Research field (2)：
Nervous system function
, Psychiatry
Research keywords (10)：
Large scale two photon imaging
, Autism spectrum disorder
, Frontal association cortex
, chemogenetic manipulation
, Optogenetic manipulation
, Thalamus
, cerebellum
, Schizophrenia
, Neuropixels recordings
, Purkinje cell
Research theme for competitive and other funds (8)：
2024 - 2027 精神疾患の認知障害に関わる視床-前頭野投射の解明
2022 - 2024 Elucidation of the role of the thalamo-prefrontal projections for cognitive dysfunction in psychiatric disorders
2021 - 2024 Holism in neuroscience: Large-scale recording and simulation
2021 - 2024 Large scale dual-axis two-photon imaging of the cerebro-cerebellar interactions to disentangle the mechanisms of the disruption of holism in psychiatric disorders
2021 - 2023 Neural circuit basis of prefrontal-cerebellar loop in timing prediction
2020 - 2022 Role of the cerebellar circuit deficits in the pathological basis for autism spectrum disorder
2020 - 2021 精神神経疾患の発症に関わる小脳神経回路基盤
2017 - 2019 Marie Skłodowska-Curie Individual Fellowship
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Papers (8)：
Huu Hoang, Shinichiro Tsutsumi, Masanori Matsuzaki, Masanobu Kano, Mitsuo Kawato, Kazuo Kitamura, Keisuke Toyama. Dynamic organization of cerebellar climbing fiber response and synchrony in multiple functional components reduces dimensions for reinforcement learning. eLife. 2023. 12
Koji Ikezoe, Naoki Hidaka, Satoshi Manita, Masayoshi Murakami, Shinichiro Tsutsumi, Yoshikazu Isomura, Masanobu Kano, Kazuo Kitamura. Cerebellar climbing fibers multiplex movement and reward signals during a voluntary movement task in mice. Communications biology. 2023. 6. 1. 924-924
Huu Hoang, Shinichiro Tsutsumi, Masanori Matsuzaki, Masanobu Kano, Keisuke Toyama, Kazuo Kitamura, Mitsuo Kawato. Negative reward-prediction errors of climbing fiber inputs for cerebellar reinforcement learning algorithm. bioRxiv. 2023
Shinichiro Tsutsumi, Akiko Hayashi-Takagi. Optical interrogation of multi-scale neuronal plasticity underlying behavioral learning. Current opinion in neurobiology. 2021. 67. 8-15
Koji Ikezoe, Naoki Hidaka, Satoshi Manita, Masayoshi Murakami, Shinichiro Tsutsumi, Yoshikazu Isomura, Masanobu Kano, Kazuo Kitamura. Cerebellar climbing fibers convey behavioral information of multiplex modalities and form functional modules. bioRxiv. 2022. (preprint)
堤新一郎. Role of cerebellar stripes in cognitive behavior. 生体の科学. 2021. 72. 1
Shinichiro Tsutsumi, Mayumi Tada, Kenji Sakimura, Kazuo Kitamura, Masanobu Kano. Relationship between the synchrony of climbing fiber activities and the aldolase C compartments in mouse cerebellar cortex. JOURNAL OF PHYSIOLOGICAL SCIENCES. 2013. 63. S128-S128
Lectures and oral presentations (23)：
Cellular resolution circuit pathogenesis of autistic meltdown
(2024)
Thalamo-frontal circuit mechanisms for cognitive dysfunctions in psychiatric disorders
(2024)
Thalamo-frontal circuit mechanisms of autism spectrum disorder
(The 2nd RIKEN CBS Co-Creation International Conference 2023)
Thalamo-frontal cortex circuit mechanisms responsible for cognitive dysfunctions in psychiatric disorders
(The 46th Annual Meeting of the Japan Neuroscience Society 2023)
Thalamo-cortical circuit mechanisms responsible for cognitive dysfunctions in psychiatric disorders
(The 100th Anniversary Annual Meeting of The Physiological Society of Japan 2023)
