Rchr
J-GLOBAL ID：201201093602458344   Update date: Jan. 17, 2024

Ogata Kazuhiro

オガタ カズヒロ | Ogata Kazuhiro
Affiliation and department：
Yokohama City University School of Medicine, Medical Course, Biochemistry, Medical Studies

About Yokohama City University School of Medicine, Medical Course, Biochemistry, Medical Studies


Job title： Professor
Homepage URL  (1)： http://www-user.yokohama-cu.ac.jp/~seika/index.html
Research field  (10)： Pathobiochemistry ,  Medical biochemistry ,  Pharmaceuticals - health and biochemistry ,  Molecular biology ,  Biophysics ,  Functional biochemistry ,  Structural biochemistry ,  Molecular biochemistry ,  Nanobioscience ,  Nanomaterials
Research keywords  (55)： 分子腫瘍学 ,  生体分子医学 ,  分子生物学 ,  生化学 ,  遺伝情報複製・転写装置・再編・制御 ,  生体高分子構造・機能 ,  1分子計測・操作 ,  タンパク質・核酸の構造・動態・機能 ,  遺伝子の情報発現と複製 ,  酵素の作用機作と調節 ,  X線結晶解析 ,  構造生物学 ,  NMR ,  生体分子立体構造解析及び予測 ,  分子認識 ,  翻訳後修飾 ,  生体物質の機器分析 ,  遺伝子及び染色体 ,  核酸 ,  タンパク質と酵素 ,  構造活性相関 ,  活性発現の分子機構 ,  化学修飾 ,  生体高分子 ,  1分子ナノ計測 ,  1分子科学一般 ,  1分子生理・生化学 ,  Molecular Oncology ,  Biomolecular Medicine ,  Structural Biology 6803 ,  Molecular Biology ,  Biochemistry ,  Genetic Information Replication/Transcription Devices/Reorganization/Control ,  Living Body Polymer Structure/Function ,  One-Molecule Measurement/Manipulation ,  Structure/Movement/Function of Protein/Nucleic Acid ,  Genetic Expression and Reproduction of Information ,  Action Mechanism and Modification of Enzyme ,  X-Ray Crystallography Analysis ,  Structural Biology ,  NMR ,  Biomolecule Steric Structural Analysis and Forecasts ,  Molecular Recognition ,  Posttranslational Modifications ,  Machine Analysis of Organisms ,  Gene and Chromosome ,  Nucleic Acid ,  Protein and Enzyme ,  Structure-Activity Relationship ,  Molecular Mechanism of Activity Expression ,  Chemical Modification ,  Bio-Polymer ,  Nano-Measurement of One- Molecule ,  Monomolecular General Science ,  Physiology/Biochemistry at One-Molecule Level
Research theme for competitive and other funds  (7)：
  • 2018 - 2020 ヌクレオソームーエンハンソソーム変換の機構の解明
  • 2016 - 2019 がん関連転写因子Runx1/CBFβを標的とした活性制御薬物の研究
  • 2012 - 2016 静的・動的分子構造解析を基盤とした転写サイクル制御機構研究
  • 2005 - 2009 Mechanism for regulation of DECODE complexes in gene activation
  • 2004 - 2005 Study of molecular structural and dynamical aspects of transcriptional regulatory factors
Show all
Papers (137)：
  • Toru Sengoku, Masaaki Shiina, Kae Suzuki, Keisuke Hamada, Ko Sato, Akiko Uchiyama, Shunsuke Kobayashi, Asako Oguni, Hayato Itaya, Kota Kasahara, et al. Structural basis of transcription regulation by CNC family transcription factor, Nrf2. Nucleic Acids Research. 2022. 50. 21. 12543-12557
  • Alexander A. Vinogradov, Yue Zhang, Keisuke Hamada, Jun Shi Chang, Chikako Okada, Hirotaka Nishimura, Naohiro Terasaka, Yuki Goto, Kazuhiro Ogata, Toru Sengoku, et al. De Novo Discovery of Thiopeptide Pseudo-natural Products Acting as Potent and Selective TNIK Kinase Inhibitors. Journal of the American Chemical Society. 2022. 144. 44. 20332-20341
  • Yuchen Zhang, Keisuke Hamada, Dinh Thanh Nguyen, Sumika Inoue, Masayuki Satake, Shunsuke Kobayashi, Chikako Okada, Kazuhiro Ogata, Masahiro Okada, Toru Sengoku, et al. LimF is a versatile prenyltransferase for histidine-C-geranylation on diverse non-natural substrates. Nature Catalysis. 2022
  • Kohei Hamanaka, Keita Miyoshi, Jia-Hui Sun, Keisuke Hamada, Takao Komatsubara, Ken Saida, Naomi Tsuchida, Yuri Uchiyama, Atsushi Fujita, Takeshi Mizuguchi, et al. Amelioration of a neurodevelopmental disorder by carbamazepine in a case having a gain-of-function GRIA3 variant. Human genetics. 2022
  • Ko Sato, Amarjeet Kumar, Keisuke Hamada, Chikako Okada, Asako Oguni, Ayumi Machiyama, Shun Sakuraba, Tomohiro Nishizawa, Osamu Nureki, Hidetoshi Kono, et al. Structural basis of the regulation of the normal and oncogenic methylation of nucleosomal histone H3 Lys36 by NSD2. Nature communications. 2021. 12. 1. 6605-6605
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MISC (29)：
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Patents (3)：
Books (6)：
  • 見てわかる構造生命科学 : 生命科学研究へのタンパク質構造の利用
    化学同人 2014 ISBN:9784759815771
  • 転写制御とエピジェネティクス
    南山堂 2008
  • 実験医学別冊 生命科学のための機器分析実験ハンドブック 第8章 Biacore-タンパク質とリガンドとの相互作用の解析-
    羊土社 2007
  • 分子生物学実験シリーズ「図・写真で観るタンパク構造・機能解析実験実践ガイド」 タンパク質の立体構造解析を行うために-分子構造解析のためのタンパク質試料調整法
    2005
  • The c-Myb DNA binding domain: from molecular structure to function ed. by J. Frampton. Myb Transcription Factors: Their Role in Growth, Differentiation and Disease (pp.223-238)
    2004
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Lectures and oral presentations  (24)：
  • Molecular behavior of a higher-order complex of multiple transcription factors on enhancer site upon phosphorylation
    (6th International Conference on Structural Biology - Structural Biology 2016 2016)
  • Molecular mechanism for modulation of a multiple transcription factor complex formed on enhancer site up on phosphorylation
    (5th International Conference and Exhibition on Metabolomics 2016)
  • Structural analyses for the effects of Ets1 phosphorylation on Ets1-containing TF-DNA assemblies
    (HUPO 2013(12th Human Proteome Organization Annual World Congress) 2013)
  • Crystal structural analysis of drosophila nucleosome assembly protein
    (4th International Symposium on Diffraction Structural Biology 2013)
  • DNA-mediated allosteric regulation in a complex of multiple transcription factors with DNA
    (4th International Symposium on Diffraction Structural Biology 2013)
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Professional career (1)：
  • 博士(医学) (横浜市立大学)
Association Membership(s) (5)：
THE JAPANESE CANCER ASSOCIATION ,  THE CRYSTALLOGRAPHIC SOCIETY OF JAPAN ,  THE BIOPHYSICAL SOCIETY OF JAPAN ,  THE MOLECULAR BIOLOGY SOCIETY OF JAPAN ,  THE JAPANESE BIOCHEMICAL SOCIETY
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