Art

J-GLOBAL ID：201202203036684580   Reference number：12A1327630

Directed differentiation of human pluripotent stem cells into mature airway epithelia expressing functional CFTR protein

機能性CFTRタンパク質を発現する成熟気道上皮へヒト多能性幹細胞を分化させる

Author (13)： WONG Amy P (Hospital for Sick Children, Ontario, CAN) ,  PASCERI Peter (Hospital for Sick Children, Ontario, CAN) ,  ELLIS James (Hospital for Sick Children, Ontario, CAN) ,  ROSSANT Janet (Hospital for Sick Children, Ontario, CAN) ,  WONG Amy P (Ontario Human Induced Pluripotent Stem Cell Facility, Ontario, CAN) ,  THOMPSON Tadeo O (Ontario Human Induced Pluripotent Stem Cell Facility, Ontario, CAN) ,  ELLIS James (Ontario Human Induced Pluripotent Stem Cell Facility, Ontario, CAN) ,  BEAR Christine E (Hospital for Sick Children, Ontario, CAN) ,  CHIN Stephanie (Hospital for Sick Children, Ontario, CAN) ,  HUAN Ling-Jun (Hospital for Sick Children, Ontario, CAN) ,  RATJEN Felix (Hospital for Sick Children, Ontario, CAN) ,  ELLIS James (Univ. Toronto, Ontario, CAN) ,  ROSSANT Janet (Univ. Toronto, Ontario, CAN)
Material： Nature Biotechnology  (Nat Biotechnol)
Volume： 30  Issue： 9  Page： 876-882  Publication year： Sep. 2012 
JST Material Number： H0870A  ISSN： 1087-0156  Document type： Article
Article type： 短報  Country of issue： United States (USA)  Language： ENGLISH (EN)

Thesaurus term： *cell differentiation ,  *human(primates) ,  *epithelium ,  *chloride channel ,  *cystic fibrosis ,  gene expression ,  *protocol ,  *in vitro experiment ,  *experimental disease ,  inspection ,  *stem cell ,  *cultured cell ,  DNA binding protein ,  transcription factor ,  oncoprotein ,  biomarker ,  *induced pluripotent stem cell
Semi thesaurus term： c-Myc ,  *in vitro定向分化プロトコル ,  KLF4 ,  NANOGマーカー ,  Sox2 ,  TRA1-60マーカー ,  TRA1-81マーカー ,  *ヒト多能性幹細胞 ,  Oct-4 ,  患者特異的気道上皮細胞 ,  *Airway epithelium ,  *Induced Pluripotent Stem Cells ,  多能性マーカー ,  *Cystic Fibrosis Transmembrane Conductance Regulator ,  Drug test

JST classification (4)： Cell physiology in general  (EF02010S) ,  Culture engineering in general  (FK02010I) ,  Basic medicine on respiratory system  (GI01020H) ,  Research methods  (GV01020U)

Terms in the title (9)： 機能性 ,  CFTR ,  タンパク質 ,  発現 ,  成熟 ,  気道上皮 ,  ヒト ,  多能性幹細胞 ,  分化