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J-GLOBAL ID：201201078597497949   Update date: Nov. 20, 2024

Abe Kazuhiro

アベ カズヒロ | Abe Kazuhiro
Affiliation and department：
Hokkaido University Faculty of Science Department of Chemistry

About Hokkaido University Faculty of Science Department of Chemistry


Job title： Professor
Homepage URL  (1)： http://www.cespi.nagoya-u.ac.jp/index.html
Research field  (2)： Structural biochemistry ,  Functional biochemistry
Research keywords  (10)： Cation pump ,  Apoptosis ,  X-ray crystallography ,  Active transporters ,  Flippase ,  P-type ATPase ,  Proton pump ,  Gastric ,  Cryo-EM ,  membrane proteins
Research theme for competitive and other funds  (15)：
  • 2021 - 2024 物質不均衡分布を司る能動輸送体P型ATPaseの構造機能生理学
  • 2017 - 2022 クライオ電子顕微鏡のフィードバックに基づく膜タンパク質複合体の生産と技術支援
  • 2019 - 2021 胃プロトンポンプを初めとしたヒト能動輸送体の構造機能解析と創薬への展開
  • 2019 - 2021 物質不均衡を司る能動輸送体の構造解析と創薬
  • 2018 - 2021 胃酸分泌の分子メカニズム解明と新規薬剤開発の為の構造基盤
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Papers (59)：
  • Kazuhiro Abe, Jeff McDermott, Hridya Valia Madapally, Parthiban Marimuthu, Chai C. Gopalasingam, Christoph Gerle, Hideki Shigematsu, Himanshu Khandelia, Gustavo Blanco. Molecular Structure of the Na+,K+-ATPase α4β1 Isoform in Its Ouabain-Bound Conformation. International Journal of Molecular Sciences. 2024
  • Christoph Gerle, Chimari Jiko, Atsuki Nakano, Ken Yokoyama, Chai C. Gopalasingam, Hideki Shigematsu, Kazuhiro Abe. Human F-ATP synthase as a drug target. Pharmacological Research. 2024. 209. 107423-107423
  • Hridya Valia Madapally, Kazuhiro Abe, Vikas Dubey, Himanshu Khandelia. Specific protonation of acidic residues confers K+ selectivity to the gastric proton pump. Journal of Biological Chemistry. 2024. 300. 1. 105542-105542
  • Pablo Artigas, Dylan J Meyer, Victoria C Young, Kerri Spontarelli, Jessica Eastman, Evan Strandquist, Huan Rui, Benoît Roux, Matthew A Birk, Hanayo Nakanishi, et al. A Na pump with reduced stoichiometry is up-regulated by brine shrimp in extreme salinities. Proceedings of the National Academy of Sciences of the United States of America. 2023. 120. 52. e2313999120
  • Kazuhiro Abe, Mami Ozako, Miki Inukai, Yoe Matsuyuki, Shinnosuke Kitayama, Chisato Kanai, Chiaki Nagai, Chai C. Gopalasingam, Christoph Gerle, Hideki Shigematsu, et al. Deep learning driven de novo drug design based on gastric proton pump structures. Communications Biology. 2023. 6. 1
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MISC (35)：
  • 中西華代, 西澤知宏, 瀬川勝盛, 濡木理, 藤吉好則, 長田重一, 阿部一啓, 阿部一啓. Crystal and cryo-EM structures of phospholipid flippase ATP11C, a ”Death Pump”. 日本生体エネルギー研究会討論会講演要旨集. 2020. 46th
  • 山本健太, 入江克雅, 藤吉好則, 阿部一啓, 山本健太, 入江克雅, 藤吉好則, 阿部一啓. Structural determinants for the K+-binding stoichiometry in the E2P state of gastric H+,K+-ATPase. 日本生体エネルギー研究会討論会講演要旨集. 2019. 45th
  • Dubey Vikas, Han Minwoo, Kopec Wojciech, Solov'yov Ilia A, Abe Kazuhiro, Khandelia Himanshu. K+ binding and proton redistribution in the E2P state of the H+, K+-ATPase. SCIENTIFIC REPORTS. 2018. 8
  • Kazuhiro Abe, Katsumasa Irie, Hanayo Nakanishi, Hiroshi Suzuki, Yoshinori Fujiyoshi. Crystal structures of the gastric proton pump. Nature. 2018. 556. 7700. 214-218
  • Dubey Vikas, Abe Kazuhiro, Solov'yov Ilia, Khandelia Himanshu. The Elusive Proton in the Gastric Proton Potassium ATPase. BIOPHYSICAL JOURNAL. 2018. 114. 3. 146A-146A
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Books (2)：
  • Methods in Molecular Biology, P-type ATPases, 39 Two-dimensional crystallization of gastric H+,K+-ATPase for structural analysis by electron crystallography
    Springer 2016 ISBN:9781493931781
  • Methods in Molecular Biology, P-type ATPases, 4 Isoration of H+,K+-ATPase-enriched membrane fraction from pig stomach
    Springer 2016 ISBN:9781493931781
Lectures and oral presentations  (71)：
  • 細胞膜脂質フリッパーゼATP11Cの構造生理学
    (第45回生体膜と薬物の相互作用 シンポジウム 2024)
  • Structural physiology of P-type ATPases that generate asymmetric distributions of cations and phospholipids
    ("Biased assembly" in Neuroscience and Cell Biology 2024)
  • 能動輸送体 P-type ATPase の構造生理学
    (2024年度生理研研究会「生理機能の理解に向けた膜タンパク質機能ダイナミクス研究の最前線と未来開拓」 2024)
  • Structural physiology of gastric proton pump and related cation pumps
    (The 15th CSE International Summer School & The 12th ALP International Symposium 2024)
  • 能動輸送体 P-type ATPaseの分子生命化学
    (2024)
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Education (3)：
  • 2001 - 2004 Hokkaido University Graduate School, Division of Natural Science
  • 1999 - 2001 Hokkaido University Graduate School, Division of Natural Science
  • 1995 - 1999 Hokkaido University Faculty of Science
Professional career (1)：
  • 博士(理学) (北海道大学)
Work history (9)：
  • 2024/04 - 現在 Hokkaido University Faculty of Science Department of Chemistry Professor
  • 2016/01/01 - 2024/04 Nagoya University Cellular and Structural Physiology Institute Division Associate professor
  • 2012/04/01 - 現在 Nagoya University Graduate School of Pharmaceutical Sciences Department of Basic Medicinal Sciences Structural Biology
  • 2012/04/01 - 2015/12/31 Nagoya University Cellular and Structural Physiology Institute Division Assistant Professor
  • 2011/04/01 - 2012/03/31 京都大学 特定研究員
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Awards (5)：
  • 2013/09/11 - 日本生化学会 日本生化学会奨励賞
  • 2011/12 - 生体エネルギー研究会 若手奨励賞
  • 2011/10 - ASBMB JBC Herbert Tabor Award
  • 2008/08/09 - P-ATPase conference Margrethe Moller Award
  • 2004/08 - FASEB FASEB SRC Young Scientist Award
Association Membership(s) (2)：
The Biophysical Society of Japan ,  日本生化学会
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