Abe Kazuhiro

アベカズヒロ | Abe Kazuhiro

Affiliation and department：
Job title： Professor
Homepage URL (1)： http://www.cespi.nagoya-u.ac.jp/index.html

Research field (2)： Structural biochemistry , Functional biochemistry

Research keywords (10)： Cation pump , Apoptosis , X-ray crystallography , Active transporters , Flippase , P-type ATPase , Proton pump , Gastric , Cryo-EM , membrane proteins

Research theme for competitive and other funds (15)：

2021 - 2024 物質不均衡分布を司る能動輸送体P型ATPaseの構造機能生理学
2017 - 2022 クライオ電子顕微鏡のフィードバックに基づく膜タンパク質複合体の生産と技術支援
2019 - 2021 胃プロトンポンプを初めとしたヒト能動輸送体の構造機能解析と創薬への展開
2019 - 2021 物質不均衡を司る能動輸送体の構造解析と創薬
2018 - 2021 胃酸分泌の分子メカニズム解明と新規薬剤開発の為の構造基盤

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Papers (56)：

Pablo Artigas, Dylan J Meyer, Victoria C Young, Kerri Spontarelli, Jessica Eastman, Evan Strandquist, Huan Rui, Benoît Roux, Matthew A Birk, Hanayo Nakanishi, et al. A Na pump with reduced stoichiometry is up-regulated by brine shrimp in extreme salinities. Proceedings of the National Academy of Sciences of the United States of America. 2023. 120. 52. e2313999120
Kazuhiro Abe, Mami Ozako, Miki Inukai, Yoe Matsuyuki, Shinnosuke Kitayama, Chisato Kanai, Chiaki Nagai, Chai C. Gopalasingam, Christoph Gerle, Hideki Shigematsu, et al. Deep learning driven de novo drug design based on gastric proton pump structures. Communications Biology. 2023. 6. 1
Victoria C. Young, Hanayo Nakanishi, Dylan J. Meyer, Tomohiro Nishizawa, Atsunori Oshima, Pablo Artigas, Kazuhiro Abe. Structure and function of H+/K+ pump mutants reveal Na+/K+ pump mechanisms. Nature Communications. 2022. 13. 1
Saki Tanaka, Mikio Morita, Tatsuya Yamagishi, Hridya Valia Madapally, Kenichi Hayashida, Himanshu Khandelia, Christoph Gerle, Hideki Shigematsu, Atsunori Oshima, Kazuhiro Abe. Structural Basis for Binding of Potassium-Competitive Acid Blockers to the Gastric Proton Pump. Journal of medicinal chemistry. 2022. 65. 11. 7843-7853
Hanayo Nakanishi, Kenichi Hayashida, Tomohiro Nishizawa, Atsunori Oshima, Kazuhiro Abe. Cryo-EM of the ATP11C flippase reconstituted in Nanodiscs shows a distended phospholipid bilayer inner membrane around transmembrane helix 2. The Journal of biological chemistry. 2022. 298. 1. 101498-101498

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MISC (35)：

中西華代, 西澤知宏, 瀬川勝盛, 濡木理, 藤吉好則, 長田重一, 阿部一啓, 阿部一啓. Crystal and cryo-EM structures of phospholipid flippase ATP11C, a ”Death Pump”. 日本生体エネルギー研究会討論会講演要旨集. 2020. 46th
山本健太, 入江克雅, 藤吉好則, 阿部一啓, 山本健太, 入江克雅, 藤吉好則, 阿部一啓. Structural determinants for the K⁺-binding stoichiometry in the E2P state of gastric H⁺,K⁺-ATPase. 日本生体エネルギー研究会討論会講演要旨集. 2019. 45th
Dubey Vikas, Han Minwoo, Kopec Wojciech, Solov'yov Ilia A, Abe Kazuhiro, Khandelia Himanshu. K+ binding and proton redistribution in the E2P state of the H+, K+-ATPase. SCIENTIFIC REPORTS. 2018. 8
Kazuhiro Abe, Katsumasa Irie, Hanayo Nakanishi, Hiroshi Suzuki, Yoshinori Fujiyoshi. Crystal structures of the gastric proton pump. Nature. 2018. 556. 7700. 214-218
Dubey Vikas, Abe Kazuhiro, Solov'yov Ilia, Khandelia Himanshu. The Elusive Proton in the Gastric Proton Potassium ATPase. BIOPHYSICAL JOURNAL. 2018. 114. 3. 146A-146A

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Books (2)：

Methods in Molecular Biology, P-type ATPases, 39 Two-dimensional crystallization of gastric H+,K+-ATPase for structural analysis by electron crystallography
Springer 2016 ISBN:9781493931781
Methods in Molecular Biology, P-type ATPases, 4 Isoration of H+,K+-ATPase-enriched membrane fraction from pig stomach
Springer 2016 ISBN:9781493931781

Lectures and oral presentations (60)：

Crystal structures of the gastric proton pump - molecular basis for the binding of acid suppressants, H+-extrusion and K+-counter-transport
(2020)
Structural basis of the proton extrusion mechanism of the gastric proton pump
(2020)
Molecular mechanisms for the drug binding, H+-extrusion and the K+ counter-transport
(Academia Sinica IBC seminar 2019)
Crystal structure of the gastric proton pump
(World Laureates Forum 2nd conference 2019)
X線結晶学とクライオ電顕で得られた構造情報の上手な活用法 ~胃プロトンポンプの構造解析を例として~
(2019年度生理研研究会 2019)

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Education (3)：

2001 - 2004 Hokkaido University Graduate School, Division of Natural Science
1999 - 2001 Hokkaido University Graduate School, Division of Natural Science
1995 - 1999 Hokkaido University Faculty of Science

Professional career (1)：

博士(理学) (北海道大学)

Work history (9)：

2024/04 - 現在 Hokkaido University Faculty of Science Department of Chemistry Professor
2016/01/01 - 2024/04 Nagoya University Cellular and Structural Physiology Institute Division Associate professor
2012/04/01 - 現在 Nagoya University Graduate School of Pharmaceutical Sciences Department of Basic Medicinal Sciences Structural Biology
2012/04/01 - 2015/12/31 Nagoya University Cellular and Structural Physiology Institute Division Assistant Professor
2011/04/01 - 2012/03/31 京都大学特定研究員

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Awards (5)：

2013/09/11 - 日本生化学会日本生化学会奨励賞
2011/12 - 生体エネルギー研究会若手奨励賞
2011/10 - ASBMB JBC Herbert Tabor Award
2008/08/09 - P-ATPase conference Margrethe Moller Award
2004/08 - FASEB FASEB SRC Young Scientist Award

Association Membership(s) (2)：

The Biophysical Society of Japan , 日本生化学会

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