Rchr

J-GLOBAL ID：201201092609639321 Update date: Jan. 16, 2025

Yao Masahiro

ヤオマサヒロ | Yao Masahiro

Affiliation and department：
Homepage URL (1)： http://www-user.yokohama-cu.ac.jp/~urology/wp/

Research field (3)： Medical biochemistry , Pathobiochemistry , Urology

Research keywords (2)：分子腫瘍学 , 泌尿器科学

Research theme for competitive and other funds (42)：

2019 - 2022 Development of urine flow simulation in the kidney for risk classification and prevention of renal stone formation
2019 - 2022 PET/CTを活用した免疫チェックポイント阻害剤の血液バイオマーカーの同定
2019 - 2022 Elucidation of renal tumorigenesis under FLCN deficiency
2019 - 2022 Analyses of tumorigenesis and identifications of novel diagnostic marker and therapeutic target in hereditary and rare kidney cancers
2018 - 2022 Multistep carcinogenesis mechanism of renal cell carcinoma using human iPS cell-derived nephron induction and development of therapeutic platform

2016 - 2019 Elucidation of renal tumorigenesis driven by FLCN deficiency

2016 - 2019 Development of the novel therapy for renal cell carcinoma resistance to molecular targeting therapy using the assessment by FDG PET/CT

2015 - 2018 Clarification of the multistage carcinogenesis and basis of the innovative therapeutics for Renal Cell Carcinoma

2015 - 2018 Molecular Genetic analysis and Tumorigenesis of Birt-Hogg-Dube syndrome in Japan

2013 - 2016 The development of novel biomarker and treatment for renal cell carcinoma based on the assessment by FDG PET/CT

2013 - 2015 Development of visible light inducible photocatalytic nano-particles for the diagnosis of bladder cancer

2012 - 2015 Identification of molecular signatures associated with kidney cancer prognosis

2010 - 2012 Elucidation of Signal Networks to Stress in Renal Cell Carcinoma by Proteomic Analysis

2009 - 2011 Identification of gene signatures associated with renal tumor characteristics and its clinical applications

2007 - 2008 Development of the novel therapies targeting oncogenic signals of renal cell carcinoma

2006 - 2007 Establishment of an experimental therapy for aggressive renal cell carcinoma by knock-down of SPARC gene expression.

2006 - 2007 Construction of gene-expression predictor model for patient outcome with renal cell carcinoma

2005 - 2007 Analysis of cell polarity associated molecules in prostate cancer for the application to diagnosis and treatment

2005 - 2006 Development of novel renal cell carcinoma therapy targeting signal transduction pathways

2005 - 2006 リアル-タイムPCRを応用したVHL遺伝子診断法の新規開発

2004 - 2005 Prediction Model for Renal Carcinoma Recurrence based on the Gene Expressions.

2004 - 2004 性同一性障害者の性腺刺激ホルモン分泌調節中枢性機序「汎視床下部性分化異常」という新しい疾患概念の提出

2003 - 2004 MOLECULAR BIOLOGICAL RESEARCH ON THE PRECURSOR AND PRECANCEROUS LESIONS OF THE KIDNEY-ANALYSIS WITH LASER CAPTURE MICRODISSECTION AND CHROMOGENIC IN SITU HYBRIDIZATION-

2003 - 2004 Development of novel therapy

2002 - 2004 Analysis and detection of the molecules involving hormone refractory prostate cancer by applying Proteomics methodology

2002 - 2003 activation and its inhibition of invasion, metastasis and angiogenesis by HGF in renal cell carcinoma

2001 - 2003 Induction of neuronal differentiation of stem cell or cancer cell with VHL-gene transfer and neuronal regeneration using the transferred cells

2001 - 2002 ANALYSIS OF BIOLOGICAL MARKERS BENEFICIAL TO PREDICT BIOLOGIC BEHAVIOR S OF THE RENAL CELL CARCINOMAS BASED ON GENE EXPRESSION PROFILING.

2001 - 2002 Analysis of the VHL Tumor Suppressor Gene in Kidney Cancer

2000 - 2001 Role of Neuronal differentiation and Regeneration of VHL Tumor Suppressor Gene

1999 - 2001 Study of the identification of new genes inducing hormone refractory prostate cancer

1999 - 2001 Molecular detection of kidney cancers with VHL gene mutation in the blood, urine or lymph node

1998 - 2000 Study of the development a new type of treatment of urogenital cancer by using surface modified fine metal particles.

1998 - 1999 Functional Analysis of the von Hippel-Lindau Disease Tumor Suppressor Gene

1997 - 1998 ヒッペル・リンドウ病の遺伝子診断に関する国際間交流研究

1997 - 1998 Role of VHL tumor suppressor gene in central nervous system

1996 - 1997 Molecular Genetic Study of the VHL Tumor Suppressor Gene in Human Renal Cell Carcinoma

1996 - 1996 International study of von Hippel-Lindau disease

1995 - 1996 In vitro expression of von Hippel-Lindau tumor suppressor gene in human renal cell carcinoma by Herpes simplex virus vector

1994 - 1996 Molecular diagnosis of von Hippel-Lindau disease (VHL) using VHL tumor suppressor gene and the research for the VHL gene product

1994 - 1995 PATHOLOGICAL CLASSIFICATION AND CLINICAL SIGNIFICANCE OF BLADDER CANCER BASED ON MUTATION OF NUCLEAR ONCOGENE AND TUMOR SUPRESSOR GENE.

