Rchr
J-GLOBAL ID:201201073245425059
Update date: Oct. 01, 2024
Yagishita Sosuke
Yagishita Sosuke
Affiliation and department:
Research field (1):
Neuroscience - general
Research theme for competitive and other funds (7):
- 2023 - 2026 Analyses of the relationship between neuronal activity-dependent protein synthesis and neurofibrillary tangles formation
- 2019 - 2022 The mechanisms of neurofibrillary tangle formation during ageing and the progression of Alzheimer disease
- 2016 - 2019 Mechanisms of memory impairment caused by the increase in phosphorylated tau
- 2014 - 2018 A novel therapeutic strategy for Alzheimer's disease based on the promotion of clearance mechanism of amyloid beta protein
- 2013 - 2017 Readjustment of "amyloid hypothesis" for developing methods to treat Alzheimer disease
- 2011 - 2013 Molecular mechanism of memory impairment in Alzheimer's disease mice model
- 2007 - 2009 ガンマセクレターゼによるアミロイドベータタンパク質の産生機構
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Papers (21):
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Daiki Takewaki, Yuya Kiguchi, Hiroaki Masuoka, Mallahalli S Manu, Ben J E Raveney, Seiko Narushima, Rina Kurokawa, Yusuke Ogata, Yukio Kimura, Noriko Sato, et al. Tyzzerella nexilis strains enriched in mobile genetic elements are involved in progressive multiple sclerosis. Cell reports. 2024. 114785-114785
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Sosuke Yagishita, Megumi Shibata, Akiko Furuno, Shuji Wakatsuki, Toshiyuki Araki. Neuronal Excitation Induces Tau Protein Dephosphorylation via Protein Phosphatase 1 Activation to Promote Its Binding with Stable Microtubules. Neurology International. 2024. 16. 3. 653-662
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Takeru Nagayama, Sosuke Yagishita, Megumi Shibata, Akiko Furuno, Takashi Saito, Takaomi C. Saido, Shuji Wakatsuki, Toshiyuki Araki. Transient sleep apnea results in long-lasting increase in β-amyloid generation and tau hyperphosphorylation. Neuroscience Research. 2024
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Kensuke Iwasa, Sosuke Yagishita, Nan Yagishita-Kyo, Anzu Yamagishi, Shinji Yamamoto, Kota Yamashina, Chikara Haruta, Masashi Asai, Kei Maruyama, Kuniyoshi Shimizu, et al. Long term administration of loquat leaves and their major component, ursolic acid, attenuated endogenous amyloid-β burden and memory impairment. Scientific Reports. 2023. 13. 1
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Nan Yagishita-Kyo, Yuki Ikai, Tomoko Uekita, Akio Shinohara, Chihiro Koshimoto, Keisuke Yoshikawa, Kei Maruyama, Sosuke Yagishita. Testosterone interrupts binding of Neurexin and Neuroligin that are expressed in a highly socialized rodent, Octodon degus. Biochemical and Biophysical Research Communications. 2021. 551. 54-62
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MISC (7):
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栁下聡介. 閉塞性睡眠時無呼吸と認知機能低下. THE LUNG perspectives. 2020. 28. 1
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栁下聡介. 閉塞性睡眠時無呼吸とアルツハイマー病との関係. オベリスク. 2020. 25. 1
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米村洋而, 二井勇人, 柳下聡介, 周防諭, 富田泰輔, 岩坪威, 石浦章一. 酵母再構成系によるγ-セクレターゼにおけるPS1とPS2の比較. 日本分子生物学会年会プログラム・要旨集(Web). 2011. 34th
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Masashi Asai, Sosuke Yagishita, Nobuhisa Iwata, Takaomi Saido, Shoichi Ishiura, Kei Maruyama. The metabolism of APP C-terminal fragments by y-secretase and cathepsin B. JOURNAL OF PHARMACOLOGICAL SCIENCES. 2010. 112. 136P-136P
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Sosuke Yagishita, Masashi Asai, Nobuhisa Iwata, Takaomi Saido, Kei Maruyama, Shoichi Ishiura. Cathepsin 8 inhibitor CA-074Me causes the accumulation of APP C-terminal fragments independently of secretases activities. NEUROSCIENCE RESEARCH. 2009. 65. S64-S64
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Books (2):
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Chapter 7:Co-immunoprecipitation Assay to Investigate the Interaction Strength Between Synaptic Proteins Using COS-7 Cells
2018
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神経変性疾患では細胞内外に異常蛋白質が蓄積する
2018
Lectures and oral presentations (43):
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バンコマイシン投与による腸内細菌叢の攪乱は,脳内の Aβ量を増加させる
(第42回日本認知症学会学術集会 2023)
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微小管との結合に影響を与えるタウのリン酸化部位について
(タウ研究会2023 2023)
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The mechanisms of formation of social novelty by gut microbiota.
(9th Congress for International Human Microbiome Consortium 2022)
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Neuronal activity-dependent alteration of tau phosphorylation.
(2022)
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神経活動に依存したタウのリン酸化変動
(NEURO2022 2022)
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Work history (4):
- 2024/04 - 現在 Kisarazu National College of Technology
- 2016/10 - 2024/03 National Center of Neurology and Psychiatry
- 2012/04 - 2016/09 Saitama Medical University Faculty of Medicine
- 2010/04 - 2012/03 Researcher
Awards (5):
- 2014/10 - 若手優秀発表賞(第131回 日本薬理学会関東部会)
- 2013/06 - 第24回落合記念賞(埼玉医科大学医学部同窓会)
- 2010/03 - 一高賞(東京大学)
- 2009/07 - 若手研究者奨励賞受賞(日本生理学会若手の会)
- 2007/08 - 学会奨励賞(病態と治療におけるプロテアーゼとインヒビター研究会)
Association Membership(s) (4):
Society for Neuroscience
, 日本神経科学学会
, 日本生化学会
, 日本認知症学会
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