Art

J-GLOBAL ID：201202268060303754   Reference number：12A0534251

A Simple and Rapid HPLC Method for the Determination of Mitotane in Human Plasma and its Application to a Patient

HPLCによる簡便なミトタン血中濃度測定法の開発および適用

Author (7)： UCHIYAMA MASANOBU (福岡大 病院 薬剤部) ,  HARA SHUJI (福岡大 薬) ,  OGATA KENTARO (福岡大 病院 薬剤部) ,  IMAMURA TAKESHI (福岡大 病院 薬剤部) ,  TAKAMATSU YASUSHI (福岡大 医 腫瘍・血液・感染症内科学) ,  TAMURA KAZUO (福岡大 医 腫瘍・血液・感染症内科学) ,  FUTAGAMI KOJIRO (福岡大 病院 薬剤部)
Material： 医療薬学  (Japanese Journal of Pharmaceutical Health Care and Sciences)
Volume： 38  Issue： 3  Page： 191-195  Publication year： Mar. 10, 2012 
JST Material Number： Y0888A  ISSN： 1346-342X  CODEN： IYRAA3  Document type： Article
Article type： 短報  Country of issue： Japan (JPN)  Language： JAPANESE (JA)

Thesaurus term： *high performance liquid chromatography ,...
Semi thesaurus term： ODS column

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JST classification (2)： Clinical biopharmacy  (GY01022L) ,  Clinical application of antitumor(=antineoplastic)drugs  (GW16020L)

Substance index (2)： Mitotane ,  Acetic acid ethyl

Reference (11)：

• 1)Haak HR, Hermans J, Velde CJ, Lentjes EG, Goslings BM, Fleuren GJ, Krans HM, Optimal treatment of adrenocortical carcinoma with mitotane: results in a consecutive series of 96 patients, Br J Cancer, 1994, 69, 947-951.
• 2)Slooten H, Moolenaar AJ, Seters AP, Smeenk D, The treatment of adrenocortical carcinoma with o, p-DDD: prognostic implications of serum level monitoring, Eur J Clin Oncol, 1984, 20, 47-53.
• 3)Baudin E, Pellegriti G, Bonnay M, Penfornis A, Laplanche A, Vassal G, Schlumberger M, Impact of monitoring plasma 1,1-dichlorodiphenildichloroethane (o, p’DDD) levels on the treatment of patients with adrenocortical carcinoma, Cancer, 2001, 92, 1385-1392.
• 4)Wangberg B, Khorram-Manesh A, Jansson S, Nilsson B, Nilsson O, Jakobsson CE, Lindstedt S, Oden A, Ahlman H, The long-term survival in adrenocortical carcinoma with active surgical management and use of monitored mitotane, Endocr Relat Cancer, 2010, 17, 265-272.
• 5)Terzolo M, Pia A, Berruti A, Osella G, Ali A, Carbone V, Testa E, Dogliotti L, Angeli A, Low-dose monitored mitotane treatment achieves the therapeutic range with manageable side effects in patients with adrenocortical cancer, J Clin Endocrinol Metab, 2000, 85, 2234-2238.

Terms in the title (5)： HPLC ,  ミトタン ,  血中濃度 ,  測定法 ,  開発