Art

J-GLOBAL ID：201202232901184440   Reference number：12A0042743

Detection of β cell death in diabetes using differentially methylated circulating DNA

異なってメチル化された循環DNAを用いた糖尿病でのβ細胞死の検出

Author (8)： AKIRAV Eitan M. (Yale Univ. School of Medicine, CT) ,  LEBASTCHI Jasmin (Yale Univ. School of Medicine, CT) ,  GALVAN Eva M. (Yale Univ. School of Medicine, CT) ,  HENEGARIU Octavian (Yale Univ. School of Medicine, CT) ,  AKIRAV Michael (Bar-Ilan Univ., Ramat Gan, ISR) ,  ABLAMUNITS Vitaly (Yale Univ. School of Medicine, CT) ,  LIZARDI Paul M. (Yale Univ. School of Medicine, CT) ,  HEROLD Kevan C. (Yale Univ. School of Medicine, CT)
Material： Proceedings of the National Academy of Sciences of the United States of America  (PNAS)
Volume： 108  Issue： 47  Page： 19018-19023  Publication year： Nov. 22, 2011 
JST Material Number： D0387A  ISSN： 0027-8424  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Thesaurus term： *Methylation ,  *Diabetes Mellitus ,  endocrine cell ,  *Cell Death ,  *hyperglycemia ,  Early Diagnosis ,  in vivo experiment ,  *gene ,  experimental disease ,  *demethylation ,  Mus musculus ,  laboratory animal ,  pathogenesis ,  *type 1 diabetes mellitus ,  insulin ,  *DNA Methylation ,  *insulin gene ,  Insulin-Secreting Cells ,  NOD mice ,  Myomorpha ,  hypoglycemic drug ,  metabolic drug ,  carbohydrate metabolic drug ,  drug
Semi thesaurus term： *insulin-dependend diabetes mellitus ,  insulin ,  pancreatic beta-cell ,  Streptozotocin-Induced Diabetes ,  non-obese diabetic mice

JST classification (2)： Metabolic diseases,nutritional diseases in general.  (GD05010J) ,  Gene expression  (EC02040Q)

Terms in the title (5)： メチル化 ,  循環 ,  DNA ,  糖尿病 ,  細胞死