Rchr
J-GLOBAL ID:201201095903445879   Update date: Oct. 15, 2024

Yamashita Akio

ヤマシタ アキオ | Yamashita Akio
Affiliation and department:
Homepage URL  (2): https://yamashita-lab.labby.jp/https://yamashita-lab-en.labby.jp/
Research field  (2): Medical biochemistry ,  Molecular biology
Research keywords  (6): Post-Transcriptional Control of Gene Expression ,  SMG1 ,  mRNA decay ,  mRNA translation ,  Nonsense-mediated mRNA decay ,  mRNA surveillance
Research theme for competitive and other funds  (23):
  • 2021 - 2023 がん抗原の発現増強の新手法としてのmRNA監視機構阻害
  • 2020 - 2023 ポスト翻訳終結イベントの調節機構及びその生理病理的意義の解明
  • 2020 - 2023 A pathophysiological significance of receptor-binding factor in aging-associated cerebral cardiovascular disease
  • 2020 - 2023 ゲノム編集法を用いたヒトパピローマウイルスの細胞感染機構の解明
  • 2018 - 2022 Therapeutic Strategy against Renal Aging via Novel Dual Actions of Receptor-binding Molecule
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Papers (113):
  • Mitsuhiro Machitani, Akira Nomura, Taro Yamashita, Mami Yasukawa, Saori Ueki, Ken-Ichi Fujita, Toshihide Ueno, Akio Yamashita, Yoshikazu Tanzawa, Masahiko Watanabe, et al. Maintenance of R-loop structures by phosphorylated hTERT preserves genome integrity. Nature cell biology. 2024. 26. 6. 932-945
  • Hirotatsu Imai, Akio Yamashita. Metabolic RNA Labeling and Translating Ribosome Affinity Purification for Measurement of Nascent RNA Translation. BIO-PROTOCOL. 2024. 14. 1355
  • Keigo Hirota, Akio Yamashita, Eriko Abe, Takahiro Yamaji, Kengo Azushima, Shohei Tanaka, Shinya Taguchi, Shunichiro Tsukamoto, Hiromichi Wakui, Kouichi Tamura. miR-125a-5p/miR-125b-5p contributes to pathological activation of Angiotensin II-AT1R in mouse distal convoluted tubule cells by the suppression of Atrap. The Journal of biological chemistry. 2023. 299. 12. 105478-105478
  • Shinya Taguchi, Kengo Azushima, Takahiro Yamaji, Toru Suzuki, Eriko Abe, Shohei Tanaka, Keigo Hirota, Shunichiro Tsukamoto, Ryutaro Morita, Ryu Kobayashi, et al. Angiotensin II type 1 receptor-associated protein deletion combined with angiotensin II stimulation accelerates the development of diabetic kidney disease in mice on a C57BL/6 strain. Hypertension research : official journal of the Japanese Society of Hypertension. 2023. 47. 1. 55-66
  • Shunichiro Tsukamoto, Hiromichi Wakui, Tatsuki Uehara, Yuka Shiba, Kengo Azushima, Eriko Abe, Shohei Tanaka, Shinya Taguchi, Keigo Hirota, Shingo Urate, et al. Combination of sacubitril/valsartan and blockade of the PI3K pathway enhanced kidney protection in a mouse model of cardiorenal syndrome. European heart journal open. 2023. 3. 6. oead098
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MISC (57):
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Patents (5):
Education (1):
  • 1998 - 2001 Yokohama City University Graduate School of Medicine Department of Molecular biology
Professional career (1):
  • Ph. D (Yokohama City University graduate school of Medicine)
Work history (3):
  • 2021/02 - 現在 University of the Ryukyus
  • 2010/04 - 2021/01 Yokohama City University School of Medicine Medical Course Molecular Biology Graduate School of Medicine Degree Program Associate Professor
  • 2007/10 - 2011/03 Japan Science and Technology Agency PREST, RNA and biofunction PREST researcher
Awards (3):
  • 2011/11 - 日本分子生物学会 三菱化学奨励賞 動物細胞における mRNA 監視機構の分子機構の研究
  • 2011/04 - 文部科学省 科学技術分野の文部科学大臣表彰 若手科学者賞 mRNA監視機構による遺伝子発現制御の研究
  • 2011/04 - 横浜市立大学医学会 医学会賞 mRNA品質管理機構の分子基盤と医療応用
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