Art

J-GLOBAL ID：201202260761176888   Reference number：12A0437031

A Differentiation Checkpoint Limits Hematopoietic Stem Cell Self-Renewal in Response to DNA Damage

分化チェックポイントはDNA損傷に反応した造血幹細胞自己再生を制限する

Author (24)： WANG Jianwei (Inst. of Molecular Medicine and Max-Planck-Research Dep. of Stem Cell Aging, Univ. of Ulm, 89069 Ulm, DEU) ,  SUN Qian (Inst. of Molecular Medicine and Max-Planck-Research Dep. of Stem Cell Aging, Univ. of Ulm, 89069 Ulm, DEU) ,  MORITA Yohei (Inst. of Molecular Medicine and Max-Planck-Research Dep. of Stem Cell Aging, Univ. of Ulm, 89069 Ulm, DEU) ,  JIANG Hong (Inst. of Molecular Medicine and Max-Planck-Research Dep. of Stem Cell Aging, Univ. of Ulm, 89069 Ulm, DEU) ,  GROSS Alexander (Res. Group Bioinformatics and Systems Biology, Inst. of Neural Information Processing, Univ. of Ulm, 89069 Ulm, DEU) ,  LECHEL Andre (Inst. of Molecular Medicine and Max-Planck-Research Dep. of Stem Cell Aging, Univ. of Ulm, 89069 Ulm, DEU) ,  HILDNER Kai (Dep. of Medicine 1, Max Eder Res. Group, Univ. of Erlangen-Nuernberg, 91054 Erlangen, DEU) ,  GUACHALLA Luis Miguel (Inst. of Molecular Medicine and Max-Planck-Research Dep. of Stem Cell Aging, Univ. of Ulm, 89069 Ulm, DEU) ,  GOMPF Anne (Inst. of Molecular Medicine and Max-Planck-Research Dep. of Stem Cell Aging, Univ. of Ulm, 89069 Ulm, DEU) ,  HARTMANN Daniel (Inst. of Molecular Medicine and Max-Planck-Research Dep. of Stem Cell Aging, Univ. of Ulm, 89069 Ulm, DEU) ,  SCHAMBACH Axel (Inst. of Experimental Hematology, Hannover Medical School, 30625 Hannover, DEU) ,  WUESTEFELD Torsten (Helmholtz Center for Infection Res., 38124 Braunschweig, DEU) ,  WUESTEFELD Torsten (Dep. of Gastroenterology, Hepatology, and Endocrinology, Hannover Medical School, 30625 Hannover, DEU) ,  DAUCH Daniel (Helmholtz Center for Infection Res., 38124 Braunschweig, DEU) ,  DAUCH Daniel (Dep. of Gastroenterology, Hepatology, and Endocrinology, Hannover Medical School, 30625 Hannover, DEU) ,  SCHREZENMEIER Hubert (Inst. for Clinical Transfusion Medicine and Immunogenetics, Univ. of Ulm, 89069 Ulm, DEU) ,  SCHREZENMEIER Hubert (German Red Cross Blood Transfusion Serv. Baden-Wurttemberg-Hessen, D-76530 Baden, DEU) ,  HOFMANN Wolf-karsten (Dep. of Hematology and Oncology, Mannheim Univ. Hospital, 68167 Mannheim, DEU) ,  NAKAUCHI Hiromitsu (Guest Professorship Univ. of Ulm, Germany, Centre for Stem Cell Biology and Regenerative Medicine, Inst. of Medical ...) ,  JU Zhenyu (Inst. of Aging Res., Hangzhou Normal Univ. Coll. of Medicine, Hangzhou, CHN) ,  KESTLER Hans A. (Res. Group Bioinformatics and Systems Biology, Inst. of Neural Information Processing, Univ. of Ulm, 89069 Ulm, DEU) ,  ZENDER Lars (Helmholtz Center for Infection Res., 38124 Braunschweig, DEU) ,  ZENDER Lars (Dep. of Gastroenterology, Hepatology, and Endocrinology, Hannover Medical School, 30625 Hannover, DEU) ,  RUDOLPH K. Lenhard (Inst. of Molecular Medicine and Max-Planck-Research Dep. of Stem Cell Aging, Univ. of Ulm, 89069 Ulm, DEU)
Material： Cell (Cambridge, Mass.)  (Cell (Camb. Mass.))
Volume： 148  Issue： 5  Page： 1001-1014  Publication year： Mar. 02, 2012 
JST Material Number： A0707B  ISSN： 0092-8674  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Thesaurus term： *hematopoietic stem cell ,  *DNA lesion ,  *Cell Differentiation ,  Regeneration ,  gamma-ray irradiation ,  telomere ,  DNA binding protein ,  transcription factor ,  knockout mouse ,  G-CSF ,  STAT transcription factor ,  senile change ,  interleukin receptor ,  mathematical model ,  myelodysplastic syndrome ,  human ,  Bone Marrow ,  *DNA-damage checkpoint ,  STAT3 Transcription Factor ,  IL7 receptor ,  *differentiation (biology) ,  *developmental physiology ,  laboratory animal ,  Mus musculus
Semi thesaurus term： self-renewing ,  BSTF ,  STAT3 ,  Receptors, Interleukin-7

JST classification (4)： Cell physiology in general  (EF02010S) ,  Hematopoietic system  (EJ07020Y) ,  Biological function  (EB03040U) ,  Aging and death  (EJ16040S)

Terms in the title (6)： 分化 ,  チェックポイント ,  DNA損傷 ,  造血幹細胞 ,  自己再生 ,  制限