Art

J-GLOBAL ID：201202241314006270   Reference number：12A0638483

Vitamin E decreases bone mass by stimulating osteoclast fusion

骨粗鬆症:ビタミンEは破骨細胞の融合を促進し,骨量を減少させる

Author (18)： FUJITA Koji (Tokyo Medical and Dental Univ., Tokyo, JPN) ,  IWASAKI Makiko (Tokyo Medical and Dental Univ., Tokyo, JPN) ,  MA Chengshan (Tokyo Medical and Dental Univ., Tokyo, JPN) ,  SHINOMIYA Kenichi (Tokyo Medical and Dental Univ., Tokyo, JPN) ,  OKAWA Atsushi (Tokyo Medical and Dental Univ., Tokyo, JPN) ,  OCHI Hiroki (Keio Univ., Tokyo, JPN) ,  FUKUDA Toru (Keio Univ., Tokyo, JPN) ,  SUNAMURA Satoko (Keio Univ., Tokyo, JPN) ,  ITOH Hiroshi (Keio Univ., Tokyo, JPN) ,  TAKEDA Shu (Keio Univ., Tokyo, JPN) ,  MIYAMOTO Takeshi (Keio Univ., Tokyo, JPN) ,  TAKITANI Kimitaka (Osaka Medical Coll., Osaka, JPN) ,  TAMAI Hiroshi (Osaka Medical Coll., Osaka, JPN) ,  NEGISHI-KOGA Takako (Tokyo Medical and Dental Univ., Tokyo, JPN) ,  TAKAYANAGI Hiroshi (Tokyo Medical and Dental Univ., Tokyo, JPN) ,  KODAMA Tatsuhiko (Univ. Tokyo, Tokyo, JPN) ,  KATO Shigeaki (Univ. Tokyo, Tokyo, JPN) ,  ARAI Hiroyuki (Univ. Tokyo, Tokyo, JPN)
Material： Nature Medicine  (Nat Med)
Volume： 18  Issue： 4  Page： 589-594  Publication year： Apr. 2012 
JST Material Number： W0636A  ISSN： 1078-8956  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Thesaurus term： *osteoporosis ,  *vitamin E ,  osteoclast ,  Cell Fusion ,  *Bone Density ,  *osteoblast ,  *osteogenesis ,  cell ,  vitamin D ,  *homeostasis ,  Mus musculus ,  Vitamin E Deficiency ,  Proteins ,  antioxidation ,  transmembrane protein ,  p38 MAP kinase ,  DNA binding protein ,  transcription factor ,  promoter (genetics) ,  gene introduction ,  wild type ,  dietary supplement ,  Rattus ,  phenolic compound ,  oxygen heterocyclic compound ,  polynuclear aromatic compound ,  DC-STAMP ,  Mitogen-Activated Protein Kinase 14 ,  osteoclast precursor ,  syncytia ,  *Bone Remodeling ,  Carrier Proteins ,  Microphthalmia-Associated Transcription Factor ,  Myomorpha
Semi thesaurus term： osteoclast precursor ,  apocyte ,  *Bone Remodeling ,  Carrier Proteins ,  MITF

JST classification (2)： Basic medicine on musculoskeletal system  (GG01020B) ,  Vitamin E  (EB07060S)

Substance index (1)： alpha-Tocopherol

Terms in the title (6)： 骨粗鬆症 ,  ビタミンE ,  破骨細胞 ,  融合 ,  促進 ,  骨量