Art

J-GLOBAL ID：201202256250458020   Reference number：12A1065716

Synthesis and functional evaluation of chiral dendrimer-triamine-coordinated Gd complexes as highly sensitive MRI contrast agents

高感度MRI造影剤としてのキラルなデンドリマ-トリアミン-配位Gd錯体の合成および機能評価

Author (13)： MIYAKE Yuka (Dep. of Energy and Hydrocarbon Chemistry, Graduate School of Engineering, Kyoto Univ., Nishikyo-ku, Kyoto 615-8510, JPN) ,  KIMURA Yu (Advanced Biomedical Engineering Res. Unit, Kyoto Univ., Nishikyo-ku, Kyoto 615-8510, JPN) ,  ISHIKAWA Syungo (Dep. of Energy and Hydrocarbon Chemistry, Graduate School of Engineering, Kyoto Univ., Nishikyo-ku, Kyoto 615-8510, JPN) ,  TSUJITA Hiroshi (Dep. of Energy and Hydrocarbon Chemistry, Graduate School of Engineering, Kyoto Univ., Nishikyo-ku, Kyoto 615-8510, JPN) ,  MIURA Hiroki (Dep. of Energy and Hydrocarbon Chemistry, Graduate School of Engineering, Kyoto Univ., Nishikyo-ku, Kyoto 615-8510, JPN) ,  NARAZAKI Michiko (Graduate School of Informatics, Kyoto Univ., Yoshida-honmachi, Sakyo-ku, Kyoto 606-8501, JPN) ,  MATSUDA Tetsuya (Graduate School of Informatics, Kyoto Univ., Yoshida-honmachi, Sakyo-ku, Kyoto 606-8501, JPN) ,  TABATA Yasuhiko (Inst. for Frontier Medical Sciences, Kyoto Univ., 53 Kawaracho, Shogoin, Sakyo-ku 606-8507, JPN) ,  YANO Tetsuya (Canon Inc., 3-30-2 Shimomaruko, Ohta-ku, Tokyo 146-8501, JPN) ,  TOSHIMITSU Akio (Dep. of Energy and Hydrocarbon Chemistry, Graduate School of Engineering, Kyoto Univ., Nishikyo-ku, Kyoto 615-8510, JPN) ,  TOSHIMITSU Akio (Inst. for Chemical Res., Kyoto Univ., Gokasho, Uji, Kyoto 611-0011, JPN) ,  KONDO Teruyuki (Dep. of Energy and Hydrocarbon Chemistry, Graduate School of Engineering, Kyoto Univ., Nishikyo-ku, Kyoto 615-8510, JPN) ,  KONDO Teruyuki (Advanced Biomedical Engineering Res. Unit, Kyoto Univ., Nishikyo-ku, Kyoto 615-8510, JPN)
Material： Tetrahedron Letters  (Tetrahedron Lett)
Volume： 53  Issue： 34  Page： 4580-4583  Publication year： Aug. 22, 2012 
JST Material Number： E0366A  ISSN： 0040-4039  Document type： Article
Article type： 短報  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Thesaurus term： contrast media ,  *dendrimer ,  polyamine ,  *gadolinium complex ,  chemical synthesis ,  pharmacokinetics ,  drug design ,  aliphatic amine ,  aliphatic carboxylic acid ,  diamine ,  tertiary amine
Semi thesaurus term： MRI contrast media ,  function assessment

JST classification (2)： Complexes of 3 group  (CE01060J) ,  Atomic and molecular clusters  (BH09030O)

Substance index (5)： 4-(Chloromethyl)styrene ,  DTPA ,  DOTA ,  1,4,7-Tris[4-[(R)-1,2-bis[4-[(R)-1,2-dihydroxyethyl]benzyloxy]ethyl]benzyl]-1,4,7-triazacyclononane ,  1,4,7-Tris[4-[(1S)-1,2-bis[4-[(1S)-1,2-dihydroxyethyl]benzyloxy]ethyl]benzyl]-1,4,7-triazacyclononane

Terms in the title (9)： 高感度 ,  MRI造影剤 ,  キラル ,  デンドリマ ,  トリ ,  アミン ,  Gd ,  錯体 ,  機能評価