Rchr
J-GLOBAL ID:201201084500571295   Update date: Jan. 31, 2024

Hirota Kouji

ヒロタ コウジ | Hirota Kouji
Affiliation and department:
Homepage URL  (1): https://khirota9.wixsite.com/website
Research field  (3): Genetics ,  Molecular biology ,  Cell biology
Research keywords  (30): 組換え ,  ヒストン修飾 ,  DT40 ,  相同組換え ,  ノンコーディングRNA ,  Exo1 ,  DT40細胞 ,  Blm ,  組換え促進法 ,  細胞分化 ,  イムノグロブリン ,  トリBリンパ球 ,  標的組換え ,  クロマチン再編成 ,  transcriptome ,  クロマチン ,  染色体 ,  減数分裂 ,  転写制御 ,  DNA複製 ,  ストレス応答 ,  ヒストンアセチル化 ,  バイオテクノロジー ,  癌 ,  セントロメア ,  ゲノム ,  non-coding RNA ,  SPO11 ,  Bloom症候群 ,  姉妹染色体結合
Research theme for competitive and other funds  (20):
  • 2022 - 2025 相同的組換えでの相同並行三重鎖DNAの働き
  • 2019 - 2024 International collaborations for revealing the synergistic genetic relationship in genome maintenance systems
  • 2021 - 2023 Search for a pioneer polymerase complex that opens chromatin in non-coding RNA transcribed regions
  • 2020 - 2023 Role of proofreading exonuclease activity of replicative polymerase epsilon in replication fork slowing at DNA damage
  • 2016 - 2021 Establishment of Novel Bioassays for in vivo Genotoxicity Prediction and Mechanism Characterization
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Papers (97):
  • Tasnim Ahmad, Ryotaro Kawasumi, Tomoya Taniguchi, Takuya Abe, Kazuhiro Terada, Masataka Tsuda, Naoto Shimizu, Toshiki Tsurimoto, Shunichi Takeda, Kouji Hirota. The proofreading exonuclease of leading-strand DNA polymerase epsilon prevents replication fork collapse at broken template strands. Nucleic Acids Research. 2023
  • Ivan Psakhye, Ryotaro Kawasumi, Takuya Abe, Kouji Hirota, Dana Branzei. PCNA recruits cohesin loader Scc2 to ensure sister chromatid cohesion. Nature structural & molecular biology. 2023
  • Mubasshir Washif, Tasnim Ahmad, Md Bayejid Hosen, Md Ratul Rahman, Tomoya Taniguchi, Hiromori Okubo, Kouji Hirota, Ryotaro Kawasumi. CTF18-RFC contributes to cellular tolerance against chain-terminating nucleoside analogs (CTNAs) in cooperation with proofreading exonuclease activity of DNA polymerase ε. DNA repair. 2023. 127. 103503-103503
  • Daiki Ikemoto, Tomoya Taniguchi, Kouji Hirota, Kiyoshi Nishikawa, Kan Okubo, Takuya Abe. Application of neural network-based image analysis to detect sister chromatid cohesion defects. Scientific Reports. 2023. 13. 1
  • Toshiaki Nakano, Takahito Moriwaki, Masataka Tsuda, Misa Miyakawa, Yuto Hanaichi, Hiroyuki Sasanuma, Kouji Hirota, Masanobu Kawanishi, Hiroshi Ide, Keizo Tano, et al. SPRTN and TDP1/TDP2 Independently Suppress 5-Aza-2′-deoxycytidine-Induced Genomic Instability in Human TK6 Cell Line. Chemical Research in Toxicology. 2022. 35. 11. 2059-2067
more...
MISC (19):
Education (3):
  • 1998 - 2001 The University of Tokyo Graduate School of Science Department of Biophysics and Biochemistry
  • 1996 - 1998 The University of Tokyo Graduate School of Science Department of Biophysics and Biochemistry
  • 1992 - 1996 The University of Tokyo Faculty of Science Department of Biophysics and Biochemistry
Professional career (1):
  • 博士(理学) (東京大学大学院理学系研究科生物化学専攻)
Work history (5):
  • 2012/04 - 現在 Tokyo Metropolitan University Graduate School of Science, Graduate School of Science
  • 2010/05 - 2012/03 京都大学 医学(系)研究科(研究院) 准教授
  • 2008/04 - 2010/04 京都大学 医学(系)研究科(研究院) 助教
  • 2005/04 - 2008/03 理化学研究員 基礎科学特別研究員
  • 2001/04 - 2005/03 理化学研究所 協力研究員
Association Membership(s) (3):
THE JAPANESE ENVIRONMENTAL MUTAGEN SOCIETY ,  THE JAPANESE CANCER ASSOCIATION ,  THE MOLECULAR BIOLOGY SOCIETY OF JAPAN
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