Art

J-GLOBAL ID：201202220153458364   Reference number：12A1194348

Multipeptide immune response to cancer vaccine IMA901 after single-dose cyclophosphamide associates with longer patient survival

がん:シクロホスファミド単回投与後のがんワクチンIMA901投与では,複数のペプチドに対する免疫応答が患者のより長期間の生存に関連する

Author (40)： WALTER Steffen (Immatics Biotechnologies GmbH, Tuebingen, DEU) ,  WEINSCHENK Toni (Immatics Biotechnologies GmbH, Tuebingen, DEU) ,  MENDRZYK Regina (Immatics Biotechnologies GmbH, Tuebingen, DEU) ,  HILF Norbert (Immatics Biotechnologies GmbH, Tuebingen, DEU) ,  SCHOOR Oliver (Immatics Biotechnologies GmbH, Tuebingen, DEU) ,  FRITSCHE Jens (Immatics Biotechnologies GmbH, Tuebingen, DEU) ,  MAHR Andrea (Immatics Biotechnologies GmbH, Tuebingen, DEU) ,  MAURER Dominik (Immatics Biotechnologies GmbH, Tuebingen, DEU) ,  VASS Verona (Immatics Biotechnologies GmbH, Tuebingen, DEU) ,  TRAUTWEIN Claudia (Immatics Biotechnologies GmbH, Tuebingen, DEU) ,  LEWANDROWSKI Peter (Immatics Biotechnologies GmbH, Tuebingen, DEU) ,  FLOHR Christian (Immatics Biotechnologies GmbH, Tuebingen, DEU) ,  FRISCH Juergen (Immatics Biotechnologies GmbH, Tuebingen, DEU) ,  MAYER-MOKLER Andrea (Immatics Biotechnologies GmbH, Tuebingen, DEU) ,  KIRNER Alexandra (Immatics Biotechnologies GmbH, Tuebingen, DEU) ,  REINHARDT Carsten (Immatics Biotechnologies GmbH, Tuebingen, DEU) ,  SINGH-JASUJA Harpreet (Immatics Biotechnologies GmbH, Tuebingen, DEU) ,  STENZL Arnulf (Eberhard Karls Univ. Tuebingen, Tuebingen, DEU) ,  ZDROJOWY Romuald (Univ. Medicine, Wroclaw, POL) ,  PLUZANSKA Anna (Uniwersytetu Medycznego, Lodz, POL) ,  SZCZYLIK Cezary (Military Inst. of Medicine, Warsaw, POL) ,  STAEHLER Michael (Ludwig Maximilians Univ., Munich, DEU) ,  BRUGGER Wolfram (Schwarzwald-Baar Klinikum and Academic Teaching Hospital of the Univ. Freiburg, Villingen-Schwenningen, DEU) ,  DIETRICH Pierre-Yves (Univ. Hospital of Geneva, Geneva, CHE) ,  POHLA Heike (Ludwig Maximilians Univ., Munich, DEU) ,  POHLA Heike (Helmholtz Center, Munich, DEU) ,  STANCZAK Janusz J (Hospital for Infectious Diseases, Warsaw, POL) ,  BRONTE Vincenzo (Verona Univ. Hospital, Verona, ITA) ,  MANDRUZZATO Susanna (Univ. Padova, Padova, ITA) ,  MANDRUZZATO Susanna (Istituto Di Ricovero e Cura a Carattere Scientifico (IRCCS), Padova, ITA) ,  BIEDERMANN Tilo (Eberhard Karls Univ. Tuebingen, Tuebingen, DEU) ,  PAWELEC Graham (Eberhard Karls Univ. Tuebingen, Tuebingen, DEU) ,  DERHOVANESSIAN Evelyna (Eberhard Karls Univ. Tuebingen, Tuebingen, DEU) ,  YAMAGISHI Hisakazu (Kyoto Prefectural Univ. Medicine, Kyoto, JPN) ,  MIKI Tsuneharu (Kyoto Prefectural Univ. Medicine, Kyoto, JPN) ,  HONGO Fumiya (Kyoto Prefectural Univ. Medicine, Kyoto, JPN) ,  TAKAHA Natsuki (Kyoto Prefectural Univ. Medicine, Kyoto, JPN) ,  HIRAKAWA Kosei (Osaka City Univ., Osaka, JPN) ,  TANAKA Hiroaki (Osaka City Univ., Osaka, JPN) ,  STEVANOVIC Stefan (Eberhard Karls Univ. Tuebingen, Tuebingen, DEU)
Material： Nature Medicine  (Nat Med)
Volume： 18  Issue： 8  Page： 1254-1261  Publication year： Aug. 2012 
JST Material Number： W0636A  ISSN： 1078-8956  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Thesaurus term： *antineoplastic alkylating agent ,  single administration ,  *tumor vaccine ,  Prognosis ,  *inactivated vaccine ,  *renal cell carcinoma ,  HLA-A ,  phase 1 study ,  DNA binding protein ,  transcription factor ,  *apo A-I ,  *chemokine ,  *biomarker ,  human ,  amine ,  nitrogen heterocyclic compound ,  oxygen heterocyclic compound ,  organochlorine compound ,  inorganic acid ester ,  phosphorus heterocyclic compound ,  cell response ,  FoxP3 ,  *CCL17 ,  immune response ,  Cell Physiological Phenomena ,  *Vaccines, Subunit
Semi thesaurus term： immunological reaction ,  cell physiology ,  long-term survival ,  *IMA901 ,  *peptide vaccine ,  *prognostic marker

JST classification (3)： Drug therapy(=pharmacotherapy)for tumors  (GE03032C) ,  Urogenital tumors(=neoplasms)  (GM04000S) ,  Cytokines  (EB08090G)

Substance index (1)： Cyclophosphamid

Terms in the title (10)： がん ,  シクロホスファミド ,  単回投与 ,  がんワクチン ,  投与 ,  ペプチド ,  免疫応答 ,  患者 ,  長期間 ,  生存