Art

J-GLOBAL ID：201202268399911427   Reference number：12A1673560

Serine is a natural ligand and allosteric activator of pyruvate kinase M2

セリンはピルビン酸キナーゼM2の天然のリガンドで,アロステリック活性化因子である

Author (14)： CHANETON Barbara (Cancer Res. UK, Glasgow, GBR) ,  ZHENG Liang (Cancer Res. UK, Glasgow, GBR) ,  MADDOCKS Oliver D. K. (Cancer Res. UK, Glasgow, GBR) ,  VOUSDEN Karen H. (Cancer Res. UK, Glasgow, GBR) ,  FREZZA Christian (Cancer Res. UK, Glasgow, GBR) ,  GOTTLIEB Eyal (Cancer Res. UK, Glasgow, GBR) ,  HILLMANN Petra (Astex Pharmaceuticals, Cambridge, GBR) ,  MARTIN Agnes C. L. (Astex Pharmaceuticals, Cambridge, GBR) ,  COYLE Joseph E. (Astex Pharmaceuticals, Cambridge, GBR) ,  HOLDING Finn P. (Astex Pharmaceuticals, Cambridge, GBR) ,  O'REILLY Marc (Astex Pharmaceuticals, Cambridge, GBR) ,  CHOKKATHUKALAM Achuthanunni (Univ. Glasgow, Glasgow, GBR) ,  JANKEVICS Andris (Univ. Glasgow, Glasgow, GBR) ,  JANKEVICS Andris (Univ. Groningen, Groningen, NLD)
Material： Nature (London)  (Nature (Lond))
Volume： 491  Issue： 7424  Page： 458-462  Publication year： Nov. 15, 2012 
JST Material Number： D0193B  ISSN： 0028-0836  Document type： Article
Article type： 原著論文  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Thesaurus term： *pyruvate kinase ,  allosteric effect ,  *tumor cell ,  human(primates) ,  enzyme activity ,  glycolytic pathway ,  mitochondria ,  cell proliferation ,  enzyme activation ,  biosynthesis ,  amino acid ,  aliphatic amine ,  aliphatic alcohol ,  aliphatic carboxylic acid ,  aminoalcohol ,  hydroxy acid
Semi thesaurus term： *PKM2 ,  amino acid biosynthesis

JST classification (2)： Enzyme physiology  (EJ02020P) ,  Chemistry,biochemistry and pathology of tumors(=neoplasms)  (GE02030N)

Substance index (1)： Serine

Terms in the title (3)： セリン ,  ピルビン酸キナーゼM2 ,  リガンド