Art

J-GLOBAL ID：201202201781591958   Reference number：12A1692520

Hotspot Mutations in H3F3A and IDH1 Define Distinct Epigenetic and Biological Subgroups of Glioblastoma

H3F3A及びIDH1におけるホットスポット突然変異は膠芽細胞腫の異なるエピジェネティック亜群と生物学的亜群を明らかにする

Author (40)： STURM Dominik (Div. of Pediatric Neurooncology, German Cancer Res. Center (DKFZ) Heidelberg, 69120 Heidelberg, DEU) ,  WITT Hendrik (Div. of Pediatric Neurooncology, German Cancer Res. Center (DKFZ) Heidelberg, 69120 Heidelberg, DEU) ,  WITT Hendrik (Dep. of Pediatric Oncology, Hematology, and Immunology, Heidelberg Univ. Hospital, 69120 Heidelberg, DEU) ,  HOVESTADT Volker (Div. of Molecular Genetics, German Cancer Res. Center (DKFZ) Heidelberg, 69120 Heidelberg, DEU) ,  KHUONG-QUANG Dong-anh (Departments of Pediatrics and Human Genetics, McGill Univ., McGill Univ. Health Center Res. Inst., Montreal, QC H3Z ...) ,  JONES David T.W. (Div. of Pediatric Neurooncology, German Cancer Res. Center (DKFZ) Heidelberg, 69120 Heidelberg, DEU) ,  KONERMANN Carolin (Div. of Epigenetics and Cancer Risk Factors, German Cancer Res. Center (DKFZ) Heidelberg, 69120 Heidelberg, DEU) ,  PFAFF Elke (Div. of Pediatric Neurooncology, German Cancer Res. Center (DKFZ) Heidelberg, 69120 Heidelberg, DEU) ,  TOENJES Martje (Div. of Molecular Genetics, German Cancer Res. Center (DKFZ) Heidelberg, 69120 Heidelberg, DEU) ,  SILL Martin (Div. of Biostatistics, German Cancer Res. Center (DKFZ) Heidelberg, 69120 Heidelberg, DEU) ,  BENDER Sebastian (Div. of Pediatric Neurooncology, German Cancer Res. Center (DKFZ) Heidelberg, 69120 Heidelberg, DEU) ,  KOOL Marcel (Div. of Pediatric Neurooncology, German Cancer Res. Center (DKFZ) Heidelberg, 69120 Heidelberg, DEU) ,  ZAPATKA Marc (Div. of Molecular Genetics, German Cancer Res. Center (DKFZ) Heidelberg, 69120 Heidelberg, DEU) ,  BECKER Natalia (Div. of Biostatistics, German Cancer Res. Center (DKFZ) Heidelberg, 69120 Heidelberg, DEU) ,  ZUCKNICK Manuela (Div. of Biostatistics, German Cancer Res. Center (DKFZ) Heidelberg, 69120 Heidelberg, DEU) ,  HIELSCHER Thomas (Div. of Biostatistics, German Cancer Res. Center (DKFZ) Heidelberg, 69120 Heidelberg, DEU) ,  LIU Xiao-yang (Departments of Pediatrics and Human Genetics, McGill Univ., McGill Univ. Health Center Res. Inst., Montreal, QC H3Z ...) ,  FONTEBASSO Adam M. (Div. of Experimental Medicine, Montreal Children’s Hospital, McGill Univ. Health Center Res. Inst., Montreal, QC ...) ,  RYZHOVA Marina (NN Burdenko Neurosurgical Inst., Moscow, 125047, RUS) ,  ALBRECHT Steffen (Dep. of Pathology, Montreal Children’s Hospital, McGill Univ. Health Center Res. Inst., Montreal, QC H3H 1P3, CAN) ,  JACOB Karine (Departments of Pediatrics and Human Genetics, McGill Univ., McGill Univ. Health Center Res. Inst., Montreal, QC H3Z ...) ,  WOLTER Marietta (Dep. of Neuropathology, Heinrich-Heine-University, 40225 Duesseldorf, DEU) ,  EBINGER Martin (Dep. of Hematology and Oncology, Children’s Univ. Hospital Tuebingen, 72076 Tuebingen, DEU) ,  SCHUHMANN Martin U. (Dep. of Neurosurgery, Univ. Hospital Tuebingen, 76076 Tuebingen, DEU) ,  VAN METER Timothy (Virginia Commonwealth Univ., Richmond, VA 23298, USA) ,  FRUEHWALD Michael C. (Pediatric Hospital, Klinikum Augsburg, 86156 Augsburg, DEU) ,  HAUCH Holger (Pediatric Hospital, Klinikum Heilbronn, 74078 Heilbronn, DEU) ,  PEKRUN Arnulf (Prof.-Hess-Kinderklinik, Klinikum Bremen-Mitte, 28177 Bremen, DEU) ,  RADLWIMMER Bernhard (Div. of Molecular Genetics, German Cancer Res. Center (DKFZ) Heidelberg, 69120 Heidelberg, DEU) ,  NIEHUES Tim (Children’s Hospital, Helios Clinics, 47805 Krefeld, DEU) ,  VON KOMOROWSKI Gregor (Children’s Univ. Hospital, 68135 Mannheim, DEU) ,  DUERKEN Matthias (Children’s Univ. Hospital, 68135 Mannheim, DEU) ,  KULOZIK Andreas E. (Dep. of Pediatric Oncology, Hematology, and Immunology, Heidelberg Univ. Hospital, 69120 Heidelberg, DEU) ,  MADDEN Jenny (Dep. of Pediatrics, Univ. of Colorado Denver, Aurora, CO 80045, USA) ,  DONSON Andrew (Dep. of Pediatrics, Univ. of Colorado Denver, Aurora, CO 80045, USA) ,  FOREMAN Nicholas K. (Dep. of Pediatrics, Univ. of Colorado Denver, Aurora, CO 80045, USA) ,  DRISSI Rachid (Div. of Oncology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229, USA) ,  FOULADI Maryam (Div. of Oncology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229, USA) ,  SCHEURLEN Wolfram ,  VON DEIMLING Andreas
Material： Cancer Cell
Volume： 22  Issue： 4  Page： 425-437  Publication year： Oct. 16, 2012 
JST Material Number： W1844A  ISSN： 1535-6108  Document type： Article
Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Terms in the title (6)： IDH1 ,  ホットスポット ,  突然変異 ,  膠芽細胞腫 ,  エピジェネティック ,  生物学