Art

J-GLOBAL ID：201202215145681700   Reference number：12A1681219

A Versatile Transfection Assay System to Evaluate the Biological Effects of Diverse Industrial Chemicals

さまざまな工業薬品の生体影響を評価するための多用途トランスフェクションアッセイシステム

Author (3)： KOIZUMI Shinji (Dep. of Res. Planning and Coordination, National Inst. of Occupational Safety and Health) ,  OHNO Shotaro (Lab. of Molecular Environmental Health, Dep. of Life and Health Sciences, Fac. of Pharma-Sciences, Teikyo Univ.) ,  OTSUKA Fuminori (Lab. of Molecular Environmental Health, Dep. of Life and Health Sciences, Fac. of Pharma-Sciences, Teikyo Univ.)
Material： Biological and Pharmaceutical Bulletin  (Biological & Pharmaceutical Bulletin)
Volume： 35  Issue： 10  Page： 1691-1696 (J-STAGE)  Publication year： 2012 
JST Material Number： S0989A  ISSN： 0918-6158  CODEN： BPBLEO  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *industrial chemicals ,...
Semi thesaurus term： DNA sequence ,...

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JST classification (3)： Toxicity of chemical substances in general  (GZ02010C) ,  Influence of ectotrophic substances on organisms in general  (EE05010K) ,  Gene manipulation  (EC02050B)

Substance index (6)： 3-Methylcholanthrene ,  4-Dimethylaminoazobenzene ,  1-Naphthylamine ,  Estradiol ,  Dexamethasone ,  o-Tolidine

Reference (15)：

• 1) Otsuka F. Gene expression assay for hazard assessment of chemicals. Ind. Health, 40, 113–120 (2002).
• 2) Koizumi S, Suzuki K, Ogra Y, Yamada H, Otsuka F. Transcriptional activity and regulatory protein binding of metal-responsive elements of the human metallothionein-IIA gene. Eur. J. Biochem., 259, 635–642 (1999).
• 3) Martinez E, Givel F, Wahli W. The estrogen-responsive element as an inducible enhancer: DNA sequence requirements and conversion to a glucocorticoid-responsive element. EMBO J., 6, 3719–3727 (1987).
• 4) Lusska A, Shen E, Whitlock JP Jr. Protein-DNA interactions at a dioxin-responsive enhancer. Analysis of six bona fide DNA-binding sites for the liganded Ah receptor. J. Biol. Chem., 268, 6575–6580 (1993).
• 5) Boonyaratanakornkit V, Melvin V, Prendergast P, Altmann M, Ronfani L, Bianchi ME, Taraseviciene L, Nordeen SK, Allegretto EA, Edwards DP. High-mobility group chromatin proteins 1 and 2 functionally interact with steroid hormone receptors to enhance their DNA binding in vitro and transcriptional activity in mammalian cells. Mol. Cell. Biol., 18, 4471–4487 (1998).

Terms in the title (4)： 工業薬品 ,  生体影響 ,  評価 ,  用途