Art

J-GLOBAL ID：201202236047248869   Reference number：12A1188475

Discovery of N-(4-methoxy-7-methylbenzo[d]thiazol-2-yl)isonicatinamide, ML293, as a novel, selective and brain penetrant positive allosteric modulator of the muscarinic 4 (M₄) receptor

ムスカリン4(M₄)受容体の新しく、選択的で、脳浸透性のpositive allosteric modulatorとしてのN-(4-メトオキシ-7-メチルベンゾ[d]チアゾール-2-yl)イソニコチンアミド,ML293の発見

Author (40)： SALOVICH James M. (Dep. of Pharmacology, Vanderbilt Univ. Medical Center, Nashville, TN 37232, USA) ,  SALOVICH James M. (Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt Univ. Medical Center, Nashville, TN 37232, USA) ,  SALOVICH James M. (Vanderbilt Specialized Chemistry Center for Probe Dev. (MLPCN), Nashville, TN 37232, USA) ,  VINSON Paige N. (Dep. of Pharmacology, Vanderbilt Univ. Medical Center, Nashville, TN 37232, USA) ,  VINSON Paige N. (Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt Univ. Medical Center, Nashville, TN 37232, USA) ,  VINSON Paige N. (Vanderbilt Specialized Chemistry Center for Probe Dev. (MLPCN), Nashville, TN 37232, USA) ,  SHEFFLER Douglas J. (Dep. of Pharmacology, Vanderbilt Univ. Medical Center, Nashville, TN 37232, USA) ,  SHEFFLER Douglas J. (Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt Univ. Medical Center, Nashville, TN 37232, USA) ,  SHEFFLER Douglas J. (Vanderbilt Specialized Chemistry Center for Probe Dev. (MLPCN), Nashville, TN 37232, USA) ,  LAMSAL Atin (Dep. of Pharmacology, Vanderbilt Univ. Medical Center, Nashville, TN 37232, USA) ,  LAMSAL Atin (Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt Univ. Medical Center, Nashville, TN 37232, USA) ,  LAMSAL Atin (Vanderbilt Specialized Chemistry Center for Probe Dev. (MLPCN), Nashville, TN 37232, USA) ,  UTLEY Thomas J. (Dep. of Pharmacology, Vanderbilt Univ. Medical Center, Nashville, TN 37232, USA) ,  UTLEY Thomas J. (Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt Univ. Medical Center, Nashville, TN 37232, USA) ,  UTLEY Thomas J. (Vanderbilt Specialized Chemistry Center for Probe Dev. (MLPCN), Nashville, TN 37232, USA) ,  BLOBAUM Anna L. (Dep. of Pharmacology, Vanderbilt Univ. Medical Center, Nashville, TN 37232, USA) ,  BLOBAUM Anna L. (Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt Univ. Medical Center, Nashville, TN 37232, USA) ,  BLOBAUM Anna L. (Vanderbilt Specialized Chemistry Center for Probe Dev. (MLPCN), Nashville, TN 37232, USA) ,  BRIDGES Thomas M. (Dep. of Pharmacology, Vanderbilt Univ. Medical Center, Nashville, TN 37232, USA) ,  BRIDGES Thomas M. (Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt Univ. Medical Center, Nashville, TN 37232, USA) ,  BRIDGES Thomas M. (Vanderbilt Specialized Chemistry Center for Probe Dev. (MLPCN), Nashville, TN 37232, USA) ,  LE Uyen (Dep. of Pharmacology, Vanderbilt Univ. Medical Center, Nashville, TN 37232, USA) ,  LE Uyen (Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt Univ. Medical Center, Nashville, TN 37232, USA) ,  LE Uyen (Vanderbilt Specialized Chemistry Center for Probe Dev. (MLPCN), Nashville, TN 37232, USA) ,  JONES Carrie K. (Dep. of Pharmacology, Vanderbilt Univ. Medical Center, Nashville, TN 37232, USA) ,  JONES Carrie K. (Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt Univ. Medical Center, Nashville, TN 37232, USA) ,  JONES Carrie K. (Vanderbilt Specialized Chemistry Center for Probe Dev. (MLPCN), Nashville, TN 37232, USA) ,  JONES Carrie K. (US Dep. of Veterans Affairs, Tennessee Valley Healthcare System, Nashville, TN 37232, USA) ,  WOOD Michael R. (Dep. of Pharmacology, Vanderbilt Univ. Medical Center, Nashville, TN 37232, USA) ,  WOOD Michael R. (Dep. of Chemistry, Vanderbilt Univ., Nashville, TN 37232, USA) ,  WOOD Michael R. (Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt Univ. Medical Center, Nashville, TN 37232, USA) ,  WOOD Michael R. (Vanderbilt Specialized Chemistry Center for Probe Dev. (MLPCN), Nashville, TN 37232, USA) ,  SCOTT DANIELS J. (Dep. of Pharmacology, Vanderbilt Univ. Medical Center, Nashville, TN 37232, USA) ,  SCOTT DANIELS J. (Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt Univ. Medical Center, Nashville, TN 37232, USA) ,  SCOTT DANIELS J. (Vanderbilt Specialized Chemistry Center for Probe Dev. (MLPCN), Nashville, TN 37232, USA) ,  JEFFREY CONN P. (Dep. of Pharmacology, Vanderbilt Univ. Medical Center, Nashville, TN 37232, USA) ,  JEFFREY CONN P. (Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt Univ. Medical Center, Nashville, TN 37232, USA) ,  JEFFREY CONN P. (Vanderbilt Specialized Chemistry Center for Probe Dev. (MLPCN), Nashville, TN 37232, USA) ,  NISWENDER Colleen M. (Dep. of Pharmacology, Vanderbilt Univ. Medical Center, Nashville, TN 37232, USA) ,  NISWENDER Colleen M. (Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt Univ. Medical Center, Nashville, TN 37232, USA)
Material： Bioorganic & Medicinal Chemistry Letters  (Bioorg Med Chem Lett)
Volume： 22  Issue： 15  Page： 5084-5088  Publication year： Aug. 01, 2012 
JST Material Number： W0248A  ISSN： 0960-894X  Document type： Article
Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Terms in the title (7)： ムスカリン ,  受容体 ,  脳 ,  浸透性 ,  チアゾール ,  イソニコチンアミド ,  発見