Nishihara Shoko

ニシハラショウコ | Nishihara Shoko

Affiliation and department：
Job title： Professor
Other affiliations (2)：

Soka University Graduate School of Science and Engineering, Department of Biosciences Professor
Soka University Faculty of Science and Engineering, Department of Science and Engineering for Sustainable Innovation Professor

Homepage URL (2)： https://www.soka.ac.jp/faculty-profiles/shoko-nishihara/ , https://www.soka.ac.jp/en/faculty-profiles/shoko-nishihara/#anchor1

Research field (5)： Structural biochemistry , Functional biochemistry , Molecular biology , Biological, health, and medical informatics , Developmental biology

Research keywords (23)：糖鎖生物学 , 多能性幹細胞 , ES細胞 , Rare disease , 糖転移酵素 , Gene polymorphism , 組織幹細胞 , ショウジョウバエ , 糖鎖 , プロテオグライカン , 発生・分化 , 硫酸化 , PAPS輸送体 , ノックアウトマウス , RNAi , ゴルジ装置 , フコース転移酵素 , 蛋白質 , 生理機能 , ルイス抗原 , 分子生物学 , 分子遺伝学 , 神経分化

Research theme for competitive and other funds (12)：

2022 - 2025 Functional analysis of O-GlcNAc modification that regulates the liquid-liquid phase separation in pluripotent stem cells.
2018 - 2021 シグナル受容体の不均一な細胞膜局在が決めるES細胞の新規分化方向決定機構の解明
2016 - 2018 成熟血球細胞の糖鎖関連分子が担う「造血幹細胞へのフィードバック制御」の探索と解明
2016 - 2017 ES/iPS細胞のナイーブ状態を決める糖鎖と再生医療への応用 -糖鎖の網羅的探索と新規培養法の開発 -
2015 - 2017 ヒトES/iPS細胞の維持と分化におけるプラズマ照射効果と分子生物学的基盤の形成

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Papers (177)：

Hideo Hagihara, Hirotaka Shoji, Satoko Hattori, Giovanni Sala, Yoshihiro Takamiya, Mika Tanaka, Masafumi Ihara, Mihiro Shibutani, Izuho Hatada, Kei Hori, et al. Large-scale animal model study uncovers altered brain pH and lactate levels as a transdiagnostic endophenotype of neuropsychiatric disorders involving cognitive impairment. eLife. 2024. 12
Yusuke Matsui, Akira Togayachi, Kazuma Sakamoto, Kiyohiko Angata, Kenji Kadomatsu, Shoko Nishihara. Single-cell Glycogenomics Deciphers Links Between Altered Transcriptional Regulation and Aberrant Glycosylation in Alzheimer's Disease. bioRxiv : the preprint server for biology. 2023
Nishihara S, Nakayama KI. Assay of nucleotide sugar transport activity (Golgi/ER transporter). 2023
Nishihara S. Assay of 3'-phosphoadenosine 5'-phosphosulfate (PAPS) transport activity. 2023
Eriko Aoki, Noriyoshi Manabe, Shiho Ohno, Taiga Aoki, Jun-Ichi Furukawa, Akira Togayachi, Kiyoko Aoki-Kinoshita, Jin-Ichi Inokuchi, Kenji Kurosawa, Tadashi Kaname, et al. Predicting the pathogenicity of missense variants based on protein instability to support diagnosis of patients with novel variants of ARSL. Molecular Genetics and Metabolism Reports. 2023. 37. 101016-101016

