Art

J-GLOBAL ID：201202207233254097   Reference number：12A0721457

Efficient Intradermal Delivery of Superoxide Dismutase Using a Combination of Liposomes and Iontophoresis for Protection against UV-Induced Skin Damage

UV誘発皮膚損傷に対する保護のためにリポソームとイオントフォレーシスの組み合わせを用いたスーパーオキシドジスムターゼの効率的皮内デリバリー

Author (6)： KIGASAWA Kaoru (Graduate School of Life Sci., Hokkaido Univ.) ,  MIYASHITA Moeko (Graduate School of Life Sci., Hokkaido Univ.) ,  KAJIMOTO Kazuaki (Fac. of Pharmaceutical Sciences, Hokkaido Univ.) ,  KANAMURA Kiyoshi (TTI Ellebeau Inc.) ,  HARASHIMA Hideyoshi (Fac. of Pharmaceutical Sciences, Hokkaido Univ.) ,  KOGURE Kentaro (Dep. of Biophysical Chemistry, Kyoto Pharmaceutical Univ.)
Material： Biological and Pharmaceutical Bulletin  (Biological & Pharmaceutical Bulletin)
Volume： 35  Issue： 5  Page： 781-785 (J-STAGE)  Publication year： 2012 
JST Material Number： S0989A  ISSN： 0918-6158  CODEN： BPBLEO  Document type： Article
Article type： 短報  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *Superoxide Dismutase ,...
Semi thesaurus term： UV light ,...

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JST classification (3)： Enzyme in general  (EB09010D) ,  Basic biopharmacy  (GY01021U) ,  Basic dermatology  (GF01020Y)

Substance index (3)： 8-Hydroxy-2'-deoxyguanosine ,  Malondialdehyde ,  N6-Hexanoyl-L-lysine

Reference (23)：

• 1) Bickers DR, Athar M. Oxidative stress in the pathogenesis of skin disease. J. Invest. Dermatol., 126, 2565—2575 (2006).
• 2) Vaille A, Jadot G, Elizagaray A. Anti-inflammatory activity of various superoxide dismutases on polyarthritis in the Lewis rat. Biochem. Pharmacol., 39, 247—255 (1990).
• 3) Simões SI, Delgado TC, Lopes RM, Jesus S, Ferreira AA, Morais JA, Cruz ME, Corvo ML, Martins MB. Developments in the rat adjuvant arthritis model and its use in therapeutic evaluation of novel non-invasive treatment by SOD in transfersomes. J. Control. Release, 103, 419—434 (2005).
• 4) Bos JD, Meinardi MM. The 500 Dalton rule for the skin penetration of chemical compounds and drugs. Exp. Dermatol., 9, 165—169 (2000).
• 5) Prausnitz MR, Langer R. Transdermal drug delivery. Nat. Biotechnol., 26, 1261—1268 (2008).

Terms in the title (7)： 誘発 ,  皮膚損傷 ,  リポソーム ,  イオントフォレーシス ,  組み合わせ ,  スーパーオキシドジスムターゼ ,  デリバリー