1994 - 1995 Mutational Analysis of the VHL Tumor Suppressor Gene in Sporadic Renal Cell Carcinoma

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Papers (502)：

Taku Mitome, Hiromichi Wakui, Kengo Azushima, Tatsuki Uehara, Ryosuke Jikuya, Shinji Ohtake, Go Noguchi, Sachi Kawaura, Yasuhiro Iribe, Kota Aomori, et al. SETD2 regulates SLC family transporter-mediated sodium and glucose reabsorptions in renal tubule. Biochemical and biophysical research communications. 2024. 734. 150730-150730
Hiroki Ito, Ryosuke Jikuya, Shohei Myoba, Tomoyuki Tatenuma, Go Noguchi, Daiki Ueno, Yusuke Ito, Mitsuru Komeya, Kentaro Muraoka, Masahiro Yao, et al. Tissue factor pathway inhibitor 2 (TFPI2) is a potential serum biomarker for clear cell renal carcinoma. Scientific reports. 2024. 14. 1. 28639-28639
野口剛, 軸屋良介, Wilan Krisna, 大竹慎二, 加藤生真, 舟崎慎太郎, 西澤秀和, 古屋充子, 古目谷暢, 三留拓, et al. iPS細胞から作製したALK関連腎癌オルガノイドの機能解析. 腎癌研究会会報. 2024. 54. 84-84
軸屋良介, 古屋充子, 加藤生真, 馬場理也, 野口剛, 川浦沙知, 入部康弘, 青盛恒太, 蓼沼知之, 伊藤悠城, et al. 嫌色素性腎細胞癌のがんの自然史および腫瘍内・腫瘍間不均一性獲得機構の解明. 腎癌研究会会報. 2024. 54. 85-85
軸屋良介, 蓮見壽史, 古屋充子, 加藤生真, 馬場理也, 三留拓, 大竹慎二, 野口剛, 川浦沙知, 伊藤悠亮, et al. シングルセルトランスクリプトーム解析を用いた遺伝性腎癌における腫瘍内不均一性と腫瘍微小環境の解明. 腎癌研究会会報. 2023. 53. 83-83

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MISC (433)：

野口剛, 軸屋良介, 大竹慎二, WILAN Krisna, 加藤生真, 古屋充子, 倉岡将平, 神波大己, 上村博司, 都築豊徳, et al. A novel kidney cancer organoid model derived from human iPS cells recapitulates an early stage of renal tumorigenesis. 日本癌学会学術総会抄録集(Web). 2024. 83rd
軸屋良介, 軸屋良介, JOHNSON Todd A., 前嶋和紘, 古屋充子, 加藤生真, 藤井誠志, 馬場理也, 浜之上はるか, 野口剛, et al. Elucidation of inter- and intra-tumor heterogeneity in chromophobe renal cell carcinomas and its related subtypes. 日本癌学会学術総会抄録集(Web). 2023. 82nd
Takashi Kawahara, Sahoko Ninomiya, Sohgo Tsutsumi, Hiroki Ito, Masahiro Yao, Hiroji Uemura. Impact of depression on overactive bladder. International Journal of Urology. 2021. 28. 2. 245-246
Wenjuan Ma, Takanobu Motoshima, Shintaro Funasaki, Yorifumi Satou, Benjy J. Y. Tan, Hisashi Hasumi, Mitsuko Furuya, Masahiro Yao, W. Marston Linehan, Yuichi Oike, et al. Regulation of hypoxia response pathway by chimeric TFE3s in Xp11.2 translocation renal cell carcinoma. CANCER SCIENCE. 2021. 112. 457-457
古目谷暢, 古目谷暢, 内田日出, 戸本幸志郎, 永田貴之, 高橋俊, 福田紘大, 木村啓志, 矢尾正祐, 松崎純一. The development of numerical urinary flow simulation system around a renal stone to facilitate spontaneous and asymptomatic stone expulsion. 日本泌尿器科学会総会(Web). 2020. 108回. 908-908

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Professional career (1)：

医学博士 (横浜市立大学)

Awards (1)：

2003 - 日本泌尿器科学会第11回日本泌尿器科学会学会賞受賞

Association Membership(s) (10)：

日本泌尿器腫瘍学会 , 日本VR医学会 , 日本尿路結石症学会 , JAPANESE SOCIETY OF GERIATRIC UROLOGY , LOW TEMPERATURE MEDICINE , 日本家族性腫瘍学会 , THE JAPAN SOCIETY OF HUMAN GENETICS , THE JAPANESE CANCER ASSOCIATION , JAPAN SOCIETY OF CLINICAL ONCOLOGY , THE JAPANESE UROLOGICAL ASSOCIATION

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