Rchr
J-GLOBAL ID:201201075639257251
Update date: Apr. 01, 2024
Ishizu Akihiro
イシヅ アキヒロ | Ishizu Akihiro
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Affiliation and department:
Hokkaido University Faculty of Health Sciences
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Detailed information
Homepage URL (1):
http://kaken.nii.ac.jp/d/r/60321957.ja.html
Research field (1):
Experimental pathology
Research keywords (30):
動物モデル
, 胸腺
, 自己免疫
, T細胞
, IL-6
, トランスクリプトーム
, 血管炎
, 自己反応性T細胞
, 網羅的遺伝子発現解析
, 予後予測
, ATF-1
, シンビスウイルスベクター
, 末梢血
, dominant negative
, 遺伝子治療
, 関節リウマチ
, 血管内皮細胞
, CREB
, 滑膜細胞
, 壊死性血管炎
, トランスクリプトーム解析
, 自己免疫疾患
, HTLV-I
, crm1
, DNAアレイ
, レトロウイルス
, ARF
, ヒト内在性レトロウイルス
, 胸腺腫
, トランスジェニック
Research theme for competitive and other funds (20):
2022 - 2026 Inflammagingにおける炎症・老化細胞の解析とバイオマーカーへの展開
2021 - 2024 Reveal of the pathogenesis of MPO-ANCA-associated vasculitis and development of novel therapeutic strategies
2018 - 2022 Molecular pathology of autoreactive inflammatory T cells
2015 - 2017 Involvement of neutrophil extracellular traps in the development of diabetic angiopathy
2014 - 2017 Basic and clinical strategy to overcome microscopic polyangiitis
2013 - 2016 Dysfunction of proteasome and pathogenesis in age-related disorders
2013 - 2015 Search of the predictive diagnosis marker of the Chlamydia infection, using a pathological experiment.
2012 - 2012 Medium-to-small vessel vasculitis induced by NKT cells that react with vascular endothelial cells
2010 - 2012 Proteasomal dysfunction and pathology
2008 - 2010 Pathogenesis of vasculitis and novel diagnostic and therapeutic strategies
2005 - 2006 The role of thymus in the pathogenesis of necrotizing arteritis
2005 - 2006 MILL分子群による免疫監視機構の解析
2003 - 2004 転写因子CREBを標的とした関節リウマチ制御の基礎的検討
2003 - 2004 EXPRESSION OF HUMAN ENDOGENOUS RETROVIRUS AND ITS POSSIBLE ROLES FOR DEVELOPING AUTOIMMUNE DESIASES
2003 - 2003 動物モデルを用いたHTLV-1発がん機構の解析
2002 - 2003 Development and analyses of novel animal models for human retrovirus-induced desiases.
2002 - 2002 動物モデルを用いたHTLV-I発がん機構の解析
2001 - 2001 モデル動物を用いたHTLV-I発がんおよび関連疾患発症機構の解析
2000 - 2001 Pathogenetic roles of human endogenous retroviruses in autoimmune diseases
2000 - 2000 モデル動物を用いたHTLV-I発がんおよび関連疾患発症機構の解析
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Papers (223):
Yusho Ueda, Daigo Nakazawa, Saori Nishio, Satoka Shiratori-Aso, Takashi Kudo, Atsuko Miyoshi-Harashima, Kanako Watanabe-Kusunoki, Fumihiko Hattanda, Sari Iwasaki, Takahiro Tsuji, et al. Transcription factor Nrf2 activation regulates NETosis, endothelial injury, and kidney disease in myeloperoxidase-positive antineutrophil cytoplasmic antibody-associated vasculitis. Kidney international. 2024
