Kakuda Nobuto

カクダノブト | Kakuda Nobuto

Affiliation and department：

Research field (1)： Neuropathology

Research keywords (6)：アミロイドβタンパク , γ-セクレターゼ , アルツハイマー病 , Amyloid beta protein , gamma-secretase , Alzheimer's disease

Research theme for competitive and other funds (5)：

2023 - 2026 動脈硬化症の連鎖的破綻によるアルツハイマー病の発症機序解明
2017 - 2020 Detecting early-stage biomarker of multiple sclerosis using Imaging Mass Spectrometry
2016 - 2019 Efficacy of TSPAN for gamma-secretase activity
2015 - 2016 TSPAN6によるγ-secretase活性変化の機序解明
2004 - 2004 アルツハイマー病におけるガンマセクレターゼの機能解析

Papers (20)：

Masaya Ikegawa, Nobuto Kakuda, Tomohiro Miyasaka, Yumiko Toyama, Takashi Nirasawa, Karolina Minta, Jörg Hanrieder. Mass spectrometry imaging in Alzheimer's disease. Brain connectivity. 2023
Rikuya Yoshimura, Tomohiro Miyasaka, Satoru Funamoto, Takashi Saito, Takaomi C Saido, Masaya Ikegawa, Nobuto Kakuda. The senile plaque: Morphological differences in APP knock-in mice brains by fixatives. Brain and behavior. 2023. e2953
Nobuto Kakuda, Mako Takami, Masayasu Okochi, Kensaku Kasuga, Yasuo Ihara, Takeshi Ikeuchi. Switched Aβ43 generation in familial Alzheimer’s disease with presenilin 1 mutation. Translational Psychiatry. 2021. 11. 1. 558-558
Ayaka Hagita, Satoko Wada-Kakuda, Mika Nobuhara, Nobuto Kakuda, Tomohiro Miyasaka. Quantitative fractionation of tissue microtubules with distinct biochemical properties reflecting their stability and lability. Biochemical and biophysical research communications. 2021. 560. 186-191
Alam Shahnur, Masaki Nakano, Seiko Ishihara, Nobuto Kakuda, Tomohiro Miyasaka, Hina Uchiyama, Yuuna Shirai, Mohammad Moniruzzaman, Takashi Saito, Takaomi C Saido, et al. A potential defense mechanism against amyloid deposition in cerebellum. Biochemical and biophysical research communications. 2021. 535. 25-32

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MISC (42)：

外山友美子, 朴洪宣, 角田伸人, 韮澤崇, 村山繁雄, 貫名信行, 池川雅哉. イメージング質量分析法を用いたアルツハイマー病をはじめとする脳病理解析. 組織細胞化学. 2022. 2022
外山友美子, 徳平壮一郎, 朴洪宣, 韮澤崇, 角田伸人, 宮坂知宏, 村山繁雄, 齊藤祐子, 内藤康秀, 貫名信行, et al. イメージング質量分析法を用いたアルツハイマー病脳の組織マルチオミクス解析. Dementia Japan. 2021. 35. 4
徳平壮一郎, 外山友美子, 大村孝幸, 小谷政弘, 田代晃, 角田伸人, 韮澤崇, 村山繁雄, 内藤康秀, 池川雅哉. Development of a small molecule mass spectrometry imaging method with DIUTHAME for Alzheimer’s disease and brain amyloid angiopathy brain. JSBMS Letters. 2021. 46. Supplement
外山友美子, 武笠結天, 新谷祈, 徳平壮一郎, 大村孝幸, 小谷政弘, 田代晃, 角田伸人, 韮澤崇, 村山繁雄, et al. DIUTHAMEを用いたアルツハイマー病(AD)脳の迅速MALDI質量分析イメージング(Rapid MALDI mass spectrometry imaging for Alzheimer's disease(AD) brain using DIUTHAME). JSBMS Letters. 2020. 45. Suppl. 66-66
安井悠生, 亀山大樹, 山本康太, 韮澤崇, 梶田遼, 角田伸人, 平田岳史, 池川雅哉. Visualization of mouse brain proteome for the study of lithium neuropharmacology with MALDI-Imaging Mass Spectroscopy. JSBMS Letters. 2020. 45. Supplement

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Education (8)：

- 2005 The University of Tokyo
- 2005 The University of Tokyo Graduate School, Division of Medical Sciences
- 2001 Tokyo Institute of Technology Bioscience and Biotechnology Biological Information
- 2001 Tokyo Institute of Technology Graduate School, Division of Life Science and Engineering
- 1999 Tokyo Institute of Technology School of Bioscience and Biotechnology

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Professional career (1)：

Work history (4)：

2015/04 - 現在 Doshisha University Faculty of Life and Medical Sciences Department of Medical Life Systems
2013/09 - 2015/03 KU Leuven Postdoctral fellow
2011/04 - 2013/08 Doshisha University Organization for Research Initiatives and Development Researcher
2005/04 - 2011/03 株式会社免疫生物研究所

Association Membership(s) (1)：

日本認知症学会

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