cross-linking modifications in regulating epithelial mesenchymal transition in renal tubule
  • 2016 - 2019 Global identification of the substrates of protein crosslinking enzyme and the development of preventive drug in tissue fibrosis
  • 2014 - 2017 Molecular basis fo protein-crosslinking reaction by transglutaminase focusing on aberrant regulation
  • 2014 - 2016 Analysis of mechanism and development of regulation approach in liver fibrosis via transglutaminase
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Papers (66)：
  • Tomohiro Mizuno, Fumihiko Nagano, Yoshimasa Ito, Hideki Tatsukawa, Yoshiki Shinoda, Taishu Takeuchi, Kazuo Takahashi, Naotake Tsuboi, Tadashi Nagamatsu, Shuhei Yamada, et al. Novel function of transglutaminase 2 in extracellular histone-induced acute lung injury. Biochemical and biophysical research communications. 2023. 678. 179-185
  • Hideki Tatsukawa, Ruriko Aoyama, Kiyotaka Hitomi. Development of peptide-based biosensors for detecting cross-linking and deamidation activities of transglutaminases. Amino acids. 2023. 55. 6. 807-819
  • Shunnosuke Kunoki, Hideki Tatsukawa, Yukinao Sakai, Hiroshi Kinashi, Tetsuyoshi Kariya, Yasuhiro Suzuki, Masashi Mizuno, Makoto Yamaguchi, Hiroyuki Sasakura, Masashi Ikeno, et al. Inhibition of Transglutaminase 2 Reduces Peritoneal Injury in a Chlorhexidine-Induced Peritoneal Fibrosis Model. Laboratory investigation; a journal of technical methods and pathology. 2023. 103. 4. 100050-100050
  • Yoshiki Shinoda, Hideki Tatsukawa, Atsushi Yonaga, Ryosuke Wakita, Taishu Takeuchi, Tokuji Tsuji, Miyako Tanaka, Takayoshi Suganami, Kiyotaka Hitomi. Tissue transglutaminase exacerbates renal fibrosis via alternative activation of monocyte-derived macrophages. Cell Death & Disease. 2023. 14. 2. 136-136
  • Teshima H, Endo M, Furuyama Y, Takama H, Tsuji T, Tatsukawa H, Akiyama M, Hitomi K. Involvement of hypoxia inducible factor activity in inevitable air-exposure treatment upon differentiation in a three-dimensional keratinocyte culture. FEBS J. 2023. 290. 8. 2049-2063
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MISC (26)：
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Books (3)：
  • 実験医学別冊 もっとよくわかる!線維化と疾患 : 炎症・慢性疾患の初期からはじまるダイナミックな過程をたどる
    羊土社 2023 ISBN:9784758122139
  • Transglutaminase: Multiple Functional Modifiers and Targets for New Drug Discovery - Preferred Substrate Structure of Transglutaminases
    Springer 2016
  • 肝疾患Review 2010~2011
    日本メディカルセンター出版 2010
Lectures and oral presentations  (66)：
  • Analysis of the mechanism of transglutaminase-mediated tissue fibrosis
    (2020)
  • Characterization of substrates crosslinked by transglutaminase in fibrotic diseases
    (Gordon Research Conference on Transglutaminases in Human Disease Processes 2020)
  • Isozyme-specific identification and characterization of substrates crosslinked by transglutaminases in liver fibrosis
    (The 13th International Symposium on ALPD and Cirrhosis 2018)
  • Isozyme-Specific Global Identification and Analysis of Transglutaminase Substrates in Fibrotic Diseases
    (Gordon Research Conference on Transglutaminases in Human Disease Processes 2018)
  • Global identification and analysis of isozyme-specific substrates crosslinked by transglutaminase in mouse fibrosis model
    (2017)
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Education (3)：
  • 2005 - 2009 Tokyo Medical and Dental University Graduate School of Medical and Dental Sciences Gerontology and Gerodontology
  • 2003 - 2005 Tokyo Medical and Dental University Graduate School of Medical and Dental Sciences Gerontology and Gerodontology
  • 1999 - 2003 Tokyo University of Science Faculty of Science Department of Chemistry
Professional career (3)：
  • 学士(理学) (東京理科大学)
  • 修士(医科学) (東京医科歯科大学)
  • 博士(医学) (東京医科歯科大学)
Work history (6)：
  • 2023/10 - 現在 科学技術振興機構(JST)戦略的創造研究推進事業 さきがけ研究者 兼任
  • 2012/04 - 現在 Nagoya University Graduare School of Pharmaceutical Sciences
  • 2012/03 - 現在 Nagoya University School of Agricultural Sciences
  • 2009/04/01 - 2012/03/31 理化学研究所 特別研究員
  • 2007/04 - 2009/03 理化学研究所 ジュニアリサーチアソシエイト
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Committee career (2)：
  • 2019/06 - 現在 Nature Research Publishing - Scientific reports - Editorial board member
  • 2017/09 - 2019/08 日本生化学会 中部支部 幹事
Awards (6)：
  • 2018/09 - The 13th International Symposium on ALPD and Cirrhosis Young Investigator award
  • 2011/10 - The 6th International Symposium on ALPD and Cirrhosis Travel Award
  • 2010/10 - 中外製薬株式会社&日本肝臓学会 CHUGAI Award 優秀研究賞
  • 2009/10 - 第3回トランスグルタミナーゼ研究会&ポリアミン研究会 合同学術集会 Poster Award
  • 2009/10 - The 4th International Symposium on ALPD and Cirrhosis Best Poster Award & Travel Award
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Association Membership(s) (9)：
日本分子生物学会 ,  日本生化学会 ,  日本農芸化学会 ,  日本腎臓学会 ,  American Thoracic Society ,  日本免疫学会 ,  日本癌学会 ,  日本肝臓学会 ,  ケミカルバイオロジー学会
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