Shinobu Kitazume

Research field (2)： Pathobiochemistry , Functional biochemistry

Research keywords (21)： Amyloid precursor protein (APP) , Alzheimer's disease , 脳脊髄液 , Cerebral amyloid angiopathy , platelet , glioma , 血漿 , エキソペプチダーゼ , シアル酸転移酵素 , ST6Gal I , BACE1 , 分泌 , 肝炎 , サンドイッチELISA , ノックアウトマウス , 血管内皮細胞 , アポトーシス , 血管新生 , PECAM , シアル酸 , ゴルジ装置

Research theme for competitive and other funds (19)：

2024 - 2028 Overcoming amyloid-related imaging abnormalities associated with anti-amyloid-beta monoclonal antibodies
2021 - 2024 血管内アミロイド前駆体代謝産物を基軸とした多面的機能解析と臨床マーカーへの応用
2016 - 2019 Screening of PECAM antagonist having anti-tumor angiogenesis
2014 - 2017 A novel trafficking mechanism regulated by bisecting GlcNAc, an Alzheimer's disease accelerator
2014 - 2016 脳特異的な分岐型Oマンノース糖鎖がグリアアセンブリに果たす役割

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Papers (125)：

Kenichiro Nagai, Yui Muto, Saori Miura, Kazuto Takahashi, Yu Naruse, Ryo Hiruta, Yuko Hashimoto, Miwa Uzuki, Yoshimi Haga, Risa Fujii, et al. Brain-specific glycosylation enzyme GnT-IX maintains levels of protein tyrosine phosphatase receptor PTPRZ, thereby mediating glioma growth PTPRZ glycosylation regulates glioma growth. The Journal of biological chemistry. 2023. 299. 9. 105128-105128
Yuriko Tachida, Junko Iijima, Kazuto Takahashi, Hideaki Suzuki, Yasuhiko Kizuka, Yoshiki Yamaguchi, Katsunori Tanaka, Miyako Nakano, Daisuke Takakura, Nana Kawasaki, et al. O-GalNAc glycosylation determines intracellular trafficking of APP and Aβ production. The Journal of biological chemistry. 2023. 299. 7. 104905-104905
Kazuto Takahashi, Kenji Kanekiyo, Kanoko Sakuda, Yui Muto, Masahiro Iguchi, Nozomu Matsuda, Yuko Hashimoto, Kazuaki Kanai, Haruko Ogawa, Hajime Hirase, et al. Brain-specific glycosylation of protein tyrosine phosphatase receptor type Z ( PTPRZ ) marks a demyelination-associated astrocyte subtype. Journal of Neurochemistry. 2023
Ayano Fukui, Yuhei Maruzuru, Shiho Ohno, Moeka Nobe, Shuji Iwata, Kosuke Takeshima, Naoto Koyanagi, Akihisa Kato, Shinobu Kitazume, Yoshiki Yamaguchi, et al. Dual Impacts of a Glycan Shield on the Envelope Glycoprotein B of HSV-1: Evasion from Human Antibodies In Vivo and Neurovirulence. 2022
飯島順子, 芳賀淑美, 千葉靖典, 植田幸嗣, 西道隆臣, 佐原成彦, 北爪しのぶ. ADモデルマウスを用いたタウのO型糖鎖修飾の解析. 老年精神医学雑誌. 2022. 33. 増刊II. 240-240

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MISC (77)：

北爪しのぶ, 三浦里織, 立田由里子, 武藤優衣, 川口寧, 富本秀和, 佐原成彦, 斉藤貴史, 西道隆臣. 血中のAβおよびその関連分子の由来. Dementia Japan. 2021. 35. 4. 649-649
高橋一人, 兼清健志, 金井数明, 松田希, 井口正寛, 北爪しのぶ. Emergence of demyelination associated astrocytes in multiple sclerosis (MS) patients and model mice. 日本糖質学会年会要旨集. 2021. 40th
Kanoko Sakuda, Kenji Kanekiyo, Naoyuki Taniguchi, Shinobu Kitazume. The Role of Branched O-Mannosyl Glycan in Demyelination. TRENDS IN GLYCOSCIENCE AND GLYCOTECHNOLOGY. 2019. 31. 180. E77-E85
作田香子, 作田香子, 兼清健志, 兼清健志, 谷口直之, 谷口直之, 北爪しのぶ, 北爪しのぶ. The Role of Branched O-Mannosyl Glycan in Demyelination. Trends in Glycoscience and Glycotechnology (Web). 2019. 31. 180
作田香子, 兼清健志, 谷口直之, 北爪しのぶ. 日本糖質学会編集論文脱髄における分岐型O-マンノース糖鎖の機能. Trends in glycoscience and glycotechnology. 2019. 31. 178-180. J77-85

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Patents (5)：

糖鎖を含む抗原ポリペプチドの作製方法
グリオーマ検出用バイオマーカー
急性冠症候群のマーカー及びその利用
認知症診断の為の可溶型アミロイドβ前駆体タンパク質770β切断産物の検出方法
血清糖蛋白質をバイオマーカーとするアルツハイマー病の診断方法

Work history (1)：

1990/04 - 1995/03 The University of Tokyo Graduate School of Science Department of Biophysics and Biochemistry

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