Art

J-GLOBAL ID：201202207972592308   Reference number：12A0883449

Searching for new cell-penetrating agents: hybrid cyclobutane-proline γ,γ-peptides

新規な細胞浸透剤の探索: ハイブリッドシクロブタン-プロリンγ,γ-ペプチド類

Author (9)： GORREA Esther (Universitat Autonoma de Barcelona, Cerdanyola del Valles, ESP) ,  CARBAJO Daniel (Univ. Barcelona, Barcelona, ESP) ,  CARBAJO Daniel (CIBER-BBN, Barcelona, ESP) ,  GUTIERREZ-ABAD Raquel (Universitat Autonoma de Barcelona, Cerdanyola del Valles, ESP) ,  ILLA Ona (Universitat Autonoma de Barcelona, Cerdanyola del Valles, ESP) ,  BRANCHADELL Vicenc (Universitat Autonoma de Barcelona, Cerdanyola del Valles, ESP) ,  ROYO Miriam (Univ. Barcelona, Barcelona, ESP) ,  ROYO Miriam (CIBER-BBN, Barcelona, ESP) ,  ORTUNO Rosa M. (Universitat Autonoma de Barcelona, Cerdanyola del Valles, ESP)
Material： Organic & Biomolecular Chemistry  (Org Biomol Chem)
Volume： 10  Issue： 20  Page： 4050-4057  Publication year： May. 28, 2012 
JST Material Number： A0499C  ISSN： 1477-0520  CODEN： OBCRAK  Document type： Article
Article type： 原著論文  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Thesaurus term： chemical synthesis ,  *oligopeptide ,  alicyclic compound ,  *aminocarboxylic acid ,  amino acid ,  nitrogen heterocyclic compound ,  chain length effect ,  property ,  side chain ,  solid phase synthesis ,  cytotoxicity ,  endocytosis
Semi thesaurus term： γ,γ-ペプチド ,  chirality ,  Cyclobutanes ,  proline derivative ,  intracellular uptake ,  *Cell Membrane Permeability

JST classification (1)： Peptides  (CF10080G)

Substance index (15)： 5(6)-Carboxyfluorescein ,  (1R)-2,2-Dimethyl-3β-[[(4S)-1-(tert-butoxycarbonyl)-4α-(benzyloxycarbonylamino)-L-prolyl]amino]cyclobutane-1β-carboxylic acid methyl ester ,  (1S)-2,2-Dimethyl-3α-[[(4S)-1-(tert-butoxycarbonyl)-4α-(benzyloxycarbonylamino)-L-prolyl]amino]cyclobutane-1α-carboxylic acid methyl ester ,  (1R)-2,2-Dimethyl-3β-[[(4S)-1-(tert-butoxycarbonyl)-4α-[[(1R)-2,2-dimethyl-3β-[[(4S)-1-(tert-butoxycarbonyl)-4α-(benzyloxycarbonylamino)-L-Pro-]amino]cyclobutane-1β-yl]carbonylamino]-L-Pro-]amino]cyclobutane-1β-carboxylic acid methyl ester ,  (1S)-2,2-Dimethyl-3α-[[(4S)-1-(tert-butoxycarbonyl)-4α-[[(1S)-2,2-dimethyl-3α-[[(4S)-1-(tert-butoxycarbonyl)-4α-(benzyloxycarbonylamino)-L-Pro-]amino]cyclobutane-1α-yl]carbonylamino]-L-Pro-]amino]cyclobutane-1α-carboxylic acid methyl ester ,  (1R)-2,2-Dimethyl-3β-[[(4S)-1-(tert-butoxycarbonyl)-4α-[[(1R)-2,2-dimethyl-3β-[[(4S)-1-(tert-butoxycarbonyl)-4α-[[(1R)-2,2-dimethyl-3β-[[(4S)-1-(tert-butoxycarbonyl)-4α-(benzyloxycarbonylamino)-L-Pro-]amino]cyclobutane-1β-yl]carbonylamino]-L-Pro-]amino]cyclobutane-1β-yl]carbonylamino]-L-Pro-]amino]cyclobutane-1β-carboxylic acid methyl ester ,  (1S)-2,2-Dimethyl-3α-[[(4S)-1-(tert-butoxycarbonyl)-4α-[[(1S)-2,2-dimethyl-3α-[[(4S)-1-(tert-butoxycarbonyl)-4α-[[(1S)-2,2-dimethyl-3α-[[(4S)-1-(tert-butoxycarbonyl)-4α-(benzyloxycarbonylamino)-L-Pro-]amino]cyclobutane-1α-yl]carbonylamino]-L-Pro-]amino]cyclobutane-1α-yl]carbonylamino]-L-Pro-]amino]cyclobutane-1α-carboxylic acid methyl ester ,  (1S)-2,2-Dimethyl-3α-(benzyloxycarbonylamino)cyclobutane-1α-carboxylic acid tert-butyl ester ,  (1S)-2,2-Dimethyl-3α-(9H-fluorene-9-ylmethoxycarbonylamino)cyclobutane-1α-carboxylic acid tert-butyl ester ,  1-(tert-Butoxycarbonyl)-4α-(9H-fluoren-9-ylmethoxycarbonylamino)-L-proline ,  (4S)-1-(5-Guanidinopentanoyl)-4α-[[(1S)-2,2-dimethyl-3α-[[(4S)-1-(5-guanidinopentanoyl)-4α-[[(1S)-2,2-dimethyl-3α-[[(4S)-1-(5-guanidinopentanoyl)-4α-[[(1S)-2,2-dimethyl-3α-aminocyclobutane-1α-yl]carbonylamino]-L-prolyl]amino]cyclobutane-1α-yl]carbonylamino]-L-prolyl]amino]cyclobutane-1α-yl]carbonylamino]-L-prolinamide ,  (4S)-1-Amidino-4α-[[(1S)-2,2-dimethyl-3α-[[(4S)-1-amidino-4α-[[(1S)-2,2-dimethyl-3α-[[(4S)-1-amidino-4α-[[(1S)-2,2-dimethyl-3α-aminocyclobutane-1α-yl]carbonylamino]-L-prolyl]amino]cyclobutane-1α-yl]carbonylamino]-L-prolyl]amino]cyclobutane-1α-yl]carbonylamino]-L-prolinamide ,  1-(Trifluoromethylsulfonyl)-2,3-bis(tert-butoxycarbonyl)guanidine ,  N,N′-Bis(tert-butoxycarbonyl)-1H-pyrazole-1-formamidine ,  (4S)-1-(5-Guanidinopentanoyl)-4α-amino-L-prolinamide

Terms in the title (6)： 細胞 ,  浸透剤 ,  探索 ,  シクロブタン ,  プロリン ,  ペプチド類