Art

J-GLOBAL ID：201202213882712134   Reference number：12A1063510

Structure-Guided Evolution of Potent and Selective CHK1 Inhibitors through Scaffold Morphing

足場モーフィングを通じて強力かつ選択的CHK1阻害剤の構造誘導化の進化

Author (28)： READER John C. (Sareum Ltd., Cambridge, GBR) ,  MATTHEWS Thomas P. (Inst. of Cancer Res., Surrey, GBR) ,  KLAIR Suki (Sareum Ltd., Cambridge, GBR) ,  CHEUNG Kwai-Ming J. (Inst. of Cancer Res., Surrey, GBR) ,  SCANLON Jane (Sareum Ltd., Cambridge, GBR) ,  PROISY Nicolas (Inst. of Cancer Res., Surrey, GBR) ,  ADDISON Glynn (Sareum Ltd., Cambridge, GBR) ,  ELLARD John (Sareum Ltd., Cambridge, GBR) ,  PITON Nelly (Sareum Ltd., Cambridge, GBR) ,  TAYLOR Suznne (Sareum Ltd., Cambridge, GBR) ,  CHERRY Michael (Inst. of Cancer Res., Surrey, GBR) ,  FISHER Martin (Sareum Ltd., Cambridge, GBR) ,  BOXALL Kathy (Inst. of Cancer Res., Surrey, GBR) ,  BURNS Samantha (Inst. of Cancer Res., Surrey, GBR) ,  WALTON Michael I. (Inst. of Cancer Res., Surrey, GBR) ,  WESTWOOD Isaac M. (Inst. of Cancer Res., Surrey, GBR) ,  HAYES Angela (Inst. of Cancer Res., Surrey, GBR) ,  EVE Paul (Inst. of Cancer Res., Surrey, GBR) ,  VALENTI Melanie (Inst. of Cancer Res., Surrey, GBR) ,  DE HAVEN BRANDON Alexis (Inst. of Cancer Res., Surrey, GBR) ,  BOX Gary (Inst. of Cancer Res., Surrey, GBR) ,  VAN MONTFORT Rob L. M. (Inst. of Cancer Res., Surrey, GBR) ,  WILLIAMS David H. (Sareum Ltd., Cambridge, GBR) ,  AHERNE G. Wynne (Inst. of Cancer Res., Surrey, GBR) ,  RAYNAUD Florence I. (Inst. of Cancer Res., Surrey, GBR) ,  ECCLES Suzanne A. (Inst. of Cancer Res., Surrey, GBR) ,  GARRETT Michelle D. (Inst. of Cancer Res., Surrey, GBR) ,  COLLINS Ian (Inst. of Cancer Res., Surrey, GBR)
Material： Journal of Medicinal Chemistry  (J Med Chem)
Volume： 54  Issue： 24  Page： 8328-8342  Publication year： Dec. 22, 2011 
JST Material Number： D0102A  ISSN： 0022-2623  CODEN： JMCMAR  Document type： Article
Country of issue： United States (USA)  Language： ENGLISH (EN)

Terms in the title (6)： 足場 ,  モーフィング ,  Chk1 ,  阻害剤 ,  誘導 ,  進化