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J-GLOBAL ID：201202267434406653   Reference number：12A0394566

Pharmacogenomics of CYP2D6: Molecular Genetics, Interethnic Differences and Clinical Importance

CYP2D6の薬理ゲノミクス:分子遺伝学,民族差および臨床的重要性

Author (2)： TEH Lay Kek (Pharmacogenomics Centre (PROMISE), Fac. of Pharmacy, Universiti Teknologi MARA) ,  BERTILSSON Leif (Div. of Clinical Pharmacology, Dep. of Lab. Medicine, Karolinska Univ., Hospital-Huddinge, Karolinska Institutet)
Material： Drug Metabolism and Pharmacokinetics  (Drug Metab Pharmacokinet)
Volume： 27  Issue： 1  Page： 55-67 (J-STAGE)  Publication year： 2012 
JST Material Number： X0758A  ISSN： 1347-4367  Document type： Article
Article type： 文献レビュー  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： human(primates) ,...
Semi thesaurus term： *CYP2D6 ,...

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JST classification (1)： Pharmacology in general  (GW01000B)

Reference (160)：

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• 2) Kroemer, H. K. and Eichelbaum, M.: “It's the genes, stupid”. Molecular bases and clinical consequences of genetic cytochrome P450 2D6 polymorphism. Life Sci., 56: 2285–2298 (1995).
• 3) Linder, M. W., Prough, R. A. and Valdes, R., Jr.: Pharmacogenetics: a laboratory tool for optimizing therapeutic efficiency. Clin. Chem., 43: 254–266 (1997).
• 4) Pelkonen, O. and Breimer, D. D.: Role of environmental factors in the pharmacokinetics of drugs: Considerations with respect to animal models, P-450 enzymes, and probe drugs. Handb. Exp. Pharmacol., 110: 289–332 (1994).
• 5) Shimada, T., Yamazaki, H., Mimura, M., Inui, Y. and Guengerich, F. P.: Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians. J. Pharmacol. Exp. Ther., 270: 414–423 (1994).

Terms in the title (6)： CYP2D6 ,  薬理ゲノミクス ,  分子遺伝学 ,  民族差 ,  臨床 ,  重要性