Art

J-GLOBAL ID：201202248089533065   Reference number：12A1050770

Down-Regulation of Myosin Light Chain Kinase Expression in Vascular Smooth Muscle Cells Accelerates Cell Proliferation: Requirement of Its Actin-binding Domain for Reversion to Normal Rates

血管平滑筋細胞におけるミオシン軽鎖キナーゼ発現のダウンレギュレーションは細胞増殖を加速する:正常速度への反転に対する,そのアクチン結合ドメインの必要性

Author (9)： WANG Hong Hui (Dep. of Molecular and Cellular Pharmacology, Gunma Univ. Graduate School of Medicine, JPN) ,  NAKAMURA Akio (Dep. of Molecular and Cellular Pharmacology, Gunma Univ. Graduate School of Medicine, JPN) ,  YOSHIYAMA Shinji (Dep. of Molecular and Cellular Pharmacology, Gunma Univ. Graduate School of Medicine, JPN) ,  ISHIKAWA Ryoki (Dep. of Molecular and Cellular Pharmacology, Gunma Univ. Graduate School of Medicine, JPN) ,  CAI Na (Dep. of Biochemistry, Coll. of Life Sciences, Nankai Univ., P.R. China) ,  YE Li-hong (Dep. of Biochemistry, Coll. of Life Sciences, Nankai Univ., P.R. China) ,  TAKANO-OHMURO Hiromi (Res. Inst. of Pharmaceutical Sciences, Musashino Univ., JPN) ,  KOHAMA Kazuhiro (Dep. of Molecular and Cellular Pharmacology, Gunma Univ. Graduate School of Medicine, JPN) ,  KOHAMA Kazuhiro (Res. Inst. of Pharmaceutical Sciences, Musashino Univ., JPN)
Material： Journal of Pharmacological Sciences  (J Pharmacol Sci)
Volume： 119  Issue： 1  Page： 91-96 (J-STAGE)  Publication year： 2012 
JST Material Number： G0813A  ISSN： 1347-8613  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *vascular smooth muscle cell ,...

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JST classification (3)： Basic medicine on cardiovascular system  (GJ01020K) ,  Biological function  (EB03040U) ,  Cell physiology in general  (EF02010S)

Reference (15)：

• 1 Kamm KE, Stull JT. Dedicated myosin light chain kinases with diverse cellular functions. J Biol Chem. 2001;276:4527–4530.
• 2 Nakamura A, Xie C, Zhang Y, Gao Y, Wang HH, Ye LH, et al. Role of non-kinase activity of myosin light-chain kinase in regulating smooth muscle contraction, a review dedicated to Dr. Setsuro Ebashi. Biochem Biophys Res Commun. 2008;369:135–143.
• 3 Robinson DN, Spudich JA. Towards a molecular understanding of cytokinesis. Trends Cell Biol. 2000;10:228–237.
• 4 Batchelder EL, Thomas-Virnig CL, Hardin JD, White JG. Cytokinesis is not controlled by calmodulin or myosin light chain kinase in the Caenorhabditis elegans early embryo. FEBS Lett. 2007;581:4337–4341.
• 5 Kishi H, Mikawa T, Seto M, Sasaki Y, Kanayasu-Toyoda T, Yamaguchi T, et al. Stable transfectants of smooth muscle cell line lacking the expression of myosin light chain kinase and their characterization with respect to the actomyosin system. J Biol Chem. 2000;275:1414–1420.

Terms in the title (9)： 血管平滑筋細胞 ,  ミオシン軽鎖キナーゼ ,  発現 ,  ダウンレギュレーション ,  細胞増殖 ,  加速 ,  反転 ,  アクチン ,  結合ドメイン