Art

J-GLOBAL ID：201202261827745001   Reference number：12A0380681

The same pocket in menin binds both MLL and JUND but has opposite effects on transcription

MLLとJUNDはともにメニンの同じポケットに結合するが,転写には逆の影響を与える

Author (9)： HUANG Jing (Univ. Michigan Medical School, Michigan, USA) ,  WAN Bingbing (Univ. Michigan Medical School, Michigan, USA) ,  WAN Ke (Univ. Michigan Medical School, Michigan, USA) ,  LEI Ming (Univ. Michigan Medical School, Michigan, USA) ,  GURUNG Buddha (Univ. Pennsylvania Perelman School of Medicine, Pennsylvania, USA) ,  MATKAR Smita (Univ. Pennsylvania Perelman School of Medicine, Pennsylvania, USA) ,  HUA Xianxin (Univ. Pennsylvania Perelman School of Medicine, Pennsylvania, USA) ,  VENIAMINOVA Natalia A. (Univ. Michigan, Michigan, USA) ,  MERCHANT Juanita L. (Univ. Michigan, Michigan, USA)
Material： Nature (London)  (Nature (Lond))
Volume： 482  Issue： 7386  Page： 542-546  Publication year： Feb. 23, 2012 
JST Material Number： D0193B  ISSN： 0028-0836  Document type： Article
Article type： 原著論文  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Thesaurus term： *transcription factor ,  tumor suppressor protein ,  JNK MAP kinase ,  protein complex ,  crystal structure ,  tertiary structure ,  X-Ray Diffraction ,  *protein methyltransferase ,  histone ,  Leukemia ,  *JunD ,  *MLL1 ,  histone H3 ,  menin ,  transcription control ,  Gene Expression Regulation ,  p75 ,  Heredity
Semi thesaurus term： genetic regulation ,  LEDGF

JST classification (3)： Carcinogenic mechanisms and factors  (GE02020C) ,  Gene expression  (EC02040Q) ,  Molecular structure  (EB03020Y)

Terms in the title (3)： JunD ,  メニン ,  転写