Art

J-GLOBAL ID：201202251645987764   Reference number：12A0616904

Microarray and gene ontology analyses reveal downregulation of DNA repair and apoptotic pathways in diethylstilbestrol-exposed testicular Leydig cells

マイクロアレイ及び遺伝子オントロジー解析はジエチルスチルベストロール曝露精巣Leydig細胞においてDNA修復及びアポトーシス経路のダウンレギュレーションを示す

Author (9)： WARITA Katsuhiko (Dep. of Anatomy and Neurobiology, Fac. of Medicine, Kagawa Univ.) ,  WARITA Katsuhiko (Departments of Pathology and Human Genetics, Univ. of Pittsburgh Medical Center) ,  MITSUHASHI Tomoko (Departments of Pathology and Human Genetics, Univ. of Pittsburgh Medical Center) ,  TABUCHI Yoshiaki (Div. of Molecular Genetics Res., Life Sci. Res. Center, Univ. of Toyama) ,  OHTA Ken-ichi (Dep. of Anatomy and Neurobiology, Fac. of Medicine, Kagawa Univ.) ,  SUZUKI Shingo (Dep. of Anatomy and Neurobiology, Fac. of Medicine, Kagawa Univ.) ,  HOSHI Nobuhiko (Dep. of Bioresource Sci., Graduate School of Agricultural Sci., Kobe Univ.) ,  MIKI Takanori (Dep. of Anatomy and Neurobiology, Fac. of Medicine, Kagawa Univ.) ,  TAKEUCHI Yoshiki (Dep. of Anatomy and Neurobiology, Fac. of Medicine, Kagawa Univ.)
Material： Journal of Toxicological Sciences  (J Toxicol Sci)
Volume： 37  Issue： 2  Page： 287-295 (J-STAGE)  Publication year： 2012 
JST Material Number： Z0265B  ISSN： 0388-1350  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *DNA microarray ,...
Semi thesaurus term： TIA-1 ,...

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JST classification (3)： Molecular genetics in general  (EC02010J) ,  Sex hormones  (EB08050O) ,  Carcinogenic mechanisms and factors  (GE02020C)

Substance index (2)： Estradiol ,  Diethylstilbestrol

Reference (27)：

• Ashburner, M., Ball, C.A., Blake, J.A., Botstein, D., Butler, H., Cherry, J.M., Davis, A.P., Dolinski, K., Dwight, S.S., Eppig, J.T., Harris, M.A., Hill, D.P., Issel-Tarver, L., Kasarskis, A., Lewis, S., Matese, J.C., Richardson, J.E., Ringwald, M., Rubin, G.M. and Sherlock, G. (2000): Gene ontology: tool for the unification of biology. The Gene Ontology Consortium. Nat. Genet., 25, 25-29.
• Deshmukh, A.S. and Hartung, W.H. (1983): Leydig cell tumor in patient on estrogen therapy. Urology, 21, 538-539.
• DuMond, J.W. and Roy, D. (2001): The inhibition of DNA repair capacity by stilbene estrogen in Leydig cells: its implications in the induction of instability in the testicular genome. Mutat. Res., 483, 27-33.
• Fisher, J.S., Millar, M.R., Majdic, G., Saunders, P.T., Fraser, H.M. and Sharpe, R.M. (1997): Immunolocalisation of oestrogen receptor-α (ERα) within the testis and excurrent ducts of the rat and marmoset monkey from perinatal life to adulthood. J. Endocrinol., 153, 485-495.
• Fowler, K.A., Gill, K., Kirma, N., Dillehay, D.L. and Tekmal, R.R. (2000): Overexpression of aromatase leads to development of testicular Leydig cell tumors: an in vivo model for hormone-mediated testicular cancer. Am. J. Pathol., 156, 347-353.

Terms in the title (11)： マイクロアレイ ,  遺伝子オントロジー ,  解析 ,  ジエチルスチルベストロール ,  曝露 ,  精巣 ,  Leydig細胞 ,  DNA修復 ,  アポトーシス ,  経路 ,  ダウンレギュレーション