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MISC (120)：

青木英莉子, 真鍋法義, 大野詩歩, 青木大芽, 古川潤一, 栂谷内晶, 木下聖子, 井ノ口仁一, 黒澤健司, 要匡, et al. A new method for diagnosis and predicting X-linked recessive brachytelephalangic chondrodysplasia punctata: Computational analysis and identification of novel missense mutation. 日本分子生物学会年会プログラム・要旨集(Web). 2022. 45th
要匡, 太田隼人, 柳久美子, 花松久寿, PECORI Federico, 古川潤一, 山口芳樹, 上原朋子, 井ノ口仁一, 木下聖子, et al. Genes to diagnosis and therapy in glycogenomics disorders: The example of GDP-fucose transporter deficiency, a rare disease. 日本分子生物学会年会プログラム・要旨集(Web). 2022. 45th
西原祥子, 木下聖子, 栂谷内晶, 細田正恵, 伊藤和義, 山口芳樹, 真鍋法義, 大野詩歩, 稲森啓一郎, 井ノ口仁一, et al. Comprehensive extraction and analysis of the whole human glycan-related gene variant. 日本糖質学会年会要旨集. 2021. 40th
高瀬明, 高瀬明, 一宮智美, 岡松正敏, 木下貴明, 木下貴明, 小林大樹, 市居修, 市居修, 山本直樹, et al. Human H1N1 influenza A viruses utilize sulfated glycans containing α2,3-linked sialic acid expressed on the membranes of chicken embryos as receptors. 日本ウイルス学会学術集会プログラム・予稿集(Web). 2021. 68th
小林大樹, 市居修, 日尾野隆大, 西原祥子, 高瀬明, 磯田典和, 磯田典和, 迫田義博, 迫田義博. シチメンチョウの気管上皮に発現する多様な鳥インフルエンザウイルスレセプターの構造解析. 日本獣医学会学術集会講演要旨集. 2021. 164th (CD-ROM)

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Books (22)：

Comprehensive Glycoscience 2nd edition vol. 5
Elsevier 2021 ISBN:9780128194751
Glycoscience: Basic Science to Applications -Insights from the Japan Consortium for Glycobiology and Glycotechnology
Springer 2019 ISBN:9789811358555
未来を創るグライコサイエンス-我が国のロードマップ-
日本糖鎖コンソーシアム 2018
Molecular dissection of biological effects for mouse embryonic stem cells differentiation treated by low-temperature atmospheric-pressure plasma (APP).
Academic Press 2018
ショウジョウバエが解き明かす、糖鎖による、発生とシグナル伝達の制御. 糖鎖の新機能開発・応用ハンドブック. 秋吉一成監修
エヌ・ティー・エス 2015

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Lectures and oral presentations (191)：

O-GlcNAcylation regulates stem cell pluripotency through p-body formation
(The 26th International Glycoconjugate Symposium (Glyco26) 2023)
Glycosylation regulates pluripotent stem cell status and signaling
(Glycobiology Gordon Research Conference, Ventura, United States 2023)
Genes to diagnosis and therapy in glycogenomics disorders:ヒト糖鎖関連希少疾患GDP-フコース輸送体欠損症を例として
(第45回日本分子生物学会年会 2022)
X連鎖性劣性末節骨短縮型点状軟骨異形成症の予測と診断:コンピューター解析と新規ミスセンス変異の同定
(第45回日本分子生物学会年会 2022)
ルマタン硫酸はマウス胚性幹細胞の自己複製能に必要である
(第95回日本生化学会大会 2022)

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Education (3)：

1977 - 1982 The University of Tokyo Graduate School of Science Department of Chemistry
1975 - 1977 The University of Tokyo Facluty of Sicence Department of Chemistry
1973 - 1975 The University of Tokyo

Professional career (1)：

Doctor of Science (The University of Tokyo)

Work history (16)：

2021/01 - 現在 Soka University Glycan & Life System Integration Center (GaLSIC) Director
2020/04 - 現在 Soka University Graduate School of Science and Engineering, Department of Biosciences Professor
2015/04 - 現在 Soka University Faculty of Science and Engineering, Department of Science and Engineering for Sustainable Innovation Professor
2020/04 - 2021/03 Soka University Graduate School of Science and Engineering, Department of Biosciences Dean
2019/04 - 2020/12 Soka University Glycan & Life System Integration Center (GaLSIC) Director

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Committee career (27)：

2019/04 - 現在 Mizutani Foundation for Glycoscience Councilor
2017/04 - 現在 The Japan Science Society Councilor
2016/04 - 現在 Glyconjugate Journal Editorial Board Member
2013/01 - 現在 The Japan Consortium for Glycobiology and Glycotechnology Vice President
2013/01 - 現在 Japan Consortium for Glycobiology and Glycotechnology Director

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Association Membership(s) (11)：

Chemical Society of Japan , Japanese Cancer Association , Japanese Society for Regenerative Medicine , JAPANESE SOCIETY OF CARBOHYDRATE RESEARCH , MOLECULAR BIOLOGY SOCIETY OF JAPAN , JAPANESE BIOCHEMICAL SOCIETY , International Society for Stem Cell Research , American Society for Biochemistry and Molecular Biology , Society for Glycobiology , Forum: Carbohydrates Coming of Age , Japan Consortium for Glycobiology and Glycotechnology

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