Art

J-GLOBAL ID：201202213447066395   Reference number：12A0424025

Activation-induced cytidine deaminase (AID)-dependent somatic hypermutation requires a splice isoform of the serine/arginine-rich (SR) protein SRSF1

活性化誘導のシチジンデアミナーゼ(AID)依存性体細胞超変異はセリン/アルギニンリッチ(SR)蛋白質SRSF1のスプライシングアイソフォームを必要とする

Author (15)： KANEHIRO Yuichi (Okayama Univ. Graduate School of Natural Sci. and Technol., Okayama, JPN) ,  KANEHIRO Yuichi (Shimane Univ. School of Medicine, Shimane, JPN) ,  TODO Kagefumi (Okayama Univ. Graduate School of Natural Sci. and Technol., Okayama, JPN) ,  TODO Kagefumi (Kyoto Univ. Graduate School of Medicine, Kyoto, JPN) ,  NEGISHI Misaki (Okayama Univ. Graduate School of Natural Sci. and Technol., Okayama, JPN) ,  FUKUOKA Junji (Okayama Univ. Graduate School of Natural Sci. and Technol., Okayama, JPN) ,  GAN Wenjian (National Inst. Biological Sci., Beijing, CHN) ,  HIKASA Takuya (Okayama Univ. Graduate School of Natural Sci. and Technol., Okayama, JPN) ,  KAGA Yoshiaki (Okayama Univ. Graduate School of Natural Sci. and Technol., Okayama, JPN) ,  TAKEMOTO Masayuki (Okayama Univ. Graduate School of Natural Sci. and Technol., Okayama, JPN) ,  MAGARI Masaki (Okayama Univ. Graduate School of Natural Sci. and Technol., Okayama, JPN) ,  LI Xialu (National Inst. Biological Sci., Beijing, CHN) ,  MANLEY James L. (Columbia Univ., NY) ,  OHMORI Hitoshi (Okayama Univ. Graduate School of Natural Sci. and Technol., Okayama, JPN) ,  KANAYAMA Naoki (Okayama Univ. Graduate School of Natural Sci. and Technol., Okayama, JPN)
Material： Proceedings of the National Academy of Sciences of the United States of America  (PNAS)
Volume： 109  Issue： 4  Page： 1216-1221  Publication year： Jan. 24, 2012 
JST Material Number： D0387A  ISSN： 0027-8424  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Thesaurus term： activation ,  *cytidine deaminase ,  *mutation ,  *somatic cell ,  *splicing factor ,  *protein ,  morphology(form) ,  Gallus gallus domesticus ,  cultured cell ,  tumor cell ,  gene expression ,  amino acid sequence ,  immunoglobulin fragment ,  gene ,  immunoglobulin ,  RNA ,  transcription(genetics) ,  B cell
Semi thesaurus term： B lymphocyte ,  B cell (lymphocyte) ,  DT40 cell ,  isoform ,  *serine/arginine-rich protein ,  overexpression ,  Cell Line ,  *somatic hypermutation ,  transcript ,  Immunoglobulin Variable Region

JST classification (6)： Enzyme in general  (EB09010D) ,  Genetic variation  (EC01030Y) ,  Cytology in general  (EF01000A) ,  Proteins and peptides in general  (EB03010N) ,  Nucleic acids in general  (EB04010U) ,  Leukocytes,lymphocytes  (EJ03030H)

Terms in the title (10)： 活性化 ,  誘導 ,  シチジンデアミナーゼ ,  AID ,  依存性 ,  体細胞超変異 ,  セリン ,  Sr ,  蛋白質 ,  SRSF1