Hodaka Ogawa, Shunichi Yokota, Yumeka Hosoi, Ayano Shindo, Naho Ogawa, Ryodai Yamamura, Tomohiro Shimizu, Issei Nakade, Suishin Arai, Mai Taniguchi, et al. Methylprednisolone pulse-enhanced neutrophil extracellular trap formation in mice with imiquimod-induced lupus-like disease, resulting in ischaemia of the femoral head cartilage. Lupus science & medicine. 2023. 10. 2
Issei Nakade, Yuto Tamura, Fuyu Hashimoto, Yuko Ariza, Shingo Hotta, Hirofumi Fujigaya, Suishin Arai, Mai Taniguchi, Hodaka Ogawa, Yuka Nishibata, et al. Bruton's tyrosine kinase is a possible therapeutic target in microscopic polyangiitis. Arthritis research & therapy. 2023. 25. 1. 215-215
Masayuki Sato, Yuka Nishibata, Sakiko Masuda, Tsunehisa Nagamori, Emi Ishibazawa, Yoichiro Yoshida, Hironori Takahashi, Akihiro Ishizu, Satoru Takahashi. Demonstration of equivocal anti-glomerular basement membrane antibody positivity as a non-specific reaction through multiple immunologic assays in a case of pediatric asymptomatic hematuria. Clinical Biochemistry. 2023. 120. 110650-110650
Daigo Nakazawa, Yohei Takeda, Masatoshi Kanda, Utano Tomaru, Haruko Ogawa, Takashi Kudo, Satoka Shiratori-Aso, Kanako Watanabe-Kusunoki, Yusho Ueda, Atsuko Miyoshi, et al. Inhibition of Toll-like receptor 4 and Interleukin-1 receptor prevent SARS-CoV-2 mediated kidney injury. Cell death discovery. 2023. 9. 1. 293-293
more...
MISC (466):
川上民裕, 中出一生, 田村宥人, 伊藤吹夕, 西端友香, 益田紗季子, 外丸詩野, 石津明洋. 皮膚血管炎動物モデルの完成. 脈管学(Web). 2023. 63. 1
川上民裕, 中出一生, 田村宥人, 西端友香, 益田紗季子, 石津明洋, 伊藤吹夕, 外丸詩野. 正常ラットに抗PSPT抗体と抗LAMP2抗体の静脈注射により皮膚血管炎の発症に成功した. 日本皮膚科学会雑誌. 2023. 133. 3
川上民裕, 有村義宏, 池田高治, 石黒直子, 石津明洋, 伊藤吹夕, 猪原登志子, 沖山奈緒子, 小野さち子, 要伸也, et al. 皮膚血管炎・血管障害診療ガイドライン2023-IgA 血管炎,クリオグロブリン血症性血管炎,結節性多発動脈炎,リベド様血管症の治療の手引き 2023-. 日本皮膚科学会雑誌. 2023. 133. 9
宮崎龍彦, 小林一博, 新居俊典, 酒々井夏子, 石津明洋, 武曾理恵, 小川弥生, 中沢大悟, 黒川真奈絵. OMAAVの上気道生検組織の病理学的特徴. 脈管学(Web). 2021. 61. 1
新海隼人, 加藤千恵次, 川上民裕, 高橋啓, 西端友香, 益田紗季子, 田中敏, 外丸詩野, 石津明洋. 人工知能による結節性多発動脈炎と皮膚動脈炎の皮膚生検画像の鑑別. 脈管学(Web). 2021. 61. 1
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Patents (1):
自己免疫疾患の被験者に対する治療効果の予測方法
Professional career (1):
博士(医学) (北海道大学)
Work history (1):
2012 - Hokkaido University
Awards (2):
2009/11 - 日本病理学会 学術研究賞
2005/04 - 日本病理学会 学術奨励賞
Association Membership(s) (5):
THE JAPANESE CANCER ASSOCIATION
, THE JAPANESE SOCIETY OF CLINICAL CYTOLOGY
, JAPANESE SOCIETY FOR IMMUNOLOGY (JSI)
, JAPAN COLLEGE OF RHEUMATOLOGY
, THE JAPANESE SOCIETY OF PATHOLOGY
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