Art

J-GLOBAL ID：201202221121148157   Reference number：12A0944452

The molecular evolution of acquired resistance to targeted EGFR blockade in colorectal cancers

大腸がんでの分子標的薬によるEGFR遮断に対する獲得耐性の分子進化

Author (16)： DIAZ Luis A., Jr (Howard Hughes Medical Inst. at Johns Hopkins Kimmel Cancer Center, Maryland, USA) ,  WU Jian (Howard Hughes Medical Inst. at Johns Hopkins Kimmel Cancer Center, Maryland, USA) ,  KINDE Isaac (Howard Hughes Medical Inst. at Johns Hopkins Kimmel Cancer Center, Maryland, USA) ,  KINZLER Kenneth W. (Howard Hughes Medical Inst. at Johns Hopkins Kimmel Cancer Center, Maryland, USA) ,  VOGELSTEIN Bert (Howard Hughes Medical Inst. at Johns Hopkins Kimmel Cancer Center, Maryland, USA) ,  DIAZ Luis A., Jr (Swim Across America Lab. at Johns Hopkins, Maryland, USA) ,  WILLIAMS Richard T. (Amgen Inc., California, USA) ,  OLINER Kelly S. (Amgen Inc., California, USA) ,  WU Jian (Fourth Military Medical Univ., Xi’an, CHN) ,  HECHT J. Randolph (Univ. California, Los Angeles, California, USA) ,  BERLIN Jordan (Vanderbilt Univ. Medical Center, Tennessee, USA) ,  ALLEN Benjamin (Harvard Univ., Massachusetts, USA) ,  BOZIC Ivana (Harvard Univ., Massachusetts, USA) ,  REITER Johannes G. (Harvard Univ., Massachusetts, USA) ,  NOWAK Martin A. (Harvard Univ., Massachusetts, USA) ,  REITER Johannes G. (IST Austria (Inst. of Sci. and Technol. Austria), Klosterneuburg, AUT)
Material： Nature (London)  (Nature (Lond))
Volume： 486  Issue： 7404  Page： 537-540  Publication year： Jun. 28, 2012 
JST Material Number： D0193B  ISSN： 0028-0836  Document type： Article
Article type： 原著論文  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Thesaurus term： EGF receptor ,  colorectal neoplasm ,  enzyme inhibitor ,  antitumor drug ,  human(primates) ,  monoclonal antibody ,  *molecular targeting drug ,  drug resistance ,  molecular evolution ,  *ras gene ,  mathematical model ,  mutation ,  mutagenesis
Semi thesaurus term： *K-ras gene ,  Panitumumab

JST classification (2)： Basic research of antitumor(=antineoplastic)drugs  (GW16010A) ,  Genetic variation  (EC01030Y)

Terms in the title (7)： 大腸がん ,  分子標的薬 ,  EGFR ,  遮断 ,  獲得 ,  耐性 ,  分